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Nutrition: Sodium
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Exposure to metam sodium-based pesticide impaired cognitive performances in adult mice: Involvement of oxidative damage and glial activation
Toxicol Appl Pharmacol. 2023 Sep 5:116677. doi: 10.1016/j.taap.2023.116677. Online ahead of print.ABSTRACTCognitive integrity is a critical aspect of neurological function, and a decline in cognitive function is a hallmark of neurotoxicity. Oxidative stress is a significant pathological feature contributing to cognitive deficits that can arise from exposure to environmental pollutants such as pesticides. Among these, Metam sodium-based pesticides (MS-BP) are an emergent type of pesticide widely used in the agriculture and public health sectors for controlling pests and diseases. Our prior research has shown that animals ex...
Source: Toxicology and Applied Pharmacology - September 7, 2023 Category: Toxicology Authors: Nour-Eddine Kaikai Saadia Ba-M'hamed Abderrazzak Ghanima Mohamed Bennis Source Type: research
GABA < sub > B1 < /sub > Receptor Knockdown in Prefrontal Cortex Induces Behavioral Aberrations Associated with Autism Spectrum Disorder in Mice
Brain Res Bull. 2023 Sep 5:110755. doi: 10.1016/j.brainresbull.2023.110755. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is a set of heterogeneous neurodevelopmental disorders, characterized by social interaction deficit, stereotyped or repetitive behaviors. Apart from these core symptoms, a great number of individuals with ASD exhibit higher levels of anxiety and memory deficits. Previous studies demonstrate pronounced decrease of γ-aminobutyric acid B1 receptor (GABAB1R) protein level of frontal lobe in both ASD patients and animal models. The aim of the present study was to determine the role of GABAB1R...
Source: Brain Research Bulletin - September 7, 2023 Category: Neurology Authors: Xiaona Wang Zhengqin Zhao Jisheng Guo Daoqi Mei Yongtao Duan Yaodong Zhang Lingshan Gou Source Type: research
Effect of Laparoscopic Soave Combined with Deloyers Turnover on the Efficacy and Prognosis of Children with Congenital Hirschsprung's Disease
CONCLUSION: Joint Deloyers flip Soave under laparoscopic surgery for children with congenital Hirschsprung disease has a better curative effect, with shorter operation time, less blood loss compared to traditional open surgery.PMID:37678856
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Daliu Chen Yongchun Du Source Type: research
A curcumin oral delivery system based on sodium caseinate and carboxymethylpachymaran nanocomposites
In conclusion, using CMP and sodium caseinate as carriers in this study may open up a fresh, environmentally friendly, and long-lasting way to construct a bioactive material delivery system.PMID:37678690 | DOI:10.1016/j.ijbiomac.2023.126698
Source: International Journal of Biological Macromolecules - September 7, 2023 Category: Biochemistry Authors: Lan Wang Jin Mao Qi Zhou Qianchun Deng Lei Zheng Jie Shi Source Type: research
GABA < sub > B1 < /sub > Receptor Knockdown in Prefrontal Cortex Induces Behavioral Aberrations Associated with Autism Spectrum Disorder in Mice
Brain Res Bull. 2023 Sep 5:110755. doi: 10.1016/j.brainresbull.2023.110755. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is a set of heterogeneous neurodevelopmental disorders, characterized by social interaction deficit, stereotyped or repetitive behaviors. Apart from these core symptoms, a great number of individuals with ASD exhibit higher levels of anxiety and memory deficits. Previous studies demonstrate pronounced decrease of γ-aminobutyric acid B1 receptor (GABAB1R) protein level of frontal lobe in both ASD patients and animal models. The aim of the present study was to determine the role of GABAB1R...
