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Therapy: Immunotherapy
Vaccination: Covid Vaccine
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Total 224 results found since Jan 2013.
Randomized Open-Label Controlled Study of Cancer Vaccine OSE2101 Versus Chemotherapy in HLA-A2-positive Patients with Advanced Non-Small Cell Lung Cancer with Resistance to Immunotherapy: ATALANTE-1
CONCLUSION: In HLA-A2 positive patients with advanced NSCLC and secondary resistance to immunotherapy, OSE2101 increased survival with better safety compared to chemotherapy. Further evaluation in this population is warranted.PMID:37704166 | DOI:10.1016/j.annonc.2023.07.006
Source: Ann Oncol - September 13, 2023 Category: Cancer & Oncology Authors: B Besse E Felip R Garcia Campelo M Cobo C Mascaux A Madroszyk F Cappuzzo W Hilgers G Romano F Denis S Viteri D Debieuvre D Galetta E Baldini None M Razaq G Robinet M Maio A Delmonte B Roch P Masson W Schuette A Zer J Remon D Costantini B Vasseur R Dziadzi Source Type: research
Stimuli-Responsive Hydrogel Microcapsules Harnessing the COVID-19 Immune Response for Cancer Therapeutics
We present the development of stimuli-responsive microcapsules, loaded with a viral immunogenetic agent, harnessing the immune response against the Coronavirus Disease 2019, COVID-19, to selectively attack liver cancer cells (hepatoma) or recognize breast cancer or hepatoma, by expression of green fluorescence protein, GFP. The pH-responsive microcapsules, modified with DNA-tetrahedra nanostructures, increased hepatoma permeation by 50%. Incorporation of a GFP-encoding lentivirus vector inside the tumor-targeting pH-stimulated miRNA-triggered and Alpha-fetoprotein-dictated microcapsules enables the demonstration of neoplas...
Source: Angewandte Chemie - September 7, 2023 Category: Chemistry Authors: Amit Fischer Avner Ehrlich Yevgeni Plotkin Yu Ouyang Klil Asulin Ioannidis Konstantinos Chunhai Fan Yaakov Nahmias Itamar Willner Source Type: research
The Important Role of Interleukin-2 in COVID-19
J Immunol Res. 2023 Aug 22;2023:7097329. doi: 10.1155/2023/7097329. eCollection 2023.ABSTRACTThere is controversial literature about the effects of the interleukin-2 (IL-2) cytokine family in COVID-19 pathogenesis and immunity. So we aimed to identify the potential in the role of the IL-2 family in COVID-19. A narrative review search was done through online databases, including PubMed, Scopus, and Web of Science. The search deadline was up to December 2022. We applied no time limits for the searching strategy. After retrieving articles from the databases, the authors summarized the data into two data extraction tables. The...
Source: Journal of Immunology Research - August 31, 2023 Category: Allergy & Immunology Authors: Leila Ghanbari Naeini Laleh Abbasi Farzaneh Karimi Pajman Kokabian Fahimeh Abdi Abyaneh Delaram Naderi Source Type: research
The kynurenine pathway of tryptophan metabolism: a neglected therapeutic target of COVID-19 pathophysiology and immunotherapy
Biosci Rep. 2023 Jul 24:BSR20230595. doi: 10.1042/BSR20230595. Online ahead of print.ABSTRACTSARS-CoV-2 (COVID-19) exerts profound changes in the kynurenine (Kyn) pathway (KP) of tryptophan (Trp) metabolism that may underpin its pathophysiology. The KP is the main source of the vital cellular effector NAD+ and intermediate metabolites that modulate immune and neuronal functions. Trp metabolism is the top pathway influenced by COVID-19. Sixteen studies established virus-induced activation of the KP mediated mainly by induction of indoleamine 2,3-dioxygenase (IDO1) in most affected tissues and of IDO2 in lung by the increase...
Source: Bioscience Reports - July 24, 2023 Category: Biomedical Science Authors: Abdulla Abu-Bakr Badawy Source Type: research
mRNA: A promising platform for cancer immunotherapy
Adv Drug Deliv Rev. 2023 Jul 4:114993. doi: 10.1016/j.addr.2023.114993. Online ahead of print.ABSTRACTMessenger RNA (mRNA) is now in the limelight as a powerful tool for treating various human diseases, especially malignant tumors, thanks to the remarkable clinical outcomes of mRNA vaccines using lipid nanoparticle technology during the COVID-19 pandemic. Recent promising preclinical and clinical results that epitomize the advancement in mRNA and nanoformulation-based delivery technologies have highlighted the tremendous potential of mRNA in cancer immunotherapy. mRNAs can be harnessed for cancer immunotherapy in forms of ...
