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Total 57 results found since Jan 2013.

The association between rLiHyp1 protein plus adjuvant and amphotericin B is an effective immunotherapy against visceral leishmaniasis in mice
In this study, we evaluated an immunotherapy protocol in a murine model by combining recombinant (r)LiHyp1 (a hypothetical amastigote-specific Leishmania protein protective against Leishmania infantum infection), with monophosphoryl-lipid A (MPLA) as adjuvant and amphotericin B (AmpB) as reference antileishmanial drug. We used this protocol to treat L. infantum infected-BALB/c mice, and parasitological, immunological and toxicological evaluations were performed at 1 and 30 days after treatment. Results showed that mice treated with rLiHyp1/MPLA/AmpB presented the lowest parasite burden in all organs evaluated, when both a ...
Source: Acta Tropica - July 15, 2023 Category: Infectious Diseases Authors: Daniela P Lage V ívian T Martins Danniele L Vale Camila S Freitas Breno L Pimenta Gabriel J L Moreira Fernanda F Ramos Isabela A G Pereira Raquel S Bandeira Marcelo M de Jesus Fernanda Ludolf Grasiele S V Tavares Miguel A Ch ávez-Fumagalli Bruno M Roatt Source Type: research

Fight Aging! Newsletter, June 19th 2023
In conclusion, among Swedish middle-aged subjects, nearly two-thirds showed complete fatty degeneration of thymus on CT. Age-Related Dysfunction of Water Homeostasis https://www.fightaging.org/archives/2023/06/age-related-dysfunction-of-water-homeostasis/ Dehydration can be an issue in older people. As in every complex system in the body, the mechanisms by which hydration is regulated become dysfunctional with advancing age. Researchers here look at the brain region responsible for regulating some of the response to dehydration, cataloging altered gene expression in search of the more important mechani...
Source: Fight Aging! - June 18, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Type-I like metalloproteinase in the venom of the West African saw-scaled carpet viper (Echis ocellatus) has anti-trypanosomal activity against African trypanosomes
Toxicon. 2023 Apr 29:107138. doi: 10.1016/j.toxicon.2023.107138. Online ahead of print.ABSTRACTAfrican trypanosomiasis is an infectious disease caused by hemoparasites of the genus Trypanosoma and remains a major health problem in Africa - killing around 4000 people and animals worth an estimated $5 billion, annually. The absence of a vaccine and satisfactory drug against African trypanosomiasis (AT) necessitates the continued search for new chemotherapy options. Owing to the rich biochemical diversity in snake venom, it has recently become a source of therapeutic peptides that are being explored for the development of nov...
Source: Toxicon - May 1, 2023 Category: Toxicology Authors: Ameh Ilu Mathias A Chia Thais R Cataldi Carlos A Labate Godwin U Ebiloma Peter O Yusuf Mohammed N Shuaibu Emmanuel O Balogun Source Type: research

Type I-like metalloproteinase in the venom of the West African saw-scaled carpet viper (Echis ocellatus) has anti-trypanosomal activity against African trypanosomes
Toxicon. 2023 Apr 29;229:107138. doi: 10.1016/j.toxicon.2023.107138. Online ahead of print.ABSTRACTAfrican trypanosomiasis is an infectious disease caused by hemoparasites of the genus Trypanosoma and remains a major health problem in Africa - killing around 4000 people and animals worth an estimated $5 billion, annually. The absence of a vaccine and satisfactory drug against African trypanosomiasis (AT) necessitates the continued search for new chemotherapy options. Owing to the rich biochemical diversity in snake venom, it has recently become a source of therapeutic peptides that are being explored for the development of...
Source: Toxicon - May 1, 2023 Category: Toxicology Authors: Ameh Ilu Mathias A Chia Thais R Cataldi Carlos A Labate Godwin U Ebiloma Peter O Yusuf Mohammed N Shuaibu Emmanuel O Balogun Source Type: research

Type-I like metalloproteinase in the venom of the West African saw-scaled carpet viper (Echis ocellatus) has anti-trypanosomal activity against African trypanosomes
Toxicon. 2023 Apr 29:107138. doi: 10.1016/j.toxicon.2023.107138. Online ahead of print.ABSTRACTAfrican trypanosomiasis is an infectious disease caused by hemoparasites of the genus Trypanosoma and remains a major health problem in Africa - killing around 4000 people and animals worth an estimated $5 billion, annually. The absence of a vaccine and satisfactory drug against African trypanosomiasis (AT) necessitates the continued search for new chemotherapy options. Owing to the rich biochemical diversity in snake venom, it has recently become a source of therapeutic peptides that are being explored for the development of nov...
Source: Toxicon - May 1, 2023 Category: Toxicology Authors: Ameh Ilu Mathias A Chia Thais R Cataldi Carlos A Labate Godwin U Ebiloma Peter O Yusuf Mohammed N Shuaibu Emmanuel O Balogun Source Type: research

