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Therapy: Corticosteroid Therapy
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Total 30301 results found since Jan 2013.
A Double-Blind, Randomised, Placebo-controlled Trial of Long-Term Doxycycline Therapy on Exacerbation Rate in Patients with Stable COPD
CONCLUSIONS: Doxycycline did not significantly reduce exacerbation rate, over 12-months, in participants with COPD, who exacerbated regularly, but may have benefitted those with more severe COPD or blood eosinophil counts <300 cells/μL. Clinical trial registration available at www.CLINICALTRIALS: gov, ID: NCT02305940.PMID:37450935 | DOI:10.1164/rccm.202212-2287OC
Source: American Journal of Respiratory and Critical Care Medicine - July 14, 2023 Category: Respiratory Medicine Authors: James P Allinson Ben H Vlies Simon E Brill Martin Law Girvan Burnside Lydia J Finney Luana Alves-Moreira Gavin C Donaldson Peter M A Calverley Paul P Walker Jadwiga A Wedzicha Source Type: research
Hypothalamic–pituitary–adrenal function: anaesthetic implications
Publication date: October 2014 Source:Anaesthesia & Intensive Care Medicine, Volume 15, Issue 10 Author(s): Grainne Nicholson , George M. Hall Surgery, trauma and critical illness evoke a series of hormonal and metabolic changes commonly referred to as the stress response. Activation of the hypothalamic–pituitary–adrenal axis results in increased secretion of hormones such as cortisol. Anaesthesia can suppress adrenocortical secretion either by an effect at the hypothalamus, for example by a decrease in neural input with regional anaesthesia, or by a direct effect on the adrenal cortex, for example by etomida...
Source: Anaesthesia and intensive care medicine - October 12, 2014 Category: Anesthesiology Source Type: research
Predictors of 7- and 30-day mortality in pediatric intensive care unit patients with cancer and hematologic malignancy infected with Gram-negative bacteria
Conclusions Shock was a predictor of 7- and 30-day mortality, and colonization by multidrug resistant-Gram-negative bacteria was an important risk factor for 30-day mortality.
Source: The Brazilian Journal of Infectious Diseases - November 22, 2014 Category: Infectious Diseases Source Type: research
Reversible Increase in Maximal Cortisol Secretion Rate in Septic Shock*
Objective: Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness–related corticosteroid insufficiency. We sought to assess adrenocortical function using computer-assisted numerical modeling methodology to characterize and compare maximal cortisol secretion rate and free cortisol half-life in septic shock, sepsis, and healthy control subjects.
Design: Post hoc analysis of previously published total cortisol, free cortisol, corticosteroid-binding globulin, and albumin concentration data.
Sett...
Source: Critical Care Medicine - February 22, 2015 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research
Corticosteroid exposure in pediatric acute respiratory distress syndrome
Conclusions
Corticosteroid exposure >24 h was independently associated with fewer VFD and longer duration of ventilation in survivors, even after adjustment for key potential confounders, including severity of illness, oxygenation index, immunocompromised status, and number of organ failures.
Source: Intensive Care Medicine - July 9, 2015 Category: Intensive Care Source Type: research
Clinical review: intensive care unit acquired weakness
A substantial number of patients admitted to the ICU because of an acute illness, complicated surgery, severe trauma, or burn injury will develop a de novo form of muscle weakness during the ICU stay that is referred to as “intensive care unit acquired weakness” (ICUAW). This ICUAW evoked by critical illness can be due to axonal neuropathy, primary myopathy, or both. Underlying pathophysiological mechanisms comprise microvascular, electrical, metabolic, and bioenergetic alterations, interacting in a complex way and culminating in loss of muscle strength and/or muscle atrophy. ICUAW is typically symmetrical and affects ...
Source: Critical Care - August 5, 2015 Category: Intensive Care Authors: Greet HermansGreet Van den Berghe Source Type: research
What Is the Evidence for Harm of Neuromuscular Blockade and Corticosteroid Use in the Intensive Care Unit?
Abstract
Neuromuscular blocking agents and corticosteroids are widely used in medicine and in particular in the intensive care unit (ICU). Neuromuscular blockade is commonly used to ease tracheal intubation, to optimize mechanical ventilation and oxygenation in acute respiratory disorders such as status asthmaticus and acute respiratory distress syndrome (ARDS), to prevent shivering during therapeutic hypothermia, and also in patients with elevated intracranial pressure. In the ICU, patients with sepsis, ARDS, community-acquired pneumonia, exacerbation of chronic obstructive pulmonary disease, severe asthma, or tr...
Source: Respiratory Care - February 1, 2016 Category: Respiratory Medicine Authors: Annane D Tags: Semin Respir Crit Care Med Source Type: research
Understanding the Underlying Mechanisms of Hyponatremia in Coronavirus Disease 2019 Is Critical Since Treatment Varies Based on Etiology: Let Us Not Forget Critical Illness-Related Corticosteroid Insufficiency As the Treatment Is Very Different and Often Lifesaving!
No abstract available
Source: Critical Care Medicine - June 28, 2021 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research
Mortality Risk Factors for Invasive Candidiasis in Pediatric Intensive Care Unit
In this study, it was aimed to evaluate the mortality rate and risk factors affecting mortality in patients followed up with the diagnosis of invasive candidiasis in our pediatric intensive care unit. Patients who were between the ages of 1 month and 18 years followed up in the paediatric intensive care unit with invasive candidiasis between 2014 and 2018, were included in the study. The demographic characteristics of the patients, fever and hypotension, the Candida species, use of broad-spectrum antibiotics, blood transfusion, parenteral nutrition, invasive interventions, use of mechanical ventilation and laboratory test ...
Source: Mikrobiyoloji Bulteni - October 20, 2021 Category: Microbiology Authors: Ali Korulmaz Mehmet Alakaya Semra Erdo ğan Ali Ertu ğ Arslanköylü Didem Özgür Zehra Feza Ota ğ Source Type: research
