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Specialty: Microbiology
Vaccination: Influenza Vaccine
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Total 103 results found since Jan 2013.
Broad-spectrum pan-genus and pan-family virus vaccines
Cell Host Microbe. 2023 Jun 14;31(6):902-916. doi: 10.1016/j.chom.2023.05.017.ABSTRACTAlthough the development and clinical application of SARS-CoV-2 vaccines during the COVID-19 pandemic demonstrated unprecedented vaccine success in a short time frame, it also revealed a limitation of current vaccines in their inability to provide broad-spectrum or universal protection against emerging variants. Broad-spectrum vaccines, therefore, remain a dream and challenge for vaccinology. This review will focus on current and future efforts in developing universal vaccines targeting different viruses at the genus and/or family levels,...
Source: Cell Host and Microbe - June 15, 2023 Category: Microbiology Authors: Chee Wah Tan Sophie A Valkenburg Leo L M Poon Lin-Fa Wang Source Type: research
Induction of Homosubtypic and Heterosubtypic Immunity to Influenza Viruses Using a Conserved Internal and External Proteins
Curr Microbiol. 2023 May 16;80(6):212. doi: 10.1007/s00284-023-03331-y.ABSTRACTThe immunogenicity and protective properties of the designed recombinant fusion peptide of 3M2e and truncated nucleoprotein (trNP), originating from Influenza A virus, were investigated in the BALB/c mice model in comparison with the Mix protein (3M2e + trNP). The results were evaluated by antibody response, cytokine production, lymphocyte proliferation assay, and mortality rate after challenge with homologous (H1N1) and heterologous (H3N2) influenza viruses in BALB/c mice. The animals that received the chimer protein with or without adjuvant ha...
Source: Current Microbiology - May 16, 2023 Category: Microbiology Authors: Mahnoosh Maleki Seyed Masoud Hosseini Behrokh Farahmand Maryam Saleh Hadiseh Shokouhi Ali Torabi Fatemeh Fotouhi Source Type: research
Evaluation of the antiviral potential of gemini surfactants against influenza virus H1N1
In this study, the antiviral capacity of some GS compounds with different levels of hydrophobicity was examined. The 50% cytotoxic (CC50) and non-cytotoxic (NCTC) concentrations of the compounds were determined by MTT method. The NCTCs, the same as effective concentrations (EC50s), were tested for the antiviral capacity against IAV in different combination treatments for 1 h incubation on MDCK cells. The HA and MTT assays were used to evaluate the virus titer and cell viabilities, respectively. The hemolytic activity of the compounds was also assessed using an HA inhibition assay. To evaluate the apoptotic effect of GS com...
Source: Archives of Microbiology - April 11, 2023 Category: Microbiology Authors: Mehrnaz Khodsiani Zahra Kianmehr Bogumil Brycki Adrianna Szulc Parvaneh Mehrbod Source Type: research
Pili Subunit PilA Contributes to the Cytoadhesion of < em > Glaesserella Parasuis < /em > to Host Cells and Provides Immunoprotection
In this study, the PilA protein, which is a common virulence factor in other bacteria that mediates adherence to the host, was assessed. The results suggested that the PilA protein of G. parasuis can mediate adhesion to host cells through FN and LN, which provides a new idea for the study of the pathogenicity of G. parasuis. Furthermore, fimbriae usually have high immunogenicity. Immunogenicity and protective capacity results showed that the use of this recombinant PilA antigen might be a promising candidate vaccine antigen with which to prevent G. parasuis infections.PMID:36920203 | DOI:10.1128/aem.02002-22
Source: Applied and Environmental Microbiology - March 15, 2023 Category: Microbiology Authors: Jiahui An Jinshuang Cai Baoge Zhang Yufeng Li Source Type: research
Monoclonal antibody targeting a novel linear epitope on nucleoprotein confers pan-reactivity to influenza A virus
Appl Microbiol Biotechnol. 2023 Feb 23:1-14. doi: 10.1007/s00253-023-12433-3. Online ahead of print.ABSTRACTNucleoprotein (NP) functions crucially in the replicative cycle of influenza A virus (IAV) via forming the ribonucleoprotein complex together with PB2, PB1, and PA proteins. As its high conservation, NP ranks one of the hot targets for design of universal diagnostic reagents and antiviral drugs for IAV. Here, we report an anti-NP murine monoclonal antibody (mAb) 5F10 prepared from traditional lymphocyte hybridoma technique with the immunogen of a clade 2.3.4.4 H5N1 subtype avian influenza virus. The specificity of mA...
Source: Applied Microbiology and Biotechnology - February 23, 2023 Category: Microbiology Authors: Min Gu Jun Jiao Suhan Liu Wanchen Zhao Zhichuang Ge Kairui Cai Lijun Xu Dongchang He Xinyu Zhang Xian Qi Wenming Jiang Pinghu Zhang Xiaoquan Wang Shunlin Hu Xiufan Liu Source Type: research
JMM Profile: Swine influenza A virus: a neglected virus with pandemic potential
J Med Microbiol. 2023 Jan;72(1). doi: 10.1099/jmm.0.001623.ABSTRACTSwine influenza is an acute respiratory disease of swine caused by swine influenza A virus (SwIAV). The ability of SwIAV to spread bidirectionally from animals to humans (zoonotic), and from humans to animals (reverse zoonotic), drives coinfection that can result in gene segment exchange and elevates the risk of generating viruses with pandemic potential. Compared to human-origin influenza A viruses, current data indicate a greater diversity amongst circulating SwIAVs, with three major subtypes (classified by haemagglutinin and neuraminidase) circulating gl...
Source: Journal of Medical Microbiology - February 7, 2023 Category: Microbiology Authors: Benjamin C Mollett Helen E Everett Pauline M van Diemen Alexander M P Byrne Andrew Ramsay Joe James Scott M Reid Rowena D E Hansen Nicola S Lewis Ian H Brown Ashley C Banyard Source Type: research
Evaluation of the World Health Organization Global Invasive Bacterial Vaccine-Preventable Disease (IB-VPD) Surveillance Network's Laboratory External Quality Assessment Programme, 2014-2019
Conclusion. The EQA has been an important tool in maintaining high standards of laboratory testing and building of laboratory capacity in the GISN.PMID:36748422 | DOI:10.1099/jmm.0.001644
Source: Journal of Medical Microbiology - February 7, 2023 Category: Microbiology Authors: David Litt Mary P E Slack Tomoka Nakamura Steve Gray Shila Seaton Elizabeth J Fagan Carmen Sheppard Jason M Mwenda Gloria Rey-Benito Amany Ghoniem Dovile Videbaek Emanuel Tondo Varja Grabovac Fatima Serhan Source Type: research