Live-attenuated Japanese encephalitis virus inhibits glioblastoma growth and elicits potent antitumor immunity
In this study, we investigated the safety of a live attenuated Japanese encephalitis vaccine strain (JEV-LAV) virus as an oncolytic virus for intracerebral injection in mice. We infected different GBM cell lines with JEV-LAV to investigate whether it had growth inhibitory effects on GBM cell lines in vitro. We used two models for evaluating the effect of JEV-LAV on GBM growth in mice. We investigated the antitumor immune mechanism of JEV-LAV through flow cytometry and immunohistochemistry. We explored the possibility of combining JEV-LAV with PD-L1 blocking therapy. This work suggested that JEV-LAV had oncolytic activity a...
Source: Cancer Control - April 28, 2023 Category: Cancer & Oncology Authors: Zhongbing Qi Jing Zhao Yuhua Li Bin Zhang Shichuan Hu Yanwei Chen Jinhu Ma Yongheng Shu Yunmeng Wang Ping Cheng Source Type: research

Staphylococcal enterotoxin B as DNA vaccine against breast cancer in a murine model
This study aimed to evaluate the antitumor potency of the SEB DNA vaccine as a new antitumor candidate against breast tumors in vivo. To determine the effect of the SEB construct on inhibiting tumor cell growth in vivo, the synthetic SEB gene, subsequent codon optimization, and embedding the cleavage sites were sub-cloned to an expression vector. Then, SEB construct, SEB, and PBS were injected into the mice. After being vaccinated, 4T1 cancer cells were injected subcutaneously into the right flank of mice. Then, the cytokine levels of IL-4 and IFN-γ were estimated by the ELISA method to evaluate the antitumor activity. Th...
Source: Cancer Control - March 29, 2023 Category: Cancer & Oncology Authors: Raheleh Halabian Abolfazl Jahangiri Hamid Sedighian Elham Behzadi Abbas Ali Imani Fooladi Source Type: research

Structural Insight into Privileged Heterocycles as Anti-Trypanosoma cruzi and brucei Agents
Curr Top Med Chem. 2023 Feb 1. doi: 10.2174/1568026623666230201103843. Online ahead of print.ABSTRACTTrypanosomiasis is caused by parasitic protozoan trypanosomes in vertebrates. T. cruzi and T. brucei are causative agents of Chagas disease (CD) and Human African Trypanosomiasis (HAT), respectively. These life-threatening diseases are a serious threat to public health, with considerable incidence in sub-Saharan African and continental Latin America countries. Although WHO validated mitigated number of HAT cases in Togo (June 2020) and Cote d'Ivoire (December 2020), serious efforts need to be performed for the elimination o...
Source: Current Topics in Medicinal Chemistry - February 1, 2023 Category: Chemistry Authors: Jafar Abbasi Shiran Mina Ghanbari Elaheh Mohammadnejadi Nima Razzaghi-Asl Source Type: research

Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules. MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/ Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, prod...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Immunomodulatory effects of chitosan nanoparticles as vaccine delivery agent against lymphatic filariasis through mucosal immunization
Int J Biol Macromol. 2022 Oct 8:S0141-8130(22)02257-7. doi: 10.1016/j.ijbiomac.2022.10.025. Online ahead of print.ABSTRACTLymphatic filariasis is a parasitic disease caused by nematodes affecting millions of individuals in the tropical region. The complex life cycle of the filarial parasite eludes protective measures such as chemotherapy and vector control. Vaccination through recombinant proteins stands as one of the safe and most effective methods. The filarial antigens Brugia malayi Thioredoxin (TRX) and abundant larval transcript-2 (ALT-2) can induce recognizable levels of protection in murine animal models. Chitosan i...
Source: International Journal of Biological Macromolecules - October 11, 2022 Category: Biochemistry Authors: Malathi Balasubramaniyan Mona Santhanam Vimalraj Vinayagam Kaliraj Perumal Source Type: research

Cancer stem cell antigen nanodisc cocktail elicits anti-tumor immune responses in melanoma
J Control Release. 2022 Oct 4:S0168-3659(22)00664-2. doi: 10.1016/j.jconrel.2022.09.061. Online ahead of print.ABSTRACTOne of the major reasons for poor cancer outcomes is the existence of cancer stem cells (CSCs). CSCs are a small subpopulation of tumor cells that can self-renew, differentiate into the majority of tumor cells, and maintain tumorigenicity. As CSCs are resistant to traditional chemotherapy and radiation, they contribute to metastasis and relapse. Thus, new approaches are needed to target and eliminate CSCs. Here, we sought to target and reduce the frequency of CSCs in melanoma by therapeutic vaccination aga...
Source: Cancer Control - October 7, 2022 Category: Cancer & Oncology Authors: Marisa E Aikins You Qin Hannah Dobson Alireza Hassani Najafabadi Kexing Lyu Yao Xu Ying Xin Anna Schwendeman Max S Wicha Alfred E Chang Qiao Li James J Moon Source Type: research