Filtered By:
Therapy: Antibiotic Therapy

This page shows you your search results in order of relevance. This is page number 14.

Order by Relevance | Date

Total 6680 results found since Jan 2013.

Effectiveness and safety of procalcitonin evaluation for reducing mortality in adults with sepsis, severe sepsis or septic shock.
CONCLUSIONS: Up-to-date evidence of very low to moderate quality, with insufficient sample power per outcome, does not clearly support the use of procalcitonin-guided antimicrobial therapy to minimize mortality, mechanical ventilation, clinical severity, reinfection or duration of antimicrobial therapy of patients with septic conditions. PMID: 28099689 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - January 17, 2017 Category: Journals (General) Authors: Andriolo BN, Andriolo RB, Salomão R, Atallah ÁN Tags: Cochrane Database Syst Rev Source Type: research

Update on surgical sepsis syndrome
ConclusionSepsis is an important and serious complication of surgery, and precautions must be taken to try to prevent infection in surgical patients. If sepsis develops, rapid diagnosis is crucial so that appropriate source control, antimicrobial therapy and organ support can be started early in the course of disease. New techniques enabling a better classification of a patient's particular sepsis profile will enable more personalized therapy.
Source: British Journal of Surgery - January 24, 2017 Category: Surgery Authors: J. ‐L. Vincent Tags: Review Source Type: research

Standard versus biofilm antimicrobial susceptibility testing to guide antibiotic therapy in cystic fibrosis.
CONCLUSIONS: The current evidence is insufficient to recommend choosing antibiotics based on biofilm antimicrobial susceptibility testing rather than conventional antimicrobial susceptibility testing in the treatment of Pseudomonas aeruginosa pulmonary infections in people with cystic fibrosis. Biofilm antimicrobial susceptibility testing may be more appropriate in the development of newer, more effective formulations of drugs which can then be tested in clinical trials. PMID: 28981972 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - October 5, 2017 Category: General Medicine Authors: Waters V, Ratjen F Tags: Cochrane Database Syst Rev Source Type: research

Does Antibiotic Treatment Affect the Diagnostic Accuracy of 18F-FDG PET/CT Studies in Patients with Suspected Infectious Processes?
Conclusion: 18F-FDG PET/CT correctly identified foci of increased uptake compatible with infection in most patients, including all patients receiving appropriate antimicrobial therapy, with no false-negative cases. On the basis of the current study results, the administration of antibiotics appears to have no clinically significant impact on the diagnostic accuracy of 18F-FDG PET/CT performed for evaluation of known or suspected infectious processes.
Source: Journal of Nuclear Medicine - November 1, 2017 Category: Nuclear Medicine Authors: Kagna, O., Kurash, M., Ghanem-Zoubi, N., Keidar, Z., Israel, O. Tags: Clinical Source Type: research

The cost of self-reported penicillin allergy: a systematic review
Conclusions Evaluations of clinical and economic outcomes of PCN allergy are primarily observational and focus on inpatient populations. Long-term relationships between PCN allergy and clinical and economic outcomes are unknown.
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 31, 2018 Category: Allergy & Immunology Source Type: research

Inhaled anti-pseudomonal antibiotics for long-term therapy in cystic fibrosis.
CONCLUSIONS: Inhaled anti-pseudomonal antibiotic treatment probably improves lung function and reduces exacerbation rate, but pooled estimates of the level of benefit were very limited. The best evidence is for inhaled tobramycin. More evidence from trials measuring similar outcomes in the same way is needed to determine a better measure of benefit. Longer-term trials are needed to look at the effect of inhaled antibiotics on quality of life, survival and nutritional outcomes. PMID: 29607494 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - March 30, 2018 Category: General Medicine Authors: Smith S, Rowbotham NJ, Regan KH Tags: Cochrane Database Syst Rev Source Type: research

Continuous versus intermittent antibiotics for bronchiectasis.
CONCLUSIONS: No randomised controlled trials have compared the effectiveness and risks of continuous antibiotic therapy versus intermittent antibiotic therapy for bronchiectasis. High-quality clinical trials are needed to establish which of these interventions is more effective for reducing the frequency and duration of exacerbations, antibiotic resistance and the occurrence of serious adverse events. PMID: 29860722 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - June 3, 2018 Category: General Medicine Authors: Donovan T, Felix LM, Chalmers JD, Milan SJ, Mathioudakis AG, Spencer S Tags: Cochrane Database Syst Rev Source Type: research

