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Steroid induced secondary immune deficiency
Ann Allergy Asthma Immunol. 2023 Jan 18:S1081-1206(23)00011-X. doi: 10.1016/j.anai.2023.01.010. Online ahead of print.ABSTRACTDespite their widespread clinical use, oral corticosteroids (OCSs) are well known to be associated with a myriad of adverse effects, including immunosuppression. By inhibiting transcription factors and affecting leukocyte function, prolonged OCS use leads to significant CD4 lymphopenia, and also often leads to a decrease in serum IgG. Conversely, OCS use has minimal impact on circulating B cell, serum IgM, or serum IgA levels. Although there is a paucity of literature, individuals treated with prolo...
Source: Annals of Allergy, Asthma and Immunology - January 21, 2023 Category: Allergy & Immunology Authors: S Shahzad Mustafa Source Type: research

Vaccination before and after autologous hematopoietic cell transplantation  for autoimmune diseases: Guidances from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (MATHEC-SFGM-TC)
Bull Cancer. 2023 Jan 17:S0007-4551(22)00426-X. doi: 10.1016/j.bulcan.2022.11.005. Online ahead of print.ABSTRACTThe Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) organized the 12th workshop on hematopoietic stem cell transplantation clinical practices harmonization procedures on September 2021 in Lille, France. In the absence of specific national or international recommendation, the French working group for autologous stem Cell transplantation in Auto-immune Diseases (MATHEC) proposed guidances for vaccinations of patients undergoing autologous hematopoietic stem cell transplantation fo...
Source: Bulletin du Cancer - January 19, 2023 Category: Cancer & Oncology Authors: Alexandre Thibault Jacques Maria Arnaud Campidelli Cristina Castilla-Llorente Pauline Lansiaux Zora Marjanovic Gr égory Pugnet Jose Miguel Torregrosa-Diaz Louis Terriou Jean-Pierre Algayres Fanny Urbain Ibrahim Yakoub-Agha Dominique Farge Source Type: research

Fight Aging! Newsletter, January 16th 2023
Conclusions Implanted Hair Follicle Cells Produce Remodeling of Scar Tissue Assessment of Somatic Mosaicism as a Biomarker of Aging The Gut Microbiome of Centenarians https://www.fightaging.org/archives/2023/01/the-gut-microbiome-of-centenarians/ The state of the gut microbiome is arguably as influential on health as exercise. Various microbial species present in the gut produce beneficial metabolites, such as butyrate, or harmful metabolites, such as isoamylamine, or can provoke chronic inflammation in a variety of ways. An individual can have a better or worse microbiome, assessing these and other fu...
Source: Fight Aging! - January 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Recent progress in cancer immunotherapy: Overview of current status and challenges
Pathol Res Pract. 2022 Nov 24;241:154241. doi: 10.1016/j.prp.2022.154241. Online ahead of print.ABSTRACTCancer treatment is presently one of the most important challenges in medical science. Surgery, chemotherapy, radiotherapy, or combining these methods is used to eliminate the tumor. Hormone therapy, bone marrow transplantation, stem cell therapy as well as immunotherapy are other well-known therapeutic modalities. Immunotherapy, as the most important complementary method, uses the immune system for treating cancer followed by surgery, chemotherapy, and radiotherapy. This method is systematically used to prevent malignan...
Source: Pathology, Research and Practice - December 21, 2022 Category: Pathology Authors: Mohammad Darvishi Foad Tosan Pooria Nakhaei Danial Amiri Manjili Sahar Afzali Kharkouei Ali Alizadeh Saba Ilkhani Farima Khalafi Firoozeh Abolhasani Zadeh Seyyed-Ghavam Shafagh Source Type: research

Efficacy of Sinopharm Vaccine among Stem Cell Transplant Recipient during two peaks of Delta and Omicron variants of COVID-19
CONCLUSION: In summary, it seems that Sinopharm COVID-19 vaccine adverse effects were not serious among stem cell transplant recipients. However, it may lead to some severe complications in the population. Vaccine failure against the Delta and Omicron variants of COVID-19 has been reported among more than one-third of BMT patients; however, no mortality was observed among BMT patients infected with the new variants of COVID-19.PMID:35927906 | DOI:10.2174/1574886317666220801122822
Source: Current Drug Safety - August 5, 2022 Category: Drugs & Pharmacology Authors: Ali Ghasemi Rozita Khodashahi Mohsen Aliakbarian Ebrahim Khaleghi Baran Razmkhah Mehrsa Vahdatinia Mahdi Salimi Far Omolbanin Bakhti Source Type: research

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