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Vaccination: Varicella-Zoster Virus Vaccine

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Total 265 results found since Jan 2013.

Herpes Zoster Ophthalmicus.
Abstract Herpes zoster is a commonly encountered disorder. It is estimated that there are approximately 1 million new cases of herpes zoster in the United States annually, with an incidence of 3.2 per 1000 person-years. Patients with HIV have the greatest risk of developing herpes zoster ophthalmicus compared with the general population. Other risk factors include advancing age, use of immunosuppressive medications, and primary infection in infancy or in utero. Vaccination against the virus is a primary prevention modality. Primary treatments include antivirals, analgesics, and anticonvulsants. Management may requ...
Source: Primary Care - September 1, 2015 Category: Primary Care Authors: Johnson JL, Amzat R, Martin N Tags: Prim Care Source Type: research

Herpes Zoster Ophthalmicus
Herpes zoster is a commonly encountered disorder. It is estimated that there are approximately 1 million new cases of herpes zoster in the United States annually, with an incidence of 3.2 per 1000 person-years. Patients with HIV have the greatest risk of developing herpes zoster ophthalmicus compared with the general population. Other risk factors include advancing age, use of immunosuppressive medications, and primary infection in infancy or in utero. Vaccination against the virus is a primary prevention modality. Primary treatments include antivirals, analgesics, and anticonvulsants. Management may require surgical inter...
Source: Primary Care: Clinics in Office Practice - August 26, 2015 Category: Primary Care Authors: Julie L. Johnson, Rianot Amzat, Nicolle Martin Source Type: research

Use of Saliva to Identify Varicella Zoster Virus Infection of the Gut
Conclusions. Detection of salivary VZV DNA in patients with abdominal pain helps to identify putative enteric zoster for investigation and treatment.
Source: Clinical Infectious Diseases - July 29, 2015 Category: Infectious Diseases Authors: Gershon, A. A., Chen, J., Gershon, M. D. Tags: ARTICLES AND COMMENTARIES Source Type: research

Herpes zoster ophthalmicus: declining age at presentation.
CONCLUSIONS: Ever since the introduction of varicella vaccination in children, there has been debate regarding its effect on zoster epidemiology, particularly regarding the potential to reduce population exposure and limit repeated immunological boosts against varicella zoster virus in adults. Patients presenting to MEEI with HZO were younger on average in 2013 than in 2007. Although a population-based study is necessary to test the hypothesis, our study suggests that varicella vaccination of children remains a possible explanation for the increased number of cases and reduction in mean age of newly diagnosed patients. ...
Source: The British Journal of Ophthalmology - July 15, 2015 Category: Opthalmology Authors: Davies EC, Langston DP, Chodosh J Tags: Br J Ophthalmol Source Type: research

Experimental new vaccine may help in the fight against shingles
If you had chickenpox as a child, the virus that caused it can re-emerge later in life — out of the blue — to cause shingles. This condition, also known as herpes zoster, consists of a rash on one side of the body, often accompanied by excruciating pain. The rash typically goes away in about a month, but in some people, the pain lingers for weeks, months, or even years. This chronic pain is called post-herpetic neuralgia. The virus that causes chickenpox, known as varicella-zoster, doesn’t necessarily disappear from the body after the chickenpox rash fades away. Instead, the virus can go into hiding, taking up re...
Source: New Harvard Health Information - May 4, 2015 Category: Consumer Health News Authors: Gregory Curfman, MD Tags: Vaccines HZ/su shingles varicella-zoster Zostavax Source Type: news

The Impact of 2-Dose Routine Measles, Mumps, Rubella, and Varicella Vaccination in France on the Epidemiology of Varicella and Zoster Using a Dynamic Model With an Empirical Contact Matrix.
In conclusion, the model predicted that MMRV vaccination can significantly reduce varicella incidence. With suboptimal coverage, a limited age shift of varicella cases is predicted to occur post-vaccination with MMRV. However, it does not result in an increase in the number of complications. GSK study identifier: HO-12-6924. PMID: 25726457 [PubMed - as supplied by publisher]
Source: Clinical Therapeutics - February 25, 2015 Category: Drugs & Pharmacology Authors: Ouwens MJ, Littlewood KJ, Sauboin C, Téhard B, Denis F, Boëlle PY, Alain S Tags: Clin Ther Source Type: research

Research and Reviews in the Fastlane 065
This study looked at how patients and doctors can use shared decision making to reduce in patient work ups for low risk chest pain. Using a chest pain decision aid, they reduced in patient work ups by 19%. The brilliance here is in the application of the theory of shared decision making and the knowledge transfer to patients using this system.Recommended by: Anand SwaminathanThe Best of the RestCardiology, Emergency MedicineBangalore S et al. Clinical outcomes with β-blockers for myocardial infarction: a meta-analysis of randomized trials. Am J Med. 2014;127(10):939-53. PMID: 24927909The pendulum for beta blockers in MI k...
Source: Life in the Fast Lane - January 7, 2015 Category: Emergency Medicine Authors: Anand Swaminathan Tags: Cardiology Education Emergency Medicine Intensive Care Pre-hospital / Retrieval Respiratory Resuscitation airway critical care R&R in the FASTLANE recommendations Review Trauma Source Type: blogs