Source: Advanced Drug Delivery Reviews - July 6, 2023 Category: Drugs & Pharmacology Authors: Byoungjae Kong Yelee Kim Eun Hye Kim Jung Soo Suk Yoosoo Yang Source Type: research
Mushroom β-glucans: application and innovation for food industry and immunotherapy
Appl Microbiol Biotechnol. 2023 Jul 6. doi: 10.1007/s00253-023-12656-4. Online ahead of print.ABSTRACTAmong the most important sources of β-glucans are edible and medicinal mushrooms. These molecules are components of the cellular wall of basidiomycete fungi (mushrooms) and can be extracted even from the basidiocarp as the mycelium and its cultivation extracts or biomasses. Mushroom β-glucans are recognized by their potential effects as immunostimulants and immunosuppressants. They are highlighted as anticholesterolemic, anti-inflammatory, adjuvant in diabetes mellitus, mycotherapy for cancer treatment, as well as adjuva...
Source: Applied Microbiology and Biotechnology - July 6, 2023 Category: Microbiology Authors: Thayn ã Gonçalves Timm Tania Maria Costa Michele Debiasi Alberton Cristiane Vieira Helm Lorena Benathar Ballod Tavares Source Type: research
mRNA: A promising platform for cancer immunotherapy
Adv Drug Deliv Rev. 2023 Jul 4:114993. doi: 10.1016/j.addr.2023.114993. Online ahead of print.ABSTRACTMessenger RNA (mRNA) is now in the limelight as a powerful tool for treating various human diseases, especially malignant tumors, thanks to the remarkable clinical outcomes of mRNA vaccines using lipid nanoparticle technology during the COVID-19 pandemic. Recent promising preclinical and clinical results that epitomize the advancement in mRNA and nanoformulation-based delivery technologies have highlighted the tremendous potential of mRNA in cancer immunotherapy. mRNAs can be harnessed for cancer immunotherapy in forms of ...
Source: Advanced Drug Delivery Reviews - July 6, 2023 Category: Drugs & Pharmacology Authors: Byoungjae Kong Yelee Kim Eun Hye Kim Jung Soo Suk Yoosoo Yang Source Type: research
Biomaterial-based delivery platforms for transdermal immunotherapy
Biomed Pharmacother. 2023 Jun 27;165:115048. doi: 10.1016/j.biopha.2023.115048. Online ahead of print.ABSTRACTNowadays, immunotherapy is one of the most essential treatments for various diseases and a broad spectrum of disorders are assumed to be treated by altering the function of the immune system. For this reason, immunotherapy has attracted a great deal of attention and numerous studies on different approaches for immunotherapies have been investigated, using multiple biomaterials and carriers, from nanoparticles (NPs) to microneedles (MNs). In this review, the immunotherapy strategies, biomaterials, devices, and disea...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 29, 2023 Category: Drugs & Pharmacology Authors: Mohammad Dahri Nima Beheshtizadeh Nasrin Seyedpour Amin Nakhostin-Ansari Faezeh Aghajani Simin Seyedpour Moein Masjedi Fatemeh Farjadian Reza Maleki Khosro Adibkia Source Type: research
Advances in mRNA Therapeutics for Cancer Immunotherapy: From Modification to Delivery
Adv Drug Deliv Rev. 2023 Jun 25:114973. doi: 10.1016/j.addr.2023.114973. Online ahead of print.ABSTRACTRNA vaccines have demonstrated their ability to solve the issues posed by the COVID-19 pandemic. This success has led to the renaissance of research into mRNA and their nanoformulations as potential therapeutic modalities for various diseases. The potential of mRNA as a template for synthesizing proteins and protein fragments for cancer immunotherapy is now being explored. Despite the promise, the use of mRNA in cancer immunotherapy is limited by challenges, such as low stability against extracellular RNases, poor deliver...
Source: Advanced Drug Delivery Reviews - June 27, 2023 Category: Drugs & Pharmacology Authors: Geonhee Han Dahye Noh Hokyung Lee Sangmin Lee Sehoon Kim Hong Yeol Yoon Soo Hyeon Lee Source Type: research
