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Nutrition: Sodium
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Peripheral temperature dysregulation associated with functionally altered Na < sub > V < /sub > 1.8 channels
Pflugers Arch. 2023 Sep 11. doi: 10.1007/s00424-023-02856-2. Online ahead of print.ABSTRACTThe voltage-gated sodium channel NaV1.8 is prominently expressed in the soma and axons of small-caliber sensory neurons, and pathogenic variants of the corresponding gene SCN10A are associated with peripheral pain and autonomic dysfunction. While most disease-associated SCN10A variants confer gain-of-function properties to NaV1.8, resulting in hyperexcitability of sensory neurons, a few affect afferent excitability through a loss-of-function mechanism. Using whole-exome sequencing, we here identify a rare heterozygous SCN10A missense...
Source: Pflugers Archiv : European Journal of Physiology - September 11, 2023 Category: Physiology Authors: Simon Loose Annette Lischka Samuel Kuehs Carla Nau Stefan H Heinemann Ingo Kurth Enrico Leipold Source Type: research
Inhibition of carbonic anhydrase using aspirin is a novel method to block schistosomiasis infection of the parasitic trematode, Schistosoma mansoni, in the intermediate snail host, Biomphalaria glabrata
In this study, we investigated the role of CA inhibition in B. glabrata snails exposed to S. mansoni miracidia. We analyzed the expression of the B. glabrata CA encoding transcript in juvenile susceptible and resistant snails, with and without exposure to S. mansoni. Our results showed that the expression of the CA mRNA encoding transcript was upregulated during early and prolonged infection in susceptible snails (BBO2), but not in the resistant BS-90 stock. Notably, sodium salicylate, a form of aspirin, inhibited the expression of CA, post-exposure, to the parasite. Increasing research between parasites and cancer has sho...
Source: Experimental Parasitology - September 11, 2023 Category: Parasitology Authors: Simone Parn Gabriela Lewis Matty Knight Source Type: research
Current advances and emerging trends in sustainable polyhydroxyalkanoate modification from organic waste streams for material applications
This study focuses on the development of sustainable, efficient, and cutting-edge methods, such as advanced bioprocess engineering, novel catalysts, and advances in materials science. Chemical techniques, such as epoxidation, oxidation, and esterification, have been employed for PHA functionalization, while enzymatic and microbial methods have indicated promise. PHB/polylactic acid blends with cellulose fibers showed improved tensile strength by 24.45-32.08 % and decreased water vapor and oxygen transmission rates while PHB/Polycaprolactone blends with a 1:1 ratio demonstrated an elongation at break four to six times highe...
Source: International Journal of Biological Macromolecules - September 11, 2023 Category: Biochemistry Authors: Nausheen Jaffur Gopalakrishnan Kumar Pratima Jeetah Seeram Ramakrishna Shashi Kant Bhatia Source Type: research
Inhibition of carbonic anhydrase using aspirin is a novel method to block schistosomiasis infection of the parasitic trematode, Schistosoma mansoni, in the intermediate snail host, Biomphalaria glabrata
In this study, we investigated the role of CA inhibition in B. glabrata snails exposed to S. mansoni miracidia. We analyzed the expression of the B. glabrata CA encoding transcript in juvenile susceptible and resistant snails, with and without exposure to S. mansoni. Our results showed that the expression of the CA mRNA encoding transcript was upregulated during early and prolonged infection in susceptible snails (BBO2), but not in the resistant BS-90 stock. Notably, sodium salicylate, a form of aspirin, inhibited the expression of CA, post-exposure, to the parasite. Increasing research between parasites and cancer has sho...
Source: Experimental Parasitology - September 11, 2023 Category: Parasitology Authors: Simone Parn Gabriela Lewis Matty Knight Source Type: research
Sodium-Glucose Cotransporter 2 Inhibitors and Pathological Myocardial Hypertrophy
Curr Drug Targets. 2023 Sep 7. doi: 10.2174/1389450124666230907115831. Online ahead of print.ABSTRACTSodium-glucose cotransporter 2 (SGLT2) inhibitors are a new type of oral hypoglycemic drugs that exert a hypoglycemic effect by blocking the reabsorption of glucose in the proximal renal tubules, thus promoting the excretion of glucose from urine. Their hypoglycemic effect is not dependent on insulin. Increasing data shows that SGLT2 inhibitors improve cardiovascular outcomes in patients with type 2 diabetes. Previous studies have demonstrated that SGLT2 inhibitors can reduce pathological myocardial hypertrophy with or with...