Dual antibiotics for bronchiectasis.
CONCLUSIONS: A small number of studies in adults have generated high-quality evidence that is insufficient to inform robust conclusions, and studies in children have provided no evidence. We identified only one dual-therapy combination of oral and inhaled antibiotics. Results from this single trial of 53 adults that we were able to include in the quantitative synthesis showed no evidence of treatment benefit with oral plus inhaled dual therapy in terms of successful treatment of exacerbations, serious adverse events, sputum volume, lung function, and antibiotic resistance. Further high-quality research is required to deter...
Source: Cochrane Database of Systematic Reviews - June 11, 2018 Category: General Medicine Authors: Felix LM, Grundy S, Milan SJ, Armstrong R, Harrison H, Lynes D, Spencer S Tags: Cochrane Database Syst Rev Source Type: research

The Cost of Self-Reported Penicillin Allergy: A Systematic Review
ConclusionsEvaluations of clinical and economic outcomes of PCN allergy are primarily observational and focus on inpatient populations. Long-term relationships between PCN allergy and clinical and economic outcomes are unknown.
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

Antibiotic therapy for skin and soft tissue infections: a protocol for a systematic review and network meta-analysis
This study has several strengths compared to previous reviews: inclusion of a wider range of infection types, antibiotics, and outcomes; a comprehensive search strategy; a priori subgroup analyses; application of GRADE; and improved interpretability of findings through visual presentation of results. We hope our findings will inform future research, health care professionals, and policy makers resulting in improved evidence-based clinical management of SSTIs.Systematic review registrationPROSPEROCRD42018085607
Source: Systematic Reviews - September 11, 2018 Category: International Medicine & Public Health Source Type: research

Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD).
CONCLUSIONS: Use of continuous and intermittent prophylactic antibiotics results in a clinically significant benefit in reducing exacerbations in COPD patients. All studies of continuous and intermittent antibiotics used macrolides, hence the noted benefit applies only to the use of macrolide antibiotics prescribed at least three times per week. The impact of pulsed antibiotics remains uncertain and requires further research.The studies in this review included mostly participants who were frequent exacerbators with at least moderate-severity COPD. There were also older individuals with a mean age over 65 years. The results...
Source: Cochrane Database of Systematic Reviews - October 30, 2018 Category: General Medicine Authors: Herath SC, Normansell R, Maisey S, Poole P Tags: Cochrane Database Syst Rev Source Type: research

C-reactive protein for diagnosing late-onset infection in newborn infants.
CONCLUSIONS: The serum CRP level at initial evaluation of an infant with suspected late-onset infection is unlikely to be considered sufficiently accurate to aid early diagnosis or select infants to undergo further investigation or treatment with antimicrobial therapy or other interventions. PMID: 30640979 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - January 14, 2019 Category: General Medicine Authors: Brown JVE, Meader N, Cleminson J, McGuire W Tags: Cochrane Database Syst Rev Source Type: research

Skull base osteomyelitis: factors implicating clinical outcome
In this study, we present our experience with seven patients diagnosed with skull base osteomyelitis that began with otitis externa and have been treated in our department for the last 10  years. Department Patient Database was searched for the diagnosis skull base osteomyelitis. The search covered the last 10 years. The search revealed seven patients who met the above-described criteria. Medical records of those patients were carefully analyzed including age, gender, symptoms and signs, diagnostics details, treatment, performed procedures, number of hospitalization days, comorbid diseases, and complications including an...
Source: Acta Neurologica Belgica - March 5, 2019 Category: Neurology Source Type: research

Protocol for a systematic review of time to antibiotics (TTA) in patients with fever and neutropenia during chemotherapy for cancer (FN) and interventions aiming to reduce TTA
This study aims to evaluate the association between TTA and patient-important clinical outcomes. Additionally, it will identify, critically appraise, and synthesise information on performed interventions and its effect to reduce TTA as a way of gaining insight into the potential use of these approaches. This will provide better knowledge for an adjusted treatment approach of FN.Systematic review registrationPROSPERO [CRD42018092948]
Source: Systematic Reviews - April 2, 2019 Category: International Medicine & Public Health Source Type: research