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Vaccination: Influenza Vaccine

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Total 6499 results found since Jan 2013.

Pneumococcal conjugate vaccines for preventing otitis media.
CONCLUSIONS: Based on current evidence of the effects of PCVs for preventing AOM, the licensed 7-valent CRM197-PCV7 has modest beneficial effects in healthy infants with a low baseline risk of AOM. Administering PCV7 in high-risk infants, after early infancy and in older children with a history of AOM, appears to have no benefit in preventing further episodes. Currently, several RCTs with different (newly licensed, multivalent) PCVs administered during early infancy are ongoing to establish their effects on AOM. Results of these studies may provide a better understanding of the role of the newly licensed, multivalent PCVs ...
Source: Cochrane Database of Systematic Reviews - April 2, 2014 Category: Journals (General) Authors: Fortanier AC, Venekamp RP, Boonacker CW, Hak E, Schilder AG, Sanders EA, Damoiseaux RA Tags: Cochrane Database Syst Rev Source Type: research

Can Gingko and Turmeric Help Stop Ebola?
Summary There is no known pharmaceutical currently available that specifically treats Ebola disease. One treatment modality that should be considered is the use of herbal medicines, which have both centuries old anecdotal success as well as recent modern biochemical and formal research rationales for their use. Five areas of action that could be addressed by the herbal medicines as it relates to Ebola would be: VP24/immune system evasion GP protein/replicatio; herbal strategies effective against similar hemorrhagic disease beneficial modulation of patient immune and inflammatory response systems prophylactic use for heal...
Source: Inside Surgery - August 1, 2014 Category: Surgery Authors: Editor Tags: Infectious Disease ayurvedic baicalen cathepsin b dengue Ebola gingko herb Quercetin resveratrol rosemary sage st johns work turmeric Source Type: blogs

Strategies for addressing vaccine hesitancy - A systematic review.
Abstract The purpose of this systematic review is to identify, describe and assess the potential effectiveness of strategies to respond to issues of vaccine hesitancy that have been implemented and evaluated across diverse global contexts. METHODS: A systematic review of peer reviewed (January 2007-October 2013) and grey literature (up to October 2013) was conducted using a broad search strategy, built to capture multiple dimensions of public trust, confidence and hesitancy concerning vaccines. This search strategy was applied and adapted across several databases and organizational websites. Descriptive analy...
Source: Vaccine - April 17, 2015 Category: Allergy & Immunology Authors: Jarrett C, Wilson R, O'Leary M, Eckersberger E, Larson HJ, SAGE Working Group on Vaccine Hesitancy Tags: Vaccine Source Type: research

Influenza vaccines for preventing cardiovascular disease.
CONCLUSIONS: In patients with cardiovascular disease, influenza vaccination may reduce cardiovascular mortality and combined cardiovascular events. However, studies had some risk of bias, and results were not always consistent, so additional higher-quality evidence is necessary to confirm these findings. Not enough evidence was available to establish whether influenza vaccination has a role to play in the primary prevention of cardiovascular disease. PMID: 25940444 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - May 5, 2015 Category: Journals (General) Authors: Clar C, Oseni Z, Flowers N, Keshtkar-Jahromi M, Rees K Tags: Cochrane Database Syst Rev Source Type: research

Understanding factors influencing vaccination acceptance during pregnancy globally: A literature review.
Abstract Maternal vaccination has been evaluated and found to be extremely effective at preventing illness in pregnant women and new-borns; however, uptake of such programmes has been low in some areas. To analyse factors contributing to uptake of vaccines globally, a systematic review on vaccine hesitancy was carried out by The Vaccine Confidence Project in 2012. In order to further analyse factors contributing to uptake of maternal immunisation, a further search within the broader systematic review was conducted using the terms 'Pregnan*' or 'Matern*'. Forty-two articles were identified. Pregnancy-related articl...
Source: Vaccine - August 27, 2015 Category: Allergy & Immunology Authors: Wilson RJ, Paterson P, Jarrett C, Larson HJ Tags: Vaccine Source Type: research

FluKB: A Knowledge-Based System for Influenza Vaccine Target Discovery and Analysis of the Immunological Properties of Influenza Viruses.
Authors: Simon C, Kudahl UJ, Sun J, Olsen LR, Zhang GL, Reinherz EL, Brusic V Abstract FluKB is a knowledge-based system focusing on data and analytical tools for influenza vaccine discovery. The main goal of FluKB is to provide access to curated influenza sequence and epitope data and enhance the analysis of influenza sequence diversity and the analysis of targets of immune responses. FluKB consists of more than 400,000 influenza protein sequences, known epitope data (357 verified T-cell epitopes, 685 HLA binders, and 16 naturally processed MHC ligands), and a collection of 28 influenza antibodies and their struct...
Source: Journal of Immunology Research - October 30, 2015 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Conjugate Haemophilus influenzae type b vaccines for sickle cell disease.
CONCLUSIONS: There has been a dramatic decrease in the incidence of invasive Haemophilus influenzae type b infections observed in the post-vaccination era in people with sickle cell disease living in high-income countries. Therefore, despite the absence of evidence from randomised controlled trials, it is expected that Haemophilus influenzae type b conjugate vaccines may be useful in children affected with sickle cell disease, especially in African countries where there is a high prevalence of the disease. The implementation of childhood immunisation schedules, including universal Haemophilus influenzae type b conjugate va...
Source: Cochrane Database of Systematic Reviews - February 16, 2016 Category: Journals (General) Authors: Allali S, Chalumeau M, Launay O, Ballas SK, de Montalembert M Tags: Cochrane Database Syst Rev Source Type: research

