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Vaccination: Malaria Vaccine
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Total 1513 results found since Jan 2013.
Strategies for malaria vaccination during the COVID-19 pandemic in African countries
Bull World Health Organ. 2022 Oct 1;100(10):582-582A. doi: 10.2471/BLT.21.287472.NO ABSTRACTPMID:36188023 | PMC:PMC9511673 | DOI:10.2471/BLT.21.287472
Source: Bulletin of the World Health Organization - October 3, 2022 Category: International Medicine & Public Health Authors: Kapil Narain Sudhan Rackimuthu Faisal A Nawaz Osaretin Christabel Okonji Henry Ashworth Stefan S Du Plessis Jaffer Shah Source Type: research
Computational Clues of Immunogenic Hotspots in < em > Plasmodium falciparum < /em > Erythrocytic Stage Vaccine Candidate Antigens: In Silico Approach
Biomed Res Int. 2022 Oct 13;2022:5886687. doi: 10.1155/2022/5886687. eCollection 2022.ABSTRACTMalaria is the most pernicious parasitic infection, and Plasmodium falciparum is the most virulent species with substantial morbidity and mortality worldwide. The present in silico investigation was performed to reveal the biophysical characteristics and immunogenic epitopes of the 14 blood-stage proteins of the P. falciparum using comprehensive immunoinformatics approaches. For this aim, various web servers were employed to predict subcellular localization, antigenicity, allergenicity, solubility, physicochemical properties, post...
Source: Biomed Res - October 24, 2022 Category: Research Authors: Mojtaba Azimi-Resketi Saeed Heydaryan Niloufar Kumar Azin Takalou Reza Esmaeelzadeh Dizaji Bahman Noroozi Gorgani Morteza Shams Source Type: research
Licensed liposomal vaccines and adjuvants in the antigen delivery system
BioTechnologia (Pozn). 2022 Dec 24;103(4):409-423. doi: 10.5114/bta.2022.120709. eCollection 2022.ABSTRACTLiposomes (LSs) are promising nanoparticles with unique properties such as controlled nanosize, large surface area, increased reactivity, and ability to undergo modification. Worldwide, licensed liposomal forms of antibiotics, hormones, antioxidants, cytostatics, ophthalmic drugs, etc., are available on the pharmaceutical market. This review focuses on the adjuvant properties of LSs in the production of vaccines (VACs). LS-VACs have the following advantages: antigens with low immunogenicity can become highly immunogeni...
Source: Herpes - January 23, 2023 Category: Infectious Diseases Authors: Yuriy Krasnopolsky Daria Pylypenko Source Type: research
Meeting Summary: Global Vaccine and Immunization Research Forum, 2021
Vaccine. 2023 Feb 18:S0264-410X(23)00163-9. doi: 10.1016/j.vaccine.2023.02.028. Online ahead of print.ABSTRACTThe 2021 Global Vaccine and Immunization Research Forum highlighted the considerable advances and recent progress in research and development for vaccines and immunization, critically reviewed lessons learned from COVID-19 vaccine programs, and looked ahead to opportunities for this decade. For COVID-19, decades of investments in basic and translational research, new technology platforms, and vaccines targeting prototype pathogens enabled a rapid, global response. Unprecedented global coordination and partnership h...
Source: Vaccine - February 21, 2023 Category: Allergy & Immunology Authors: Andrew Ford Angela Hwang Annie X Mo Shahida Baqar Nancy Touchette Carolyn Deal Deborah King Kristen Earle Birgitte Giersing Peter Dull B Fenton Hall Source Type: research
Defining species-specific and conserved interactions of apical membrane protein 1 during erythrocyte invasion in malaria to inform multi-species vaccines
Cell Mol Life Sci. 2023 Feb 27;80(3):74. doi: 10.1007/s00018-023-04712-z.ABSTRACTPlasmodium falciparum and P. vivax are the major causes of human malaria, and P. knowlesi is an important additional cause in SE Asia. Binding of apical membrane antigen 1 (AMA1) to rhoptry neck protein 2 (RON2) was thought to be essential for merozoite invasion of erythrocytes by Plasmodium spp. Our findings reveal that P. falciparum and P. vivax have diverged and show species-specific binding of AMA1 to RON2, determined by a β-hairpin loop in RON2 and specific residues in AMA1 Loop1E. In contrast, cross-species binding of AMA1 to RON2 is re...
