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Vaccination: Veterinary Vaccinations

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Total 8918 results found since Jan 2013.

Immunogenicity Comparison of a Next Generation Pneumococcal Conjugate Vaccine in Animal Models and Human Infants
Conclusions: These results demonstrate that PCV15 is immunogenic across multiple animal species, with IRM and human infants showing the best correlation for OPA responses.
Source: The Pediatric Infectious Disease Journal - December 20, 2019 Category: Infectious Diseases Tags: Translational Medicine Reports Source Type: research

Critical point for membrane bilayer formation
Biochim Biophys Acta Biomembr. 2023 Jan 11:184116. doi: 10.1016/j.bbamem.2022.184116. Online ahead of print.ABSTRACTUnilamellar liposomes often are employed in investigations of lipid-protein interactions and the delivery of drugs in therapies for disease. Also, related lipid-containing nanoparticles have been developed as elements of a new class of mRNA vaccines. We show that only unilamellar films form in equilibrium lipid dispersions, at temperature values {T*} that depend on the identities of the lipids (e.g., T* ≈ 29 °C for DMPC). Thermodynamic analysis confirms that films at air-water surfaces can be used to monit...
Source: Biochimica et Biophysica Acta - January 14, 2023 Category: Biochemistry Authors: Norman L Gershfeld Ralph Nossal Source Type: research

Rabies Post-Exposure Prophylaxis, What the U.S. Emergency Medicine Provider Needs to Know
Acad Emerg Med. 2023 May 27. doi: 10.1111/acem.14755. Online ahead of print.ABSTRACTApproximately 55,000 patients per year in the United States are exposed to potentially rabid animals and receive rabies post-exposure prophylaxis (PEP) and these patients commonly present to the emergency department for wound care and PEP. Despite the number of rabies exposures seen in emergency departments each year, there appears to be a knowledge gap among healthcare providers with regard to prescribing and administering rabies PEP. The following review aims to bridge that knowledge gap by discussing the importance of obtaining a compreh...
Source: Accident and Emergency Nursing - May 28, 2023 Category: Emergency Medicine Authors: Kyle Gibbons Kyle Dvoracek Source Type: research

A Critical Review and Meta‐Analysis of the Efficacy of Whole‐Cell Killed Tritrichomonas foetus Vaccines in Beef Cattle
This review assesses the efficacy of whole cell Tritrichomonas foetus vaccine to prevent and treat trichomoniasis in beef cattle. Three databases were searched in June 2012. Eligible studies compared infection risk, open risk, and abortion risk in heifers or infection risk in bulls that received vaccine compared with no vaccine. Study results were extracted, summary effect measures were calculated, and the quality of the evidence was assessed. From 334 citations identified, 10 were relevant to the review. For heifers, there was limited evidence of moderate quality to assess the impact of vaccination on infection risk (RR, ...
Source: Journal of Veterinary Internal Medicine - May 1, 2013 Category: Veterinary Research Authors: P. Baltzell, H. Newton, A.M. O'Connor Tags: Review Source Type: research

Anaphylaxis in dogs and cats
Abstract ObjectiveTo review and summarize current information regarding the pathophysiology and clinical manifestations associated with anaphylaxis in dogs and cats. The etiology, diagnosis, treatment, and prognosis is discussed. EtiologyAnaphylaxis is a systemic, type I hypersensitivity reaction that often has fatal consequences. Many of the principal clinical manifestations involve organs where mast cell concentrations are highest: the skin, the lungs, and the gastrointestinal tract. Histamine and other deleterious inflammatory mediators promote vascular permeability and smooth muscle contraction; they are readily releas...
Source: Journal of Veterinary Emergency and Critical Care - July 15, 2013 Category: Veterinary Research Authors: Daniella L. Shmuel, Yonaira Cortes Tags: Clinical Practice Review Source Type: research

Biosimilars Update: FDA Releases “Purple Book”; Two Companies File Biosimilar Applications, Industry Responds to Draft Guidance
Vaccines, allergy shots, blood components, and gene therapies are examples of biological products. Most biologics are produced in living organisms, such as plant or animal cells, whereas small molecule drugs (most pharmaceuticals) are typically manufactured through chemical synthesis. The inherently complex nature of biologics makes them expensive to develop and impossible to copy in the manner traditionally associated with the approval of generic drugs. BioSIMILAR, not BioEQUIVALENT Enter “biosimilars,” which the Food and Drug Administration (FDA) defines as biological products that are highly similar to an already ap...
Source: Policy and Medicine - September 15, 2014 Category: American Health Authors: Thomas Sullivan Source Type: blogs

Dog ecology, dog bites and rabies vaccination rates in Bauchi State, Nigeria
Publication date: June 2014 Source:International Journal of Veterinary Science and Medicine, Volume 2, Issue 1 Author(s): Y.J. Atuman , A.B. Ogunkoya , D.A.Y. Adawa , A.J. Nok , M.B. Biallah A study of dog ecology, dog bites and rabies vaccination rates was carried out in Bauchi the capital city of Bauchi State, Nigeria using direct street counts and questionnaire survey administered on 10% of the city streets selected by stratified random sampling. The questionnaire was designed to obtain data in order to determine the dog to human population ratio, dog management and care, cases of dog bites, consequences of the bites ...
Source: International Journal of Veterinary Science and Medicine - November 4, 2014 Category: Veterinary Research Source Type: research