Rationale for two influenza B lineages in seasonal vaccines: A meta-regression study on immunogenicity and controlled field trials.
Abstract B lineage mismatch prompted introduction of quadri-valent influenza vaccines (QIV) with two influenza B viruses representing distinct antigenic lineages. To explore the impact on antibody induction and vaccine effectiveness predicted from antibody (VEab), we performed a systematic literature search on immunogenicity studies conducted to assess antibody superiority of QIV over trivalent influenza vaccine (TIV). Thirteen relevant articles described 31 trials from 2007 and 2013. Log-transformed GMT trial estimates and their variances were converted to clinical protection rates predicted from antibody (PRab)....
Source: Vaccine - June 24, 2017 Category: Allergy & Immunology Authors: Beyer WEP, Palache AM, Boulfich M, Osterhaus ADME Tags: Vaccine Source Type: research

Key points in evaluating immunogenicity of pandemic influenza vaccines: A lesson from immunogenicity studies of influenza A(H1N1)pdm09 vaccine.
CONCLUSIONS: This review discusses factors and strategies that must be considered and addressed during immunogenicity assessments of pandemic influenza vaccines, which may provide useful information for future influenza pandemics. PMID: 28784284 [PubMed - as supplied by publisher]
Source: Vaccine - August 4, 2017 Category: Allergy & Immunology Authors: Ohfuji S, Kobayashi M, Ide Y, Egawa Y, Saito T, Kondo K, Ito K, Kase T, Maeda A, Fukushima W, Hirota Y Tags: Vaccine Source Type: research

Content and accuracy of vaccine information on pediatrician blogs.
CONCLUSIONS: Pediatrician bloggers frequently address vaccinations; most provide accurate information. Pediatrician blogs may be a new source to provide vaccine education to parents via social media. PMID: 29305176 [PubMed - as supplied by publisher]
Source: Vaccine - January 2, 2018 Category: Allergy & Immunology Authors: Bryan MA, Gunningham H, Moreno MA Tags: Vaccine Source Type: research

Fight Aging! Newsletter, May 14th 2018
This study found that professional chess players had shorter lifespans than those players who had careers outside of chess and argued that this might be due to the mental strain of international chess competition. In the present study, we focused on survival of International Chess Grandmasters (GMs) which represent players, of whom most are professional, at the highest level. In 2010, the overall life expectancy of GMs at the age of 30 years was 53.6 years, which is significantly greater than the overall weighted mean life expectancy of 45.9 years for the general population. In all three regions examined, mean life...
Source: Fight Aging! - May 13, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Influenza vaccine for chronic obstructive pulmonary disease (COPD).
CONCLUSIONS: It appeared, from the limited number of RCTs we were able to include, all of which were more than a decade old, that inactivated vaccine reduced exacerbations in people with COPD. The size of effect was similar to that seen in large observational studies, and was due to a reduction in exacerbations occurring three or more weeks after vaccination, and due to influenza. There was a mild increase in transient local adverse effects with vaccination, but no evidence of an increase in early exacerbations. Addition of live attenuated virus to the inactivated vaccine was not shown to confer additional benefit. PM...
Source: Cochrane Database of Systematic Reviews - June 26, 2018 Category: General Medicine Authors: Kopsaftis Z, Wood-Baker R, Poole P Tags: Cochrane Database Syst Rev Source Type: research

Conjugate Haemophilus influenzae type b vaccines for sickle cell disease.
CONCLUSIONS: There has been a dramatic decrease in the incidence of invasive Hib infections observed in the post-vaccination era in people with SCD living in high-income countries. Therefore, despite the absence of evidence from RCTs, it is expected that Hib conjugate vaccines may be useful in children affected with SCD, especially in African countries where there is a high prevalence of the disease. The implementation of childhood immunisation schedules, including universal Hib conjugate vaccination, may substantially improve the survival of children with SCD living in low-income countries. We currently lack data to evalu...
Source: Cochrane Database of Systematic Reviews - August 20, 2018 Category: General Medicine Authors: Allali S, Chalumeau M, Launay O, Ballas SK, de Montalembert M Tags: Cochrane Database Syst Rev Source Type: research

Quantitative Prediction of the Landscape of T Cell Epitope Immunogenicity in Sequence Space
This study indicates that targeting of epitopes by human adaptive immunity is to some extent directed by defined thermodynamic principles. The proposed framework also has a practical implication in that it may enable to more efficiently prioritize epitope candidates highly prone to T cell recognition in multiple individuals, warranting prospective validation across different cohorts. Introduction T cell epitopes bound to major histocompatibility complex [MHC; also called the human leukocyte antigen (HLA) in humans] molecules activate T cells to initiate subsequent immunological orchestration (1–3). MHC clas...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc
Conclusions and Perspectives In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human dis...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research