Source: Cellular and Molecular Life Sciences : CMLS - February 27, 2023 Category: Cytology Authors: Damien R Drew Danny W Wilson Gretchen E Weiss Lee M Yeoh Isabelle G Henshall Brendan S Crabb Sheetij Dutta Paul R Gilson James G Beeson Source Type: research
Large DNA fragment knock-in and sequential gene editing in Plasmodium falciparum: a preliminary study using suicide-rescue-based CRISPR/Cas9 system
Mol Cell Biochem. 2023 Apr 1:1-9. doi: 10.1007/s11010-023-04711-5. Online ahead of print.ABSTRACTCRISPR/Cas9 technology applied to Plasmodium falciparum offers the potential to greatly improve gene editing, but such expectations including large DNA fragment knock-ins and sequential gene editing have remained unfulfilled. Here, we achieved a major advance in addressing this challenge, especially for creating large DNA fragment knock-ins and sequential editing, by modifying our suicide-rescue-based system that has already been demonstrated to be highly efficient for conventional gene editing. This improved approach was confi...
Source: Molecular and Cellular Biochemistry - April 2, 2023 Category: Biochemistry Authors: Junnan Lu Ying Tong Rui Dong Yijun Yang Wen Hu Minghong Zhang Quan Liu Siting Zhao John H Adams Li Qin Xiaoping Chen Source Type: research
Clinical evaluation of commercial SARS-CoV-2 serological assays in a malaria endemic setting
J Immunol Methods. 2023 May 11:113488. doi: 10.1016/j.jim.2023.113488. Online ahead of print.ABSTRACTThe levels of immune response to SARS-CoV-2 infection or vaccination are poorly understood in African populations and is complicated by cross-reactivity to endemic pathogens as well as differences in host responsiveness. To begin to determine the best approach to minimize false positive antibody levels to SARS-CoV-2 in an African population, we evaluated three commercial assays, namely Bio-Rad Platelia SARS-CoV-2 Total Antibody (Platelia), Quanterix Simoa Semi-Quantitative SARS-CoV-2 IgG Antibody Test (anti-Spike), and the ...
Source: Journal of Immunological Methods - May 13, 2023 Category: Allergy & Immunology Authors: Djeneba Dabitao Kathryn Shaw-Saliba Drissa S Konate Helene C Highbarger Perrine Lallemand Ibrahim Sanogo Tauseef Rehman Mamadou Wague Nadie Coulibaly Bourahima Kone Bocar Baya Seidina A S Diakite Seydou Samake Esther Akpa Moctar Tounkara Sylvain Laverdure Source Type: research
HBV Infection Is an Intermediate-Risk Disease, Whereas Anaemia Is a Mild-to-Moderate Public Health Problem in Young Ghanaian Adults: A Four-Year Retrospective Analysis of Students' Medical Records
CONCLUSION: Intentional preventative public health campaigns regarding anaemia, HBV, and HCV infection should, respectively, target females and young adult males to increase chances of making real change in behavioural attitudes in these at-risk groups.PMID:37475793 | PMC:PMC10356218 | DOI:10.1155/2023/9318984
Source: Biomed Res - July 21, 2023 Category: Research Authors: Samuel Amoah Andrew Nicholas Yartey Praise Fosu Adjei Margaret Owusu-Akyaw Joseph Boachie David Larbi Simpong Patrick Adu Source Type: research
