Phase 2 Nipocalimab Data Establish Proof of Mechanism in Adults Living with Moderate to Severe Rheumatoid Arthritis, Supporting its Progression into a Combination Study
SPRING HOUSE, Pa., Nov. 7, 2023 /PRNewswire/ -- The Janssen Pharmaceutical Companies of Johnson& Johnson today announced data from the Phase 2a IRIS-RA clinical study for the treatment of adults living with moderate to severe active... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - November 7, 2023 Category: Pharmaceuticals Source Type: clinical trials

A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics of Subcutaneous AZD6912 in Healthy Participants
Conditions: Rheumatoid Arthritis Interventions: Drug: AZD6912; Drug: Placebo Sponsors: AstraZeneca Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 3, 2023 Category: Research Source Type: clinical trials

A Prospective, Pre-market, Multi-center Study of Insignia Hip Stem in THA to Determine Implant Survivorship and PROMS.
Conditions: Arthritis (E.G., Degenerative Joint Disease (DJD), Osteoarthritis, and Rheumatoid Arthritis (RA)) Interventions: Device: Hip stem prosthesis Sponsors: Stryker Australia Pty Ltd. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 31, 2023 Category: Research Source Type: clinical trials

Clinical Study Evaluating the Effect of Carvedilol in Patients With Active Rheumatoid Arthritis
Conditions: Rheumatoid Arthritis Interventions: Drug: Carvedilol Sponsors: Tanta University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 31, 2023 Category: Research Source Type: clinical trials

Effectiveness and feasibility of a mobile health self-management intervention in rheumatoid arthritis: study protocol for a pragmatic multicentre randomised controlled trial (AEGORA)
DiscussionThe AEGORA trial aims to study the effectiveness of mHealth-based, multicomponent self-management support to improve self-efficacy in the context of RA, while providing potentially valuable insights into temporal disease activity dynamics and the feasibility and possible negative effects of remote symptom monitoring in this population.Trial registrationClinicaltrials.gov NCT05888181. Retrospectively registered on March 23, 2023. Study inclusion started on March 3, 2023. (Source: Trials)
Source: Trials - October 28, 2023 Category: Research Source Type: clinical trials

A Study of Single and Multiple Oral Doses of TollB-001
Conditions: Rheumatoid Arthritis Interventions: Drug: TollB-001 tablets; Drug: TollB-001 placebo Sponsors: Toll Biotech Co. Ltd. (Beijing) Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 27, 2023 Category: Research Source Type: clinical trials

A Study of LNK01001 Capsule in Moderately to Severely Active Rheumatoid Arthritis
Conditions: Rheumatoid Arthritis Interventions: Drug: LNK01001 Dose A; Drug: LNK01001 Dose B; Drug: placebo Sponsors: Lynk Pharmaceuticals Co., Ltd Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 25, 2023 Category: Research Source Type: clinical trials

FDA Clears Application to Initiate Phase 1 Clinical Study of oral Immunotherapy for the Treatment of Rheumatoid Arthritis
ROCKVILLE, Md., Oct. 19, 2023. - Rise Therapeutics, a biotechnology company engaged in developing novel oral immunotherapeutics, today announced that the U.S. Food and Drug Administration (FDA) has accepted its investigational new drug (IND)... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - October 20, 2023 Category: Pharmaceuticals Source Type: clinical trials

Prevalence of Subclinical Vertebral Fractures in Rheumatoid Arthritis and Ankylosing Spondylitis
Conditions: Vertebral Fracture Interventions: Device: DEXA scan,X_ray Sponsors: Assiut University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 20, 2023 Category: Research Source Type: clinical trials

A Phase 1b Study of Imvotamab in Moderate to Severe Rheumatoid Arthritis
Conditions: Rheumatoid Arthritis; Arthritis, Rheumatoid; Arthritis Interventions: Drug: Imvotamab; Drug: Placebo Sponsors: IGM Biosciences, Inc. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 17, 2023 Category: Research Source Type: clinical trials

Dynamic Treatment Regiments for Glucocorticoid Tapering
Conditions: Rheumatoid Arthritis Interventions: Drug: Oral prednisone Taper Sponsors: VA Office of Research and Development Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 9, 2023 Category: Research Source Type: clinical trials

The Living With a Long-Term Condition Study
Conditions: Asthma; Atrial Fibrillation; Cancer; Cerebrovascular Disorders; Stroke; CKD; Copd; Fibromyalgia; Pain; Heart Diseases; Heart Disease Chronic; Dementia; Diabetes; Epilepsy; Heart Failure; High Blood Pressure; Hypertension; Hiv; AIDS; IBD; IBS; Liver Diseases; Long COVID; Lupus Erythematosus; Multiple Sclerosis; Obesity; Osteoarthritis; Arthritis; Rheumatoid Arthritis; Osteoporosis; Parkinson Disease; Sickle Cell Disease; Hepatitis; Endometriosis; PCOS; Neurological Disorder; POTS - Postural Orthostatic Tachycardia Syndrome; MND (Motor Neurone DIsease); Cystic Fibrosis; Migraine; Spondylitis; Celiac Disease; Hidr...
Source: ClinicalTrials.gov - October 9, 2023 Category: Research Source Type: clinical trials

A Study to Evaluate SAR441566 Efficacy and Safety in Adults With Rheumatoid Arthritis
Conditions: Rheumatoid Arthritis Interventions: Drug: SAR441566; Drug: Placebo Sponsors: Sanofi Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 9, 2023 Category: Research Source Type: clinical trials

MITIG.RA: study protocol of a tailored psychological intervention for managing fatigue in rheumatoid arthritis randomized controlled trial
This study prima rily aims to examine the efficacy of the Compassion and Mindfulness Intervention for RA (MITIG.RA), a novel intervention combining different components of CCBT, compared to treatment-as-usual (TAU) in the management of RA-associated fatigue. Secondary aims involve exploring whether MITIG.RA produces changes in the perceived impact of disease, satisfaction with disease status, levels of depression, and emotion-regulation skills.MethodsThis is a single center, two-arm parallel randomized controlled trial. Patients will be screened for eligibility and willingness to participate and will be assessed and random...
Source: Trials - October 6, 2023 Category: Research Source Type: clinical trials

Distress in Rheumatoid Arthritis Patients
Conditions: Arthritis, Rheumatoid; Distress, Emotional Interventions: Other: Distress evaluation Sponsors: Bozyaka Training and Research Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 5, 2023 Category: Research Source Type: clinical trials