The Emergency Medical Team Operating System — a vision for field hospital data management in following the concepts of predictive, preventive, and personalized medicine
In conclusion, to really achieve PPPM-related efforts more investment will need to be put into research and development of electronic patient records as the foundation as well as into the clinical processes along all pathways o f stakeholders in disaster medicine. (Source: EPMA Journal)
Source: EPMA Journal - April 22, 2024 Category: International Medicine & Public Health Source Type: research
Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care —clinically relevant 3PM innovation
AbstractDespite their subordination in humans, to a great extent, mitochondria maintain their independent status but tightly cooperate with the “host” on protecting the joint life quality and minimizing health risks. Under oxidative stress conditions, healthy mitochondria promptly increase mitophagy level to remove damaged “fellows” rejuvenating the mitochondrial population and sending fragments of mtDNA as SOS signals to all system s in the human body. As long as metabolic pathways are under systemic control and well-concerted together, adaptive mechanisms become triggered increasing systemic protection, activatin...
Source: EPMA Journal - April 18, 2024 Category: International Medicine & Public Health Source Type: research
Mediterranean diet in the targeted prevention and personalized treatment of chronic diseases: evidence, potential mechanisms, and prospects
AbstractThe prevalence of chronic diseases is currently a major public health issue worldwide and is exploding with the population growth and aging. Dietary patterns are well known to play a important role in our overall health and well-being, and therefore, poor diet and malnutrition are among the most critical risk factors for chronic disease. Thus, dietary recommendation and nutritional supplementation have significant clinical implications for the targeted treatment of some of these diseases. Multiple dietary patterns have been proposed to prevent chronic disease incidence, like Dietary Approaches to Stop Hypertension ...
Source: EPMA Journal - April 16, 2024 Category: International Medicine & Public Health Source Type: research
Energy metabolism as the hub of advanced non-small cell lung cancer management: a comprehensive view in the framework of predictive, preventive, and personalized medicine
This article provides a detailed overview towards mechanisms and biological pathways involving metabolic reprogramming (MR) with respect to inhibiting the synthesis of biomolecules and blocking common NSCLC metabolic pathways as anti-NSCLC t herapeutic strategies. For instance, mitophagy recycles macromolecules to yield mitochondrial substrates for energy homeostasis and nucleotide synthesis. Histone modification and DNA methylation can predict the onset of diseases, and plasma C7 analysis is an efficient medical service potentially res ulting in an optimized healthcare economy in corresponding areas. The MEMP scoring prov...
Source: EPMA Journal - April 8, 2024 Category: International Medicine & Public Health Source Type: research
Clinically relevant stratification of lung squamous carcinoma patients based on ubiquitinated proteasome genes for 3P medical approach
ConclusionsUbiquitinated proteasome genes were effective in developing a prognostic model for LUSC patients. The study emphasized the critical role of proteasomes in LUSC processes, such as drug sensitivity, immune microenvironment, and mutation status. These data will contribute to the clinically relevant stratification of LUSC patients for personalized 3P medical approach. Further, we also recommend the application of the ubiquitinated proteasome system in multi-level diagnostics including multi-omics, liquid biopsy, prediction and targeted prevention of chronic inflammation and metastatic disease, and mitochondrial heal...
Source: EPMA Journal - March 4, 2024 Category: International Medicine & Public Health Source Type: research
The paradigm change from reactive medical services to 3PM in ischemic stroke: a holistic approach utilising tear fluid multi-omics, mitochondria as a vital biosensor and AI-based multi-professional data interpretation
AbstractWorldwide stroke is the second leading cause of death and the third leading cause of death and disability combined. The estimated global economic burden by stroke is over US$891 billion per year. Within three decades (1990 –2019), the incidence increased by 70%, deaths by 43%, prevalence by 102%, and DALYs by 143%. Of over 100 million people affected by stroke, about 76% are ischemic stroke (IS) patients recorded worldwide. Contextually, ischemic stroke moves into particular focus of multi-professional groups includ ing researchers, healthcare industry, economists, and policy-makers. Risk factors of ischemic stro...
Source: EPMA Journal - February 27, 2024 Category: International Medicine & Public Health Source Type: research
Promoting advanced medical services in the framework of 3PM —a proof-of-concept by the “Centro” Region of Portugal
AbstractMultidisciplinary team from three universities based in the “Centro” Region of Portugal developed diverse approaches as parts of a project dedicated to enhancing and expanding Predictive, Preventive, and Personalized Medicine (3PM) in the Region. In a sense, outcomes acted as a proof-of-concept, in that they demonstrated the feasibility, but also the rel evance of the approaches. The accomplishments comprise defining a new regional strategy for implementing 3PM within the Region, training of human resources in genomic sequencing, and generating good practices handbooks dedicated to diagnostic testing via next-g...
