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OHSRP Education Series-Considerations for Informed Consent in Cell and Gene Therapy Trials
Our speaker for this presentation is Daniel Kavanagh, PhD, RAC (Regulatory Affairs Certification). He is Senior Scientific Advisor, Gene Therapy, Vaccines, and Biologics at WCG where he serves as a scientific and regulatory lead for gene transfer research. Prior to joining WCG, he was Assistant Professor of Medicine at Harvard Medical School, and Vice Chair of the MGH-Brigham Institutional Biosafety Committee. During this session, Dr. Kavanagh will address the following questions:• When a clinical trial involves gene therapy / human gene transfer research, what aspects of the informed consent process require special att...
Source: Videocast - All Events - September 22, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video

Benefits and Challenges of Remote Patient Monitoring as Perceived by Health Care Practitioners: A Systematic Review
Conclusion Health care practitioners generally believe that RPM is feasible for application. Additionally, there is a consensus that telemonitoring strategies will become increasingly relevant. However, there are still drawbacks to the technology that need to be considered.PMID:37735970 | DOI:10.7812/TPP/23.022
Source: The Permanente journal - September 22, 2023 Category: General Medicine Authors: Luiza Palmieri Serrano Karla C Maita Francisco R Avila Ricardo A Torres-Guzman John P Garcia Abdullah S Eldaly Clifton R Haider Christopher L Felton Margaret R Paulson Michael J Maniaci Antonio J Forte Source Type: research

Anesthetic management of a pediatric patient with methylmalonic acidemia combined with hyperhomocysteinemia: A case report
Patient of oncomitant esotropia with methylmalonic acidemia combined with hyperhomocysteinemia. Key Clinical MessageMethylmalonic acidemia (MMA) combined with hyperhomocysteinemia is an autosomal recessive genetic disease which can lead to metabolic acidosis, elevated lactate, and high blood ammonia level. This anesthetic management was mainly how to maintain the stable state of perioperative physiological metabolism of such patients.
Source: Clinical Case Reports - September 22, 2023 Category: General Medicine Authors: Yunting Pang, Fanqing Meng, Yaqiu Guo, Feng Zhou Tags: CASE REPORT Source Type: research

Pediatric chance fracture with seatbelt syndrome: A case report
A photograph of a seatbelt injury on a 6-year-old boy showcasing skin damage. Clinicians encountering this injury, known as the “seatbelt sign,” post-car accident, should be prompted to consider potential intra-abdominal organ injuries and spinal trauma. Key Clinical MessagePrompt recognition and accurate diagnosis of seatbelt-related injuries such as Chance fractures are crucial for pediatric patients. Clinicians should be aware of the unique characteristics of children, including the presence of growth plates, and use advanced imaging techniques such as magnetic resonance imaging to guide appropriate treatment and mi...
Source: Clinical Case Reports - September 22, 2023 Category: General Medicine Authors: Hirohito Hirata, Tadatsugu Morimoto, Masatsugu Tsukamoto, Takaomi Kobayashi, Tomohito Yoshihara, Yu Toda, Masaaki Mawatari Tags: CASE REPORT Source Type: research

The Emerging Roles and Mechanisms of PAQR3 in Human Cancer: Pathophysiology and Therapeutic Implications
Source: International Journal of General Medicine - September 22, 2023 Category: General Medicine Tags: International Journal of General Medicine Source Type: research

Sex-specific differences in physical health and health services use among Canadian Veterans: a retrospective cohort study using healthcare administrative data
Conclusions Female Veterans residing in Ontario, Canada have different chronic health risks and engage in health services use more frequently than their male counterparts. These findings have important healthcare policy and programme planning implications, in order to ensure female Veterans have access to appropriate health services.
Source: Journal of the Royal Army Medical Corps - September 22, 2023 Category: General Medicine Authors: St Cyr, K., Aiken, A. B., Cramm, H., Whitehead, M., Kurdyak, P., Mahar, A. L. Tags: Open access Original research Source Type: research

Collective aeromedical evacuations of SARS-CoV-2-related ARDS patients in a military tactical plane: a retrospective descriptive study
After the appearance of the COVID-19 pandemic in France, MEROPE system was created to transform the military tactical ATLAS A400M aircraft into a flying intensive care unit. Collective aeromedical evacuations (aero-MEDEVAC) of patients suffering from SARS-CoV-2-related acute respiratory distress syndrome was performed from June to December 2020. A total of 22 patients were transported during seven missions. All aero-MEDEVAC was performed in safe conditions for patients and crew. No life-threatening conditions occurred during flight. Biohazard controls were applied according to French guidelines and prevented crew contamina...
Source: Journal of the Royal Army Medical Corps - September 22, 2023 Category: General Medicine Authors: Martinez, T., Simon, K., Lely, L., Nguyen Dac, C., Lefevre, M., Aloird, P., Leschiera, J., Strehaiano, S., Nespoulous, O., Boutonnet, M., Raynaud, L. Tags: COVID-19 Personal view Source Type: research

