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Procedure: Heart Transplant
Therapy: Stem Cell Therapy

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Total 492 results found since Jan 2013.

Combined Treatment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates
CONCLUSIONS: These results demonstrate the synergistic effect of combining iPSC-derived ECs and CMs for therapy in the postmyocardial infarction heart, enabling a promising strategy toward clinical translation.PMID:37732466 | DOI:10.1161/CIRCULATIONAHA.122.061736
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Yu-Che Cheng Marvin L Hsieh Chen-Ju Lin Cindy M C Chang Ching-Ying Huang Riley Puntney Amy Wu Moy Chien-Yu Ting Darien Zhing Herr Chan Martin W Nicholson Po-Ju Lin Hung-Chih Chen Gina C Kim Jianhua Zhang Jennifer Coonen Puja Basu Heather A Simmons Yen-Wen Source Type: research

Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Expanding the clinical and immunological phenotypes of PAX1-deficient SCID and CID patients
We described six new patients who demonstrated variable clinical penetrance. Reduced transcriptional activity of pathogenic variants confirmed partial or complete PAX1 deficiency. Thymic aplasia and hypoplasia were associated with impaired T-cell immunity. Corrective treatment was required in 4/6 patients. Hematopoietic stem cell transplantation resulted in poor immune reconstitution with absent naïve T cells, contrasting with the superior recovery of T-cell immunity after thymus transplantation. Normal ex vivo differentiation of PAX1-deficient CD34+ cells into mature T-cell demonstrated the absence of a hematopoietic cel...
Source: Clinical Immunology - September 9, 2023 Category: Allergy & Immunology Authors: Nalan Yakici Alexandra Y Kreins Mehmet Cihangir Catak Royala Babayeva Baran Erman Heather Kenney Hatice Eke Gungor Pablo A Cea Tomoki Kawai Marita Bosticardo Ottavia Maria Delmonte Stuart Adams Yu-Tong Fan Francesca Pala Ayberk Turkyilmaz Evey Howley Aust Source Type: research

Mature human  induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin
CONCLUSIONS: Long-term cultured mature hiPSC-CMs promoted engraftment, maturation and angiogenesis post-transplantation in infarcted rat hearts. CRYAB, which was highly expressed in D56-CMs, was identified as an angiogenic factor from mature hiPSC-CMs. This study revealed the benefits of long-term culture, which may enhance the therapeutic potential of hiPSC-CMs.PMID:37679796 | DOI:10.1186/s13287-023-03468-4
Source: Cell Research - September 7, 2023 Category: Cytology Authors: Yuki Tanaka Shin Kadota Jian Zhao Hideki Kobayashi Satomi Okano Masaki Izumi Yusuke Honda Hajime Ichimura Naoko Shiba Takeshi Uemura Yuko Wada Shinichiro Chuma Tsutomu Nakada Shugo Tohyama Keiichi Fukuda Mitsuhiko Yamada Tatsuichiro Seto Koichiro Kuwahara Source Type: research

Human myofibroblasts increase the arrhythmogenic potential of human induced pluripotent stem cell-derived cardiomyocytes
Cell Mol Life Sci. 2023 Sep 5;80(9):276. doi: 10.1007/s00018-023-04924-3.ABSTRACTHuman induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have the potential to remuscularize infarcted hearts but their arrhythmogenicity remains an obstacle to safe transplantation. Myofibroblasts are the predominant cell-type in the infarcted myocardium but their impact on transplanted hiPSC-CMs remains poorly defined. Here, we investigate the effect of myofibroblasts on hiPSC-CMs electrophysiology and Ca2+ handling using optical mapping of advanced human cell coculture systems mimicking cell-cell interaction modalities. Human ...
Source: Cellular and Molecular Life Sciences : CMLS - September 5, 2023 Category: Cytology Authors: Robert D Johnson Ming Lei John H McVey Patrizia Camelliti Source Type: research

Recent advances in regulating the proliferation or maturation of human-induced pluripotent stem cell-derived cardiomyocytes
Stem Cell Res Ther. 2023 Aug 30;14(1):228. doi: 10.1186/s13287-023-03470-w.ABSTRACTIn the last decade, human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM)-based cell therapy has drawn broad attention as a potential therapy for treating injured hearts. However, mass production of hiPSC-CMs remains challenging, limiting their translational potential in regenerative medicine. Therefore, multiple strategies including cell cycle regulators, small molecules, co-culture systems, and epigenetic modifiers have been used to improve the proliferation of hiPSC-CMs. On the other hand, the immaturity of these proliferat...
Source: Cell Research - August 30, 2023 Category: Cytology Authors: Hao Yang Yuan Yang Fedir N Kiskin Mengcheng Shen Joe Z Zhang Source Type: research

Fight Aging! Newsletter, August 28th 2023
In conclusion, we identified 20 genes with significant evolutionary signals unique to long-lived species, which provided new insight into the lifespan extension of mammals and might bring new strategies to extend human lifespan. « Back to Top Trials of Xenotransplantation of Pig Organs into Humans Continue https://www.fightaging.org/archives/2023/08/trials-of-xenotransplantation-of-pig-organs-into-humans-continue/ Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants in...
Source: Fight Aging! - August 27, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Research progress on cardiac tissue construction of mesenchymal stem cells for myocardial infarction
This study shows that MSCs have wide clinical applications in the treatment of AMI, suggesting improved myocardial tissue creation. A broader clinical application prospect will be explored and developed to improve the survival rate of MSC transplants and myocardial vascularization.PMID:37612870 | DOI:10.2174/1574888X18666230823091017
Source: Current Stem Cell Research and Therapy - August 24, 2023 Category: Stem Cells Authors: Guo-Dong Yang Da-Shi Ma Chun-Ye Ma Yang Bai Source Type: research