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Vaccination: Vaccines

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Total 86788 results found since Jan 2013.

COVID-19 mouse model will speed search for drugs, vaccines
(Washington University School of Medicine) Researchers at Washington University School of Medicine in St. Louis have developed a mouse model of COVID-19 that is expected to speed up the search for drugs and vaccines for the potentially deadly disease.
Source: EurekAlert! - Infectious and Emerging Diseases - June 10, 2020 Category: Infectious Diseases Source Type: news

Computational search for potential COVID-19 drugs from FDAapproved drugs and small molecules of natural origin identifies several anti-virals and plant products.
Abstract The world is currently facing the COVID-19 pandemic, for which mild symptoms include fever and dry cough. In severe cases, it could lead to pneumonia and ultimately death in some instances. Moreover, the causative pathogen is highly contagious and there are no drugs or vaccines for it yet. The pathogen, SARS-CoV-2, is one of the human coronaviruses which was identified to infect humans first in December 2019. SARS-CoV-2 shares evolutionary relationship to other highly pathogenic viruses such as Severe Acute Respiratory Syndrome (SARS) and Middle East respiratory syndrome (MERS). We have exploited this sim...
Source: Journal of Biosciences - July 29, 2020 Category: Biomedical Science Authors: Sharma A, Tiwari V, Sowdhamini R Tags: J Biosci Source Type: research

Independent search engines respect your privacy but give more visibility to misinformation
(University of Sussex) Anti-vaccine websites, which could play a key role in promoting public hesitancy about a potential COVID vaccine, are far more likely to be found via independent search engines than through an internet giant like Google.
Source: EurekAlert! - Medicine and Health - August 13, 2020 Category: International Medicine & Public Health Source Type: news

South Africa: UCT Joins Search for Covid-19 Vaccine
[UCT] South Africa has joined global counterparts in search for a COVID-19 vaccine and the University of Cape Town (UCT) is lending a hand, participating in three international trials in the country, alongside several other universities.
Source: AllAfrica News: Health and Medicine - August 26, 2020 Category: African Health Source Type: news

In search of a vaccine against COVID-19: implications for nursing practice.
This article discusses the background to the current COVID-19 pandemic. The specific features of the causative pathogen (SARS-CoV-2) are outlined, together with a 'whistlestop' revision of immunological principles. The article goes on to discuss the principles and mechanisms of immunisation and the stages of vaccine development. The current situation in relation to the race to develop a vaccine against COVID-19 is incorporated and the immunological principles being adapted by the top contenders are outlined. These include new approaches based on genetic sequencing. Finally, the importance of understanding theoretical princ...
Source: British Journal of Nursing - September 9, 2020 Category: Nursing Authors: Boulton J Tags: Br J Nurs Source Type: research

Viruses, Vol. 13, Pages 106: Systematic Search for SARS-CoV-2 Main Protease Inhibitors for Drug Repurposing: Ethacrynic Acid as a Potential Drug
In this study we present systematic and integrative antiviral drug repurposing effort aimed at identifying, among the drugs already authorized for clinical use, some active inhibitors of the SARS-CoV-2 main protease. The most important result of this analysis is the demonstration that ethacrynic acid, a powerful diuretic, is revealed to be an effective inhibitor of SARS-CoV-2 main protease. Even with all the necessary cautions, given the particular nature of this drug, these data can be the starting point for the development of an effective therapeutic strategy against SARS-CoV-2.
Source: Viruses - January 13, 2021 Category: Virology Authors: Camilla Isgr ò Anna Maria Sardanelli Luigi Leonardo Palese Tags: Article Source Type: research

Ebolavirus: Comparison of Survivor Immunology and Animal Models in the Search for a Correlate of Protection
Ebola viruses are enveloped, single-stranded RNA viruses belonging to the Filoviridae family and can cause Ebola virus disease (EVD), a serious haemorrhagic illness with up to 90% mortality. The disease was first detected in Zaire (currently the Democratic Republic of Congo) in 1976. Since its discovery, Ebola virus has caused sporadic outbreaks in Africa and was responsible for the largest 2013–2016 EVD epidemic in West Africa, which resulted in more than 28,600 cases and over 11,300 deaths. This epidemic strengthened international scientific efforts to contain the virus and develop therapeutics and vaccines. Immunology...
Source: Frontiers in Immunology - February 19, 2021 Category: Allergy & Immunology Source Type: research

The CXCR5 T follicular helper cell compartment in children with antibody deficiencies-in search of a prognostic marker of childhood hypogammaglobulinemia
CONCLUSIONS: A deficiency of Tfh cells in young infants mirrors the immaturity of the humoral immune response, whereas in older children Tfh cells are proposed as a prognostic marker facilitating to distinguish between mild hypogammaglobulinemia and the developing common variable immunodeficiency.PMID:33641302 | DOI:10.15586/aei.v49i2.34
Source: Allergologia et Immunopathologia - February 28, 2021 Category: Allergy & Immunology Authors: Aleksandra Szczawinska-Poplonyk Katarzyna Tapolska-Jozwiak Husam Samara Maciej Boruczkowski Barbara Wieckowska Source Type: research