Source: Brain Research - September 7, 2023 Category: Neurology Authors: Xiaona Wang Zhengqin Zhao Jisheng Guo Daoqi Mei Yongtao Duan Yaodong Zhang Lingshan Gou Source Type: research
Effect of canagliflozin in non-diabetic obese patients with albuminuria: A randomized, double-blind, placebo-controlled trial
CONCLUSION: Canagliflozin 100 mg daily was well tolerated but did not significantly reduce UACR in non-diabetic obese patients with microalbuminuria. However, a significant temporary decline in eGFR might reflect a subtle reduction in glomerular hyperfiltration.PMID:37675488 | DOI:10.5414/CN111143
Source: Clinical Nephrology - September 7, 2023 Category: Urology & Nephrology Authors: Primploy Greeviroj Pongpratch Puapatanakul Jeerath Phannajit Kullaya Takkavatakarn Wonngarm Kittanamongkolchai Patchaya Boonchaya-Anant Pisut Katavetin Kearkiat Praditpornsilpa Somchai Eiam-Ong Paweena Susantitaphong Source Type: research
GABA < sub > B1 < /sub > receptor knockdown in prefrontal cortex induces behavioral aberrations associated with autism spectrum disorder in mice
Brain Res Bull. 2023 Sep 7;202:110755. doi: 10.1016/j.brainresbull.2023.110755. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is a set of heterogeneous neurodevelopmental disorders, characterized by social interaction deficit, stereotyped or repetitive behaviors. Apart from these core symptoms, a great number of individuals with ASD exhibit higher levels of anxiety and memory deficits. Previous studies demonstrate pronounced decrease of γ-aminobutyric acid B1 receptor (GABAB1R) protein level of frontal lobe in both ASD patients and animal models. The aim of the present study was to determine the role of GAB...
Source: Brain Research - September 7, 2023 Category: Neurology Authors: Xiaona Wang Zhengqin Zhao Jisheng Guo Daoqi Mei Yongtao Duan Yaodong Zhang Lingshan Gou Source Type: research
Employing the sustained-release properties of poly(lactic-co-glycolic acid) nanoparticles to reveal a novel mechanism of sodium-hydrogen exchanger 1 in neuropathic pain
Transl Res. 2023 Sep 5:S1931-5244(23)00143-3. doi: 10.1016/j.trsl.2023.09.003. Online ahead of print.ABSTRACTNeuropathic pain is caused by injury or disease of the somatosensory system, and its course is usually chronic. Several studies have been dedicated to investigating neuropathic pain-related targets; however, little attention has been paid to the persistent alterations that these targets, some of which may be crucial to the pathophysiology of neuropathic pain. The present study aimed to identify potential targets that may play a crucial role in neuropathic pain and validate their long-term impact. Through bioinformat...
Source: Translational Research : the journal of laboratory and clinical medicine - September 7, 2023 Category: Laboratory Medicine Authors: Junhua Wu Meiling Jin Quangdon Tran Minwoo Kim Song I Kim Juhee Shin Hyewon Park Nara Shin Hyunji Kang Hyo Jung Shin Sun Yeul Lee Song-Biao Cui C Justin Lee Won Hyung Lee Dong Woon Kim Source Type: research
Effects of Charged Surfactants on Interfacial Water Structure and Macroscopic Properties of the Air-Water Interface
Chemphyschem. 2023 Sep 7:e202300062. doi: 10.1002/cphc.202300062. Online ahead of print.ABSTRACTSurfactants are used to control the macroscopic properties of air-water interfaces. However, the link between the molecular structure of surfactant adsorption and macroscopic properties is poorly understood. Using sum-frequency generation spectroscopy and molecular dynamics simulation, we show that two ionic surfactants (dodecyl trimethylammonium bromide and sodium dodecyl sulphate) with the same carbon chain lengths and head group charge magnitude (but different signs) can interact and reorient interfacial water molecules diffe...
Source: Chemphyschem - September 7, 2023 Category: Chemistry Authors: Thao Nguyen Foad Raji Cuong Nguyen Ngoc Nguyen Anh V Nguyen Source Type: research
Do SGLT2 inhibitors and GLP-1 receptor agonists modulate differently the risk of stroke ? Discordance between randomised controlled trials and observational studies
Diabetes Metab. 2023 Sep 5:101474. doi: 10.1016/j.diabet.2023.101474. Online ahead of print.ABSTRACTStroke represents a major burden in patients with type 2 diabetes, yet this cerebrovascular complication has been less carefully investigated than the risk of cardiovascular mortality, heart failure and renal disease. Some data suggested that glucagon peptide-1 receptor agonists (GLP-1RAs) exert a better protection against stroke than sodium-glucose cotransporter 2 inhibitors (SGLT2is). However, this conclusion was derived from indirect comparisons in absence of any head-to-head randomised controlled trial (RCT). The present...
