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Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed. The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A 54-Year-Old Man With Migratory Pulmonary Consolidation and Progressive Dyspnea
Chest. 2022 Aug;162(2):e85-e88. doi: 10.1016/j.chest.2022.03.004.ABSTRACTA 54-year-old man with chronic hepatitis B was admitted to the hospital with progressive dyspnea on exertion. He reported experiencing intermittent fever, dyspnea on exertion, and relapsing pleuritic chest pain starting 6 months prior, after his first dose of the ChAdOx1 nCoV-19 vaccine. In the past 2 months, he had been admitted to the hospital twice and diagnosed with recurrent pneumonia. Under antibiotic treatment, his dyspnea and low-grade fever demonstrated waxing and waning behaviors. Migratory pulmonary consolidation, which moved from the left ...
Source: Chest - August 8, 2022 Category: Respiratory Medicine Authors: Juei-Yang Ma Cheng-Hao Chuang Source Type: research

The Virus Hunters Trying to Prevent the Next Pandemic
Nobody saw SARS-CoV-2 coming. In the early days of the pandemic, researchers were scrambling to collect samples from people who had mysteriously developed fevers, coughs, and breathing problems. Pretty soon, they realized that the disease-causing culprit was a new virus humans hadn’t seen before. And the world, lacking a coordinated global response, was unprepared. Some countries acted quickly to develop tests for the novel coronavirus, while others with fewer resources were left behind. With a virus oblivious to national borders, and with travel between countries and continents more common than it had been in previo...
Source: TIME: Health - August 1, 2022 Category: Consumer Health News Authors: Alice Park and Video by Andrew D. Johnson Tags: Uncategorized Disease Frontiers of Medicine 2022 healthscienceclimate Source Type: news

Multi-residue method for the detection of 40 β-lactam-antibiotics in vaccines by LC-MS/MS
Anal Biochem. 2021 Aug 12:114299. doi: 10.1016/j.ab.2021.114299. Online ahead of print.ABSTRACTAntibiotics are widely used to treat bacterial infections during the process of vaccine production and storage resulting in antibiotic residues that can cause serious harm. A simple and sensitive method for residue analysis of 40 β-lactam antibiotics was developed and validated for vaccines including inactivated enterovirus 71 vaccine (Vero cells), recombinant hepatitis B vaccine (Saccharomyces cerevisiae), and live attenuated varicella vaccine using liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-...
Source: Analytical Biochemistry - August 15, 2021 Category: Biochemistry Authors: Qing Yang Ying Liu Zhiqin Jiang Mingzhe Xu Shangchen Yao Changgui Li Guoqing Chen Miao Xu Wanhui Liu Lihui Yin Zhongyu Hu Source Type: research

Quantitative Prediction of the Landscape of T Cell Epitope Immunogenicity in Sequence Space
This study indicates that targeting of epitopes by human adaptive immunity is to some extent directed by defined thermodynamic principles. The proposed framework also has a practical implication in that it may enable to more efficiently prioritize epitope candidates highly prone to T cell recognition in multiple individuals, warranting prospective validation across different cohorts. Introduction T cell epitopes bound to major histocompatibility complex [MHC; also called the human leukocyte antigen (HLA) in humans] molecules activate T cells to initiate subsequent immunological orchestration (1–3). MHC clas...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

Poly-ICLC, a TLR3 Agonist, Induces Transient Innate Immune Responses in Patients With Treated HIV-Infection: A Randomized Double-Blinded Placebo Controlled Trial
Conclusions: These finding suggest that Poly-ICLC could be safely used for inducing transient innate immune responses in treated HIV+ subjects indicating promise as an adjuvant for HIV therapeutic vaccines. Trial Registration: www.ClinicalTrials.gov, identifier: NCT02071095. Introduction Innate immune dysregulation during HIV infection hinders the formation of anti-HIV adaptive immunity (1–6) resulting in rampant viral dissemination and progression to AIDS. Adherence to combination anti-retroviral therapy (cART) regimens controls viremia, restores CD4+T cell counts and reverses immune dysfunction to ...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research

Improving adult immunization equity: Where do the published research literature and existing resources lead?
Abstract Evidence suggests that disparities in adult immunization (AI) rates are growing. Providers need adequate patient resources and information about successful interventions to help them engage in effective practices to reduce AI disparities. The primary purposes of this paper were to review and summarize the evidence base regarding interventions to reduce AI disparities and to scan for relevant resources that could support providers in their AI efforts to specifically target disparities. First, building on a literature review conducted by the U.S. Centers for Disease Control and Prevention, we searched the p...
Source: Vaccine - April 25, 2017 Category: Allergy & Immunology Authors: Prins W, Butcher E, Hall LL, Puckrein G, Rosof B Tags: Vaccine Source Type: research

Ten-point plan to tackle liver disease published
"Doctors call for tougher laws on alcohol abuse to tackle liver disease crisis," The Guardian reports. But this is just one of 10 recommendations for tackling the burden of liver disease published in a special report in The Lancet.The report paints a grim picture of an emerging crisis in liver disease in the UK, saying it is one of the few countries in Europe where liver disease and deaths have actually increased rapidly over the last 30 years. It concludes with 10 recommendations to tackle the burden of liver disease.The media has approached the recommendations from many different angles, with many sources only ...
Source: NHS News Feed - November 27, 2014 Category: Consumer Health News Tags: Food/diet Lifestyle/exercise QA articles Source Type: news

Five Month-Old Baby Dies Just Days After 8 Vaccinations – Parents Are Charged With Her Murder
Conclusion As with so many of these cases, Baby A did not just receive just one vaccine, so it is therefore difficult to pinpoint exactly which vaccine, if any, may have led to her death. However, it is vital that the doctors involved in this case as with all cases, consider the vaccines as a possible contributory factor. Sadly, these parents have been accused and charged with the murder of their daughter without any substantial evidence of foul play. There appears to be no evidence of external head injuries or bruising to the upper body to indicate that Baby A had been shaken. I believe that if this child had been shaken ...
Source: vactruth.com - August 17, 2013 Category: Health Medicine and Bioethics Commentators Authors: Christina England Tags: Christina England Top Stories Adverse Reaction Dr. Viera Schreibner Prevenar shaken baby syndrome Vaccine Adverse Event Reporting System (VAERS) Vaccine Death Source Type: blogs