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Total 86 results found since Jan 2013.
Comparative effectiveness of mRNA-1273 and BNT162b2 COVID-19 vaccines in immunocompromised individuals: a systematic review and meta-analysis using the GRADE framework
ConclusionThis GRADE meta-analysis based on a large number of consistent observational studies showed that the mRNA-1273 COVID-19 vaccine is associated with improved clinical effectiveness in IC populations compared with BNT162b2.
Source: Frontiers in Immunology - September 12, 2023 Category: Allergy & Immunology Source Type: research
Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease
https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/
With the caveat that mouse models of Alzheimer's...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Preventive health care in blood cancer survivors: results from the ABC study
CONCLUSIONS: Utilization of preventive care is high among German blood cancer survivors. To ensure widespread delivery and avoid redundancy, communication between oncologists and preventive care providers is essential.PMID:37395845 | DOI:10.1007/s00432-023-04984-9
Source: Clinical Genitourinary Cancer - July 3, 2023 Category: Cancer & Oncology Authors: Julia Baum Hildegard Lax Nils Lehmann Anja Merkel-Jens Dietrich W Beelen Karl-Heinz J öckel Ulrich D ührsen Source Type: research
TWiV 990: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses confronting the evolution and expansion of anti-vaccine activism in the USA in the COVID-19 era, the effectiveness of maternal Influenza vaccination in Peru, characteristics and predictors of persistent symptoms post-COVID-19 in children and young people, parental nonadherence to health policy recommendations for prevention of COVID-19 transmission among children, community-onset bacterial coinfection in children critically ill with SARS-CoV-2 infection, bivalent booster effectiveness against severe COVID-19 outcomes in Finland, viral kinetics of sequential SARS-CoV-2 inf...
Source: This Week in Virology - MP3 Edition - March 11, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Immunity to fungi in the lung
Semin Immunol. 2023 Feb 23;66:101728. doi: 10.1016/j.smim.2023.101728. Online ahead of print.ABSTRACTThe respiratory tree maintains sterilizing immunity against human fungal pathogens. Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal pathogens that form small airborne conidia. In addition, pathogenic yeasts, exemplified by encapsulated Cryptococcus species, and Pneumocystis pose significant fungal threats to the lung. Classically, fungal pneumonia occurs in immune compromised individuals, specifically in patients with HIV/AIDS, in patients with hematologic malignancies, in organ tra...
Source: Seminars in Immunology - February 25, 2023 Category: Allergy & Immunology Authors: Lena J Heung Darin L Wiesner Keyi Wang Amariliz Rivera Tobias M Hohl Source Type: research
Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed.
The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
TWiV 982: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the consistency of COVID-19 trial preprints with published reports and impact for decision making, the negative effect of preexisting immunity on Influenza vaccine responses transcends the impact of vaccine formulation type and vaccination history, highly pathogenic avian influenza A(H5N1) virus infection in farmed minks in Spain, Peru confirms H5N1 avian flu in marine mammals, prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies, bacillu...
Source: This Week in Virology - MP3 Edition - February 11, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Rates of Influenza and Pneumococcal Vaccination and Correlation With Survival in Multiple Myeloma Patients
CONCLUSION: Vaccination is important in MM and should be encouraged. Vaccination status should be recorded in prospective clinical trials as it may affect survival. This trial was registered at www.CLINICALTRIALS: gov as #NCT02761187.PMID:36641358 | DOI:10.1016/j.clml.2022.12.003
Source: Clinical Lymphoma and Myeloma - January 14, 2023 Category: Cancer & Oncology Authors: Michael A Thompson Mario Boccadoro Xavier Leleu Jorge Vela-Ojeda Frits van Rhee Katja C Weisel Robert M Rifkin Saad Z Usmani Roman H ájek Gordon Cook Rafat Abonour Mira Armour Kathryn E Morgan Su-Peng Yeh Caitlin L Costello Jesus G Berdeja Faith E Davies Source Type: research
Investigation on the hesitancy of COVID-19 vaccination among liver transplant recipients: A cross-sectional study in China
CONCLUSION: For liver transplant recipients, COVID-19 vaccine is an important preventive measure. Identifying the factors influencing COVID-19 vaccine hesitancy is therefore critical to developing a promotion plan. Our study shows that more comprehensive vaccine knowledge popularization and relevant medical workers' training can effectively improve the acceptance of COVID-19 vaccine in this population.PMID:36589975 | PMC:PMC9797997 | DOI:10.3389/fpubh.2022.1014942
Source: Pain Physician - January 2, 2023 Category: Anesthesiology Authors: Yixiao Pan Shiming Gong Xinye Zhu Chuqing Xue Yilei Jing Yinghua Sun Yongbing Qian Jianjun Zhang Qiang Xia Source Type: research
Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules.
MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity
https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/
Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, prod...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