Source: Current Drug Targets - September 11, 2023 Category: Drugs & Pharmacology Authors: Zhicheng Gao Jiaqi Bao Yilan Hu Junjie Tu Lifang Ye Lihong Wang Source Type: research
National monitoring of iodine, sodium, and vitamin D status in toddlers and women of childbearing age - results and lessons learned from a pilot study in Norway
CONCLUSION: Lessons learned from the pilot study will be used to design a national monitoring program for toddlers and women of childbearing age in Norway. The results indicate that 2-year-old children and women of childbearing age in Norway may have inadequate iodine intakes at the group level, while for vitamin D, most of the mothers had adequate status.PMID:37691743 | PMC:PMC10492227 | DOI:10.29219/fnr.v67.9088
Source: Food and Nutrition Research - September 11, 2023 Category: Nutrition Authors: Synne Groufh-Jacobsen Marianne Hope Abel Anne Lise Brants æter Maria Andersson Haakon E Meyer Sigrun Henjum Source Type: research
Sodium Trifluoroacetate mediated Copper-Catalyzed < em > aza < /em > -Michael addition of < em > α,β < /em > -unsaturated olefins with aromatic amines
We present a sodium trifluoroacetate (CF3CO2Na) mediated copper-catalyzed aza-Michael addition of aromatic amines with activated olefins under mild, aqueous reaction conditions. This simplistic protocol employs a copper catalyst (10 mol%) and water as solvent. This transformation occurs precisely with aromatic substituted amines containing both electron-donating (EDG) and electron-withdrawing (EWG) groups. A broad range of substrates were tested under the optimized conditions, which are producing good to moderate yields.PMID:37694227 | PMC:PMC10486139 | DOI:10.1016/j.tetlet.2023.154520
Source: Tetrahedron Letters - September 11, 2023 Category: Chemistry Authors: S Erfan Masaeli Mohsen Teimouri Bhupendra Adhikari Mahshid Attarroshan James W Akin Selvam Raju Sean L Stokes Joseph P Emerson Source Type: research
National monitoring of iodine, sodium, and vitamin D status in toddlers and women of childbearing age - results and lessons learned from a pilot study in Norway
CONCLUSION: Lessons learned from the pilot study will be used to design a national monitoring program for toddlers and women of childbearing age in Norway. The results indicate that 2-year-old children and women of childbearing age in Norway may have inadequate iodine intakes at the group level, while for vitamin D, most of the mothers had adequate status.PMID:37691743 | PMC:PMC10492227 | DOI:10.29219/fnr.v67.9088
Source: Food and Nutrition Research - September 11, 2023 Category: Nutrition Authors: Synne Groufh-Jacobsen Marianne Hope Abel Anne Lise Brants æter Maria Andersson Haakon E Meyer Sigrun Henjum Source Type: research
Inhibition of carbonic anhydrase using aspirin is a novel method to block schistosomiasis infection of the parasitic trematode, Schistosoma mansoni, in the intermediate snail host, Biomphalaria glabrata
In this study, we investigated the role of CA inhibition in B. glabrata snails exposed to S. mansoni miracidia. We analyzed the expression of the B. glabrata CA encoding transcript in juvenile susceptible and resistant snails, with and without exposure to S. mansoni. Our results showed that the expression of the CA mRNA encoding transcript was upregulated during early and prolonged infection in susceptible snails (BBO2), but not in the resistant BS-90 stock. Notably, sodium salicylate, a form of aspirin, inhibited the expression of CA, post-exposure, to the parasite. Increasing research between parasites and cancer has sho...
Source: Experimental Parasitology - September 11, 2023 Category: Parasitology Authors: Simone Parn Gabriela Lewis Matty Knight Source Type: research
Enhanced Sodium Ion Batteries' Performance: Optimal Strategies on Electrolytes for Different Carbon-based Anodes
ChemSusChem. 2023 Sep 11:e202300876. doi: 10.1002/cssc.202300876. Online ahead of print.ABSTRACTCarbon-based materials have emerged as promising anodes for sodium-ion batteries (SIBs) due to the advantages of cost-effectiveness and renewability, whereas the unsatisfactory performance has hampered the commercialization of SIBs. During the past decades, tremendous efforts have been put to enhance the electrochemical performance of SIBs from the perspective of improving the compatibility of electrolytes and electrodes. Hence, a systematic summary of the strategies for tuning electrolytes between hard carbon, graphite, and oth...