Source: Diabetes and Metabolism - September 7, 2023 Category: Endocrinology Authors: Andr é J Scheen Source Type: research
Excessive dietary sodium intake augments long-term risk of atrial fibrillation in older adults with hyperglycemia: A community-based prospective cohort study
CONCLUSION: Our findings indicate that excessive sodium intake independently enhances the risk of new-onset AF among patients with hyperglycemia. A sodium-restricted diet may perhaps result in a multiplier effect on reducing the risk of new-onset AF.PMID:37678758 | DOI:10.1016/j.diabet.2023.101475
Source: Diabetes and Metabolism - September 7, 2023 Category: Endocrinology Authors: Qin Zhang Yuqi Guo Mei Li Ruizhen Yang Yanli Yao Yingxin Zhao Haipeng Yin Hua Zhang Weike Liu Zhendong Liu Source Type: research
Effects of Charged Surfactants on Interfacial Water Structure and Macroscopic Properties of the Air-Water Interface
Chemphyschem. 2023 Sep 7:e202300062. doi: 10.1002/cphc.202300062. Online ahead of print.ABSTRACTSurfactants are used to control the macroscopic properties of air-water interfaces. However, the link between the molecular structure of surfactant adsorption and macroscopic properties is poorly understood. Using sum-frequency generation spectroscopy and molecular dynamics simulation, we show that two ionic surfactants (dodecyl trimethylammonium bromide and sodium dodecyl sulphate) with the same carbon chain lengths and head group charge magnitude (but different signs) can interact and reorient interfacial water molecules diffe...
Source: Chemphyschem - September 7, 2023 Category: Chemistry Authors: Thao Nguyen Foad Raji Cuong Nguyen Ngoc Nguyen Anh V Nguyen Source Type: research
Effect of canagliflozin in non-diabetic obese patients with albuminuria: A randomized, double-blind, placebo-controlled trial
CONCLUSION: Canagliflozin 100 mg daily was well tolerated but did not significantly reduce UACR in non-diabetic obese patients with microalbuminuria. However, a significant temporary decline in eGFR might reflect a subtle reduction in glomerular hyperfiltration.PMID:37675488 | DOI:10.5414/CN111143
Source: Clinical Nephrology - September 7, 2023 Category: Urology & Nephrology Authors: Primploy Greeviroj Pongpratch Puapatanakul Jeerath Phannajit Kullaya Takkavatakarn Wonngarm Kittanamongkolchai Patchaya Boonchaya-Anant Pisut Katavetin Kearkiat Praditpornsilpa Somchai Eiam-Ong Paweena Susantitaphong Source Type: research
GABA < sub > B1 < /sub > receptor knockdown in prefrontal cortex induces behavioral aberrations associated with autism spectrum disorder in mice
Brain Res Bull. 2023 Sep 7;202:110755. doi: 10.1016/j.brainresbull.2023.110755. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is a set of heterogeneous neurodevelopmental disorders, characterized by social interaction deficit, stereotyped or repetitive behaviors. Apart from these core symptoms, a great number of individuals with ASD exhibit higher levels of anxiety and memory deficits. Previous studies demonstrate pronounced decrease of γ-aminobutyric acid B1 receptor (GABAB1R) protein level of frontal lobe in both ASD patients and animal models. The aim of the present study was to determine the role of GAB...
Source: Brain Research Bulletin - September 7, 2023 Category: Neurology Authors: Xiaona Wang Zhengqin Zhao Jisheng Guo Daoqi Mei Yongtao Duan Yaodong Zhang Lingshan Gou Source Type: research
