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Specialty: Allergy & Immunology
Nutrition: Vitamin A
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Total 334 results found since Jan 2013.
Alterations of fecal microbiome and metabolome in pemphigus patients
J Autoimmun. 2023 Sep 13:103108. doi: 10.1016/j.jaut.2023.103108. Online ahead of print.ABSTRACTThe role of gut microbiome and metabolic substances in the development of autoimmune diseases has gradually been revealed. However, the relevant gut features in pemphigus have not been well clarified. We collected stool samples from pemphigus patients and healthy controls (HCs). Metagenomic sequencing and liquid chromatography-mass spectrometry (LC/MS) metabolome sequencing were performed to analyze the compositional and metabolic alternations of the gut microbiome in pemphigus patients and HCs. We observed the reduced richness ...
Source: Journal of Autoimmunity - September 15, 2023 Category: Allergy & Immunology Authors: Ziyu Guo Nam Yiu Zhi Hu Wenyu Zhou Xuan Long Miao Yang Jieyue Liao Guiying Zhang Qianjin Lu Ming Zhao Source Type: research
Punctate inner choroidopathy in common variable immunodeficiency associated with a pathogenic variant in the tumour necrosis factor receptor superfamily 13b (TNFRSF13B) gene - Case report and review of the literature
CONCLUSION: Autoimmunity may be the dominant clinical presenting feature of CVID. Punctuate inner choroidopathy is an idiopathic inflammatory chorioretinopathy, and to the best of our knowledge, has not been previously reported in CVID. A better understanding of the molecular bases of autoimmune diseases in CVID may provide novel therapeutic targets for autoimmune diseases in this patient population.PMID:37652172 | DOI:10.1016/j.clim.2023.109748
Source: Clinical Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Hiba Mohammed Hussein Salih Kelvin Cheng Kah Wai Justin McKee Charu Chopra Source Type: research
Complement factor I: Regulatory nexus, driver of immunopathology, and therapeutic
Immunobiology. 2023 Jun 5;228(5):152410. doi: 10.1016/j.imbio.2023.152410. Online ahead of print.ABSTRACTComplement factor I (FI) is the nexus for classical, lectin and alternative pathway complement regulation. FI is an 88 kDa plasma protein that circulates in an inactive configuration until it forms a trimolecular complex with its cofactor and substrate whereupon a structural reorganization allows the catalytic triad to cleave its substrates, C3b and C4b. In keeping with its role as the master complement regulatory enzyme, deficiency has been linked to immunopathology. In the setting of complete FI deficiency, a consumpt...
Source: Immunobiology - July 21, 2023 Category: Allergy & Immunology Authors: T M Hallam S J Sharp A Andreadi D Kavanagh Source Type: research
The Endogenous Retinoic Acid Receptor Pathway Is Exploited by Mycobacterium tuberculosis during Infection, Both In Vitro and In Vivo
J Immunol. 2023 Jul 3:ji2200555. doi: 10.4049/jimmunol.2200555. Online ahead of print.ABSTRACTRetinoic acid (RA) is a fundamental vitamin A metabolite involved in regulating immune responses through the nuclear RA receptor (RAR) and retinoid X receptor. While performing experiments using THP-1 cells as a model for Mycobacterium tuberculosis infection, we observed that serum-supplemented cultures displayed high levels of baseline RAR activation in the presence of live, but not heat-killed, bacteria, suggesting that M. tuberculosis robustly induces the endogenous RAR pathway. Using in vitro and in vivo models, we have furthe...
Source: Journal of Immunology - July 3, 2023 Category: Allergy & Immunology Authors: Yonne Karoline Ten ório de Menezes Carolina Eto Joseana de Oliveira Erica C Larson Daniel A G B Mendes Greicy Brisa Malaquias Dias Murilo Delgobo Abigail K Gubernat Janelle L Gleim Eduarda La ís Munari Marick Starick Fabienne Ferreira Daniel Santos Mans Source Type: research
ATRA ameliorates fibrosis by suppressing the pro-fibrotic molecule Fra2/AP-1 in systemic sclerosis
In this study, the pro-fibrotic effect of Fra2 in SSc is confirmed. SSc dermal fibroblasts and bleomycin-induced fibrotic tissues of SSc animals exhibit increased levels of Fra2. Inhibition of Fra2 expression in SSc dermal fibroblasts with Fra2 siRNA markedly decreased collagen I expression. ATRA reduced the expressions of Fra2, collagen I, and α-smooth muscle actin(α-SMA) in SSc dermal fibroblasts and bleomycin-induced fibrotic tissues of SSc mice. In addition, chromatin immunoprecipitation and dual-luciferase assays demonstrated that retinoic acid receptor RARα binds to the FRA2 promoter and modulates its transcriptio...
Source: International Immunopharmacology - June 18, 2023 Category: Allergy & Immunology Authors: Zixin Pi Jiani Liu Yangfan Xiao Xinglan He Ruixuan Zhu Rui Tang Xiangning Qiu Yi Zhan Zhuotong Zeng Yaqian Shi Rong Xiao Source Type: research
Melatonin protects against NMDA-induced retinal ganglion cell injury by regulating the microglia-TNF α-RGC p38 MAPK pathway
This study assessed the protective effects of melatonin using a NMDA-induced RGC injury model, and studied the possible mechanisms involved in this process. Melatonin promoted RGC survival, improved retinal function, and inhibited the apoptosis and necrosis of retinal cells. To understand the mechanism of the neuroprotective effects of melatonin on RGC, microglia and inflammation-related pathways were assessed after melatonin administration and microglia ablation. Melatonin promoted RGC survival by suppressing microglia-derived proinflammatory cytokines, in particular TNFα, which in turn inhibited the activation of p38 MA...
Source: International Immunopharmacology - April 26, 2023 Category: Allergy & Immunology Authors: Jingling Zou Jia Yang Biyue Chen Jikuan Jiang Jingyuan Liu Cong Wang Juan Yu Qinghua Peng Jun Zeng Lusi Zhang Bing Jiang Source Type: research
Vitreoretinal Surgery in Uveitis: From Old to New Concepts - A Review
CONCLUSION: Over the years, pars plana vitrectomy has undergone significant transformations since its invention nearly 5 decades ago, however, the quality of evidence in the literature regarding its use for uveitis has not improved in the same way. Even though some structural uveitis complications (as previously mentioned) may respond well to surgery, there is still a certain unpredictability regarding its visual outcomes. On the other hand, diagnostic vitrectomy with appropriate ancillary testing is also a valuable tool for the assessment and diagnosis of uveitis in a large proportion of patients.PMID:37093650 | DOI:10.10...
Source: Ocular Immunology and Inflammation - April 24, 2023 Category: Allergy & Immunology Authors: Thiago Jos é Muniz Machado Mazzeo Raimunda Cristina Mendon ça Freire Cleide Guimar ães Machado Andr é Marcelo Vieira Gomes Andr é Luiz Land Curi Source Type: research