Comparison of intramuscular and subcutaneous administration of a herpes zoster live-attenuated vaccine in adults aged ≥50 years: A randomised non-inferiority clinical trial.
Abstract Zostavax(®) is a live, attenuated varicella zoster virus (VZV) vaccine developed specifically for the prevention of HZ and PHN in individuals aged ≥50 years. During the clinical development of Zostavax, which was mainly in the US, the vaccine was administrated by the subcutaneous (SC) route. In Europe, many healthcare professionals prefer administering vaccines by the intramuscular (IM) route. This was an open-label, randomised trial conducted in 354 subjects aged ≥50 years. The primary objectives were to demonstrate that IM administration is both non-inferior to SC administration in terms of 4-week ...
Source: Vaccine - December 30, 2014 Category: Allergy & Immunology Authors: Diez-Domingo J, Weinke T, Garcia de Lomas J, Meyer CU, Bertrand I, Eymin C, Thomas S, Sadorge C Tags: Vaccine Source Type: research

Burden of herpes zoster-associated chronic pain in Italian patients aged 50 years and over (2009¿2010): a GP-based prospective cohort study
Conclusions: These results suggest that HZ and PHN represent an important burden of disease in the elderly. There is a need for interventions that can prevent and reduce the burden of HZ to help improve the quality of life of the elderly. These data may be useful as baseline epidemiology data for the assessment of the impact of the VZV vaccine in Italy, after its implementation.
Source: BMC Infectious Diseases - December 6, 2014 Category: Infectious Diseases Authors: Hélène BricoutEmilia PerinettiPaolo MarchettiniPietro RagniCarla ZottiGiovanni GabuttiAntonio VolpiElisabetta Franco Source Type: research

Postherpetic neuralgia in Europe: The scale of the problem and outlook for the future
This article provides a balanced overview of the important clinical and epidemiological studies carried out with respect to the definition, prevention, and treatment of this debilitating condition.
Source: Journal of Clinical Gerontology and Geriatrics - November 3, 2014 Category: Geriatrics Source Type: research

What Causes Neck Stiffness?
Discussion The complaint of neck stiffness always makes the clinician a little concerned until he/she understands the whole history because of the potential diagnosis of meningitis/encephalitis. While this potential is always concerning, there are many other causes of neck stiffness or pain to consider that are much more common. Normal wear and tear, injury or overuse that occur in daily activities and work can cause neck stiffness or pain. Often, even in adults, the cause of the pain is not recognized. Good examples are the adolescent above, or an innocent stumble, particularly if carrying something that may cause a perso...
Source: PediatricEducation.org - June 30, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Systematic review of incidence and complications of herpes zoster: towards a global perspective
Conclusions HZ is a significant global health burden that is expected to increase as the population ages. Future research with rigorous methods is important.
Source: BMJ Open - June 10, 2014 Category: Journals (General) Authors: Kawai, K., Gebremeskel, B. G., Acosta, C. J. Tags: Open access, Epidemiology, Global health, Infectious diseases Research Source Type: research

French National Health Authority recommends routine vaccination with Zostavax® to protect seniors against shingles
The French National High Council for Public Health (HCSP) has recommended routine shingles vaccination for seniors from 65 to 74 years of age. In addition, during the first year a catch-up will be proposed to 75-79 year-olds[1].The recommendation acknowledges the heavy burden of shingles and its often-associated condition, long-lasting pain called post-herpetic neuralgia. The High Council recognizes the significant scientific evidence that vaccination is the only health option that prevents both incidence and severity of disease.
Source: Health News from Medical News Today - December 19, 2013 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Live Attenuated Varicella-Zoster Vaccine in Hematopoietic Stem Cell Transplantation Recipients
We report our experience with using a single dose of VZV vaccine in 110 adult autologous and allogeneic HSCT recipients who were about 2 years after transplantation, free of graft-versus-host disease, and not receiving immunosuppression. One hundred eight vaccine recipients (98.2%) had no clinically apparent adverse events with a median follow-up period of 9.5 months (interquartile range, 6 to 16; range, 2 to 28). Two vaccine recipients (1.8%) developed a skin rash (one zoster-like rash with associated pain, one varicella-like) within 42 days post-vaccination that resolved with antiviral therapy. We could not confirm if...
Source: Biology of Blood and Marrow Transplantation - November 25, 2013 Category: Hematology Authors: Nicolas C. Issa, Francisco M. Marty, Houry Leblebjian, Alicia Galar, Margaret M. Shea, Joseph H. Antin, Robert J. Soiffer, Lindsey R. Baden Tags: Brief Articles Source Type: research

A case of meningitis due to varicella zoster virus reactivation in an immunocompetent child
Conclusion: VZV reactivation can also lead to various neurological complications in immunocompetent children. Prompt therapy with acyclovir and the integrity of the immune system are important in conditioning outcome, but other currently unknown factors probably also play a role.
Source: Italian Journal of Pediatrics - November 13, 2013 Category: Pediatrics Authors: Susanna EspositoSamantha BosisRaffaella PinzaniLaura MorlacchiLaura SenatoreNicola Principi Source Type: research