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Therapy: Radiation Therapy
Nutrition: Sodium
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Total 27 results found since Jan 2013.
Protective effects of activated vitamin D receptor on radiation-induced intestinal injury
In this study, we investigated the effect of the expression and regulation of VDR on the protection of RIII, and the radiosensitivity in vitro experiments, and explored the initial mechanism of VDR in regulating radiosensitivity of IEC. As a result, we found that the expression of VDR