Source: EPMA Journal - February 22, 2024 Category: International Medicine & Public Health Source Type: research
Cancer screening in hospitalized ischemic stroke patients: a multicenter study focused on multiparametric analysis to improve management of occult cancers
ConclusionsThe nomogram enables early occult cancer diagnosis in hospitalized IS patients and helps to accurately identify the cause of IS, while the promotion of IS stratification makes personalized treatment feasible. The online nomogram based on routine clinical examination indicators of IS patients offered a cost-effective platform for secondary care in the framework of PPPM. (Source: EPMA Journal)
Source: EPMA Journal - February 19, 2024 Category: International Medicine & Public Health Source Type: research
Frailty mediating the causality between leucocyte telomere length and mortality: a cohort study of 440,551 UK Biobank participants
ConclusionsOur results indicate that frailty mediates the effect of LTL on all-cause and CVD-specific mortality. There findings might be valuable to predict, prevent, and reduce mortality through primary prevention and healthcare in context of PPPM. (Source: EPMA Journal)
Source: EPMA Journal - February 15, 2024 Category: International Medicine & Public Health Source Type: research
Automated detection of nine infantile fundus diseases and conditions in retinal images using a deep learning system
ConclusionsIRIDS identifies nine infantile fundus diseases and conditions accurately. It may aid non-ophthalmologist personnel in underserved areas in infantile fundus disease screening. Thus, preventing severe complications. The IRIDS serves as an example of artificial intelligence integration into ophthalmology to achieve better outcomes in predictive, preventive, and personalized medicine (PPPM / 3PM) in the treatment of infantile fundus diseases. (Source: EPMA Journal)
Source: EPMA Journal - February 15, 2024 Category: International Medicine & Public Health Source Type: research
Predictive, preventive and personalised approach as a conceptual and technological innovation in primary and secondary care of inflammatory bowel disease benefiting affected individuals and populations
This article analyses current achievements and provides the roadmap for future developments in the area in the context of 3P medicine benefiting society at large. (Source: EPMA Journal)
Source: EPMA Journal - February 9, 2024 Category: International Medicine & Public Health Source Type: research
The mediating effect of perceived stress on the relationship between big five personality traits and suboptimal health status in Chinese population: a nationwide survey in the framework of predictive, preventive, and personalized medicine
ConclusionThis study revealed a high prevalence of SHS in Chinese residents. Personality traits significantly influenced SHS rates, which perceived stress tended to mediate. From a PPPM perspective, early screening and targeted intervention for people with neuroticism (as well as stress alleviation) might contribute to health enhancement and chronic disease prevention. (Source: EPMA Journal)
Source: EPMA Journal - December 11, 2023 Category: International Medicine & Public Health Source Type: research
Nitroproteomics is instrumental for stratification and targeted treatments of astrocytoma patients: expert recommendations for advanced 3PM approach with improved individual outcomes
AbstractProtein tyrosine nitration is a selectively and reversible important post-translational modification, which is closely related to oxidative stress. Astrocytoma is the most common neuroepithelial tumor with heterogeneity and complexity. In the past, the diagnosis of astrocytoma was based on the histological and clinical features, and the treatment methods were nothing more than surgery-assisted radiotherapy and chemotherapy. Obviously, traditional methods short falls an effective treatment for astrocytoma. In late 2021, the World Health Organization (WHO) adopted molecular biomarkers in the comprehensive diagnosis o...
Source: EPMA Journal - December 6, 2023 Category: International Medicine & Public Health Source Type: research
Impacts of a multipurpose outpatient hospital pharmacy in the framework of 3P medicine
Conclusions and expert recommendationsPredictive approachThe presence of pharmacists in the multi-pathology day hospital has a predictive approach. A change is made in the workflow that allows to generate a speed of intervention by acting before prescribing, dispensing and administering the treatment to the patient.Targeted preventionThe presence of pharmacists in the multipurpose day hospital unit and their collaboration with other professionals and the patient bring about a selective prevention that decreases the possibility of medication errors occurring.Personalisation of medical servicesWith the individualised dispens...
Source: EPMA Journal - December 4, 2023 Category: International Medicine & Public Health Source Type: research
Diabetes, glycemic control and arterial stiffness: a real-world cohort study in the context of predictive, preventive, and personalized medicine
ConclusionOur study quantified that diabetes status is closely associated with an increased risk of arterial stiffness and supported that adherence to good glycemic control could attenuate the adverse effect of diabetes on arterial stiffness. Therefore, glucose monitoring and control is a cost-effective strategy for the predictive diagnostics, targeted prevention, patient stratification, and personalization of medical services in early vascular damages and arterial stiffness. (Source: EPMA Journal)
Source: EPMA Journal - November 24, 2023 Category: International Medicine & Public Health Source Type: research