Remote ultrasound diagnostics disrupting traditional military frontline healthcare delivery
This report discusses the first use of a consultant radiologist guiding a clinician, untrained in ultrasound, to perform an ultrasound scan via a live tele-guidance feed in the deployed environment using the Butterfly iQ+ tele-guidance system. Distance scanning provided a diagnostic quality report when compared with locally performed imaging to improve patient care and maintain operational output. This example demonstrates feasibility of remote point-of-care imaging systems in provision of location-agnostic high-quality diagnostic capability. Future opportunities to develop care pathways using bedside tele-diagnostics will...
Source: Journal of the Royal Army Medical Corps - September 22, 2023 Category: General Medicine Authors: Blenkinsop, G., Heller, R. A., Carter, N. J., Burkett, A., Ballard, M., Tai, N. Tags: Personal view Source Type: research

Can Defence be assured that future civilian specialty training programmes will produce suitably qualified and experienced military doctors?
UK Defence’s doctors receive the majority of their pre-accreditation clinical training within the National Health Service’s (NHS) specialty training programmes. These are designed primarily to serve the needs of a civilian patient population and are undergoing changes. Examination of these changes in relation to the training requirements of Defence’s doctors, suggests that future NHS training programmes present both opportunity and threat to the provision of competent military consultants and general practitioners (GPs). Opportunity to more easily integrate military-specific courses, experience and module...
Source: Journal of the Royal Army Medical Corps - September 22, 2023 Category: General Medicine Authors: McPhail, S. Tags: Personal view Source Type: research

Parenteral medications at Role 1: do doctors in the British Army require improved training and experience?
This article explores the current training of Role 1 doctors, the threat of skill fade and how the safety of drug administration can be improved. This includes recommendations for the development of training competencies, bespoke courses and clinical placements, e-learning and the use of new technology. Application of these recommendations has the potential to improve patient safety and the confidence of doctors in the use of parenteral analgesia.
Source: Journal of the Royal Army Medical Corps - September 22, 2023 Category: General Medicine Authors: Turner, L. J., Martin-Bates, A. J. Tags: Personal view Source Type: research

Sclerosing angiomatoid nodular transformation of the spleen in a child with anemia: a case report and  review of the literature
ConclusionAlthough sclerosing angiomatoid nodular transformation is exceedingly rare in children, it should be considered a differential diagnosis in pediatric splenic neoplasms with concurrent hematologic manifestations, such as anemia.
Source: Journal of Medical Case Reports - September 22, 2023 Category: General Medicine Source Type: research

Survey of Laboratory Medicine ’s national response to the HSE cyberattack in the Republic of Ireland
ConclusionThe cyberattack burdened the HSE and laboratories at a time when healthcare staffs were coming to terms with the impact of the COVID-19 pandemic. Despite this, the survey confirms the agility of laboratory staff in meeting the demands placed on it during this time.
Source: Irish Journal of Medical Science - September 22, 2023 Category: General Medicine Source Type: research

The Cardiovascular Burden of Rheumatoid Arthritis – Implications for Treatment
Mortality in rheumatoid arthritis is increased, about twice vs. controls, and cardiovascular diseases are a major cause. The pathogenesis is primarily accelerated atherosclerosis of the coronary, cervical, and cerebral arteries which is premature, pervasive, and progressive but often occult, under-recognized and under-treated. It is mostly driven by the chronic, systemic autoimmune inflammation but increased prevalence of traditional risk factors and adverse effects of treatments are also very important.
Source: The American Journal of Medicine - September 22, 2023 Category: General Medicine Authors: Ami Schattner Tags: Review Source Type: research

Unravelling a mysterious skin lesion in a patient with Ulcerative Colitis
A 53-year-old male with a history of long-standing ulcerative colitis presented to the emergency department with pain and swelling in his left lower extremity. He was diagnosed 12 years prior to the presentation with ulcerative colitis. He was initially managed with mesalamine for 5 years after which he lost response. For the following 6 years, he was placed on multiple immunosuppressive medications including adalimumab, infliximab, and mirikizumab. He remained symptomatic despite these medications.
Source: The American Journal of Medicine - September 22, 2023 Category: General Medicine Authors: Khaled Al-Smadi, Ammar Qureshi, Hasan Sqour, Ruijun Jeanna Su, Zeid Kayali Tags: Diagnostic Dilemma Source Type: research

Medical Misnomers are Murky: Time to Memorialize and Rename
Misnomers have dogged medical practice seemingly since its inception. They may arise out of initial misunderstanding of the underlying disease process, a fanciful personification of the disease itself, or simple confusion encountered early in the disease's discovery. Misnomers are not harmless. By increasing unneeded complexity, they add to challenges in medical education without increasing understanding. Practicing clinicians may experience difficulties in communicating with patients. For example, a diagnosis of “ringworm” may be made but the patient may not understand why an antiparasitic is not being prescribed, req...
Source: The American Journal of Medicine - September 22, 2023 Category: General Medicine Authors: Richie Manikat, Sanjiv Chopra Tags: Review Source Type: research