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Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed. The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Stem cells as an ideal carrier for gene therapy: A new approach to the treatment of hepatitis C virus
CONCLUSION: Gene therapy, either directly and in vivo or indirectly and in vitro, requires carriers (vectors) to transfer the gene. These carriers are divided into two groups, viral and non-viral. In indirect gene therapy, living cells are isolated from a person's body and genetically modified. Stem cells have the properties to transfer the desired genes to the patient's body, including the ability to proliferate for a long time and differentiate into the tissue cells in which they are located.PMID:36150664 | DOI:10.1016/j.trim.2022.101721
Source: Transplant Immunology - September 23, 2022 Category: Transplant Surgery Authors: Alireza Rafati Hadi Esmaeili Gouvarchin Ghaleh Afsaneh Azarabadi Mahmood Reza Masoudi Elmira Afrasiab Akbar Ghorbani Alvanegh Source Type: research

Immunogenicity against hepatitis C virus with mesenchymal stem cells of inbreed BALB/c mice sub cloned with HCVcp protein gene
CONCLUSION: The results of the present study showed that the use of genetically engineered mesenchymal stem cells while maintaining the immunomodulatory properties of these cells can stimulate specific immune system responses against hepatitis C central protein.PMID:35764239 | DOI:10.1016/j.trim.2022.101651
Source: Transplant Immunology - June 28, 2022 Category: Transplant Surgery Authors: Mahmood Reza Masoudi Alireza Rafati Source Type: research

Barriers Against Hepatitis B Vaccination in High-Risk Adults: A Cross-Sectional Study
CONCLUSION: In high-risk adults, the barriers against hepatitis B virus vaccination should be handled by a comprehensive action plan to achieve the WHO 2030 hepatitis elimination target.PMID:35678801 | DOI:10.5152/tjg.2022.21257
Source: The Turkish Journal of Gastroenterology - June 9, 2022 Category: Gastroenterology Authors: Abdullah Tar ık Aslan Ba şak Şaşmazer Yasin Ayar Zeynep Cansu Duran Murat Akova Source Type: research

Lower frequency of T stem cell memory (TSCM) cells in hepatitis B vaccine nonresponders
Immunol Res. 2022 Apr 20. doi: 10.1007/s12026-022-09278-9. Online ahead of print.ABSTRACTDespite the availability of an effective vaccine and antiviral treatments, hepatitis B is still a global public health problem. Hepatitis B vaccination can prevent the disease. Vaccination induces long-lasting protective immune memory, and the identification of memory cell subsets can indicate the effectiveness of vaccines. Here, we compared the frequency of CD4+ memory T cell subsets between responders and nonresponders to HB vaccination. Besides, the frequency of IFN-γ+ memory T cells was compared between studied groups. Study parti...
Source: Cell Research - April 21, 2022 Category: Cytology Authors: Mahsa Eshkevar Vakili Zahra Faghih Jamal Sarvari Mehrnoosh Doroudchi Seyed Nezamedin Hosseini Dieter Kabelitz Kurosh Kalantar Source Type: research

Hepatitis B virus infection modeling using multi-cellular organoids derived from human induced pluripotent stem cells
World J Gastroenterol. 2021 Aug 7;27(29):4784-4801. doi: 10.3748/wjg.v27.i29.4784.ABSTRACTChronic infection with hepatitis B virus (HBV) remains a global health concern despite the availability of vaccines. To date, the development of effective treatments has been severely hampered by the lack of reliable, reproducible, and scalable in vitro modeling systems that precisely recapitulate the virus life cycle and represent virus-host interactions. With the progressive understanding of liver organogenesis mechanisms, the development of human induced pluripotent stem cell (iPSC)-derived hepatic sources and stromal cellular comp...
Source: World Journal of Gastroenterology : WJG - August 27, 2021 Category: Gastroenterology Authors: Di Cao Jian-Yun Ge Yun Wang Tatsuya Oda Yun-Wen Zheng Source Type: research

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