A 51-Year-Old Woman Crushed by an Elephant Trunk
We report the case of a 51-year-old woman who sustained multiple systemic traumatic injuries after she was pinned to a fence by an elephant’s trunk. Upon arrival in the emergency department, she was hypothermic with a temperature of 35.1ºC (95.1ºF), hypotensive to 94/60 mm Hg after 5 L crystalloid, tachycardic at 108 beats/min, and intubated with oxygen saturation of 100%. Tranexamic acid was administered in addition to starting a massive transfusion protocol. Injuries included bilateral multiple rib fractures, left abdominal wall degloving injury, right pneumothorax, right hemothorax, left chest wall puncture wound, g...
Source: Wilderness and Environmental Medicine - November 6, 2014 Category: Environmental Health Source Type: research

Participatory methods for the assessment of the ownership status of free-roaming dogs in Bali, Indonesia, for disease control and animal welfare
Publication date: 1 September 2014 Source:Preventive Veterinary Medicine, Volume 116, Issues 1–2 Author(s): M.K. Morters , S. Bharadwaj , H.R. Whay , S. Cleaveland , I. Md. Damriyasa , J.L.N. Wood The existence of unowned, free-roaming dogs capable of maintaining adequate body condition without direct human oversight has serious implications for disease control and animal welfare, including reducing effective vaccination coverage against rabies through limiting access for vaccination, and absolving humans from the responsibility of providing adequate care for a domesticated species. Mark-recapture methods previously us...
Source: Preventive Veterinary Medicine - October 17, 2014 Category: Veterinary Research Source Type: research

Research Articles A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory
A protective vaccine against hepatitis C virus (HCV) remains an unmet clinical need. HCV infects millions of people worldwide and is a leading cause of liver cirrhosis and hepatocellular cancer. Animal challenge experiments, immunogenetics studies, and assessment of host immunity during acute infection highlight the critical role that effective T cell immunity plays in viral control. In this first-in-man study, we have induced antiviral immunity with functional characteristics analogous to those associated with viral control in natural infection, and improved upon a vaccine based on adenoviral vectors alone. We assessed a ...
Source: Science Translational Medicine - November 5, 2014 Category: Biomedical Science Authors: Swadling, L., Capone, S., Antrobus, R. D., Brown, A., Richardson, R., Newell, E. W., Halliday, J., Kelly, C., Bowen, D., Fergusson, J., Kurioka, A., Ammendola, V., Del Sorbo, M., Grazioli, F., Esposito, M. L., Siani, L., Traboni, C., Hill, A., Colloca, S. Tags: Research Articles Source Type: research

Ebola: translational science considerations
We are currently in the midst of the most aggressive and fulminating outbreak of Ebola-related disease, commonly referred to as ?Ebola?, ever recorded. In less than a year, the Ebola virus (EBOV, Zaire ebolavirus species) has infected over 10,000 people, indiscriminately of gender or age, with a fatality rate of about 50%. Whereas at its onset this Ebola outbreak was limited to three countries in West Africa (Guinea, where it was first reported in late March 2014, Liberia, where it has been most rampant in its capital city, Monrovia and other metropolitan cities, and Sierra Leone), cases were later reported in Nigeria, Mal...
Source: Journal of Translational Medicine - January 16, 2015 Category: Research Authors: Francesco ChiappelliAndre BakhordarianApril ThamesAngela DuAllison JanMelissa NahcivanMia NguyenNateli SamaErcolano ManfriniFrancesco PivaRafael RochaCarl Maida Source Type: research

The Slow and Ineffectual Path to Aging Interventions for Humans
A point I frequently make is that while there exists a wide range of potential approaches to the development of therapies to treat aging, it is important to divide these approaches into two buckets. Firstly there are potential therapies that aim to repair the root cause cellular and molecular damage that leads to degenerative aging, and which are in principle capable of rejuvenation, indefinite prevention of all age-related disease, and indefinite extension of healthy life. Whether any particular package of implemented therapies achieves this or not is a matter of how much damage is repaired: it depends on the effectivenes...
Source: Fight Aging! - January 28, 2015 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

The Lung Immune Niche in Tuberculosis: Insights from Studies on Human Alveolar Macrophages
Abstract Tuberculosis (TB) is a disease that continues to cause global mortality and morbidity. Transmission of Mycobacterium tuberculosis (Mtb) occurs by aerosol transmission from an infected case, making the lung the primary portal of entry for the bacterium. Alveolar macrophages are the frontline cells involved in the control of subsequent replication and spread of disease. Although animal models have provided important information in the field of macrophage immunology and cell biology, human TB disease has several unique features. Therefore, an understanding of human alveolar macrophage biology and their inter...
Source: Current Tropical Medicine Reports - April 22, 2015 Category: Tropical Medicine Source Type: research