Unravelling a mysterious skin lesion in a patient with Ulcerative Colitis

A 53-year-old male with a history of long-standing ulcerative colitis presented to the emergency department with pain and swelling in his left lower extremity. He was diagnosed 12 years prior to the presentation with ulcerative colitis. He was initially managed with mesalamine for 5 years after which he lost response. For the following 6 years, he was placed on multiple immunosuppressive medications including adalimumab, infliximab, and mirikizumab. He remained symptomatic despite these medications.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Diagnostic Dilemma Source Type: research