Source: ChemSusChem - September 11, 2023 Category: Chemistry Authors: Lu Liu Goh Zhi Ling Loh Kah Hoe Jerome Liew Shahid Bashir Ramesh Kasi Ramesh T Subramaniam Source Type: research
Short-term Effects of Cadmium Exposure on Blood Pressure and Vascular Function in Wistar Rats
This study aimed to investigate the pressoric and vascular effects of a 7-day exposure to CdCl2 in Wistar rats. The rats were divided in control group (Ct), which received tap water, and the Cd group, which received a 100 mg/L CdCl2 solution via drinking water for 7 days. We analyzed body weight, plasma Cadmium concentration, systolic blood pressure (SBP), and vascular responses. Despite relatively low plasma Cadmium concentration, the Cd group exhibited elevated SBP and increased contractile response to phenylephrine. Endothelium removal and NOS inhibition increased contractions in both groups. In the Cd group's aorta, we...
Source: Biological Trace Element Research - September 11, 2023 Category: Biology Authors: Karoline Alves Rossi Camila Cruz Pereira Almenara Rakel Passos Sim ões Lorraine Christiny Costa Sepulchro Mulher Maiara Krause Maria Tereza W D Carneiro Alessandra Sim ão Padilha Source Type: research
National monitoring of iodine, sodium, and vitamin D status in toddlers and women of childbearing age - results and lessons learned from a pilot study in Norway
CONCLUSION: Lessons learned from the pilot study will be used to design a national monitoring program for toddlers and women of childbearing age in Norway. The results indicate that 2-year-old children and women of childbearing age in Norway may have inadequate iodine intakes at the group level, while for vitamin D, most of the mothers had adequate status.PMID:37691743 | PMC:PMC10492227 | DOI:10.29219/fnr.v67.9088
Source: Food and Nutrition Research - September 11, 2023 Category: Nutrition Authors: Synne Groufh-Jacobsen Marianne Hope Abel Anne Lise Brants æter Maria Andersson Haakon E Meyer Sigrun Henjum Source Type: research
Sodium Trifluoroacetate mediated Copper-Catalyzed < em > aza < /em > -Michael addition of < em > α,β < /em > -unsaturated olefins with aromatic amines
We present a sodium trifluoroacetate (CF3CO2Na) mediated copper-catalyzed aza-Michael addition of aromatic amines with activated olefins under mild, aqueous reaction conditions. This simplistic protocol employs a copper catalyst (10 mol%) and water as solvent. This transformation occurs precisely with aromatic substituted amines containing both electron-donating (EDG) and electron-withdrawing (EWG) groups. A broad range of substrates were tested under the optimized conditions, which are producing good to moderate yields.PMID:37694227 | PMC:PMC10486139 | DOI:10.1016/j.tetlet.2023.154520
Source: Tetrahedron Letters - September 11, 2023 Category: Chemistry Authors: S Erfan Masaeli Mohsen Teimouri Bhupendra Adhikari Mahshid Attarroshan James W Akin Selvam Raju Sean L Stokes Joseph P Emerson Source Type: research
Sodium-Glucose Cotransporter 2 Inhibitors and Pathological Myocardial Hypertrophy
Curr Drug Targets. 2023 Sep 7. doi: 10.2174/1389450124666230907115831. Online ahead of print.ABSTRACTSodium-glucose cotransporter 2 (SGLT2) inhibitors are a new type of oral hypoglycemic drugs that exert a hypoglycemic effect by blocking the reabsorption of glucose in the proximal renal tubules, thus promoting the excretion of glucose from urine. Their hypoglycemic effect is not dependent on insulin. Increasing data shows that SGLT2 inhibitors improve cardiovascular outcomes in patients with type 2 diabetes. Previous studies have demonstrated that SGLT2 inhibitors can reduce pathological myocardial hypertrophy with or with...
Source: Current Drug Targets - September 11, 2023 Category: Drugs & Pharmacology Authors: Zhicheng Gao Jiaqi Bao Yilan Hu Junjie Tu Lifang Ye Lihong Wang Source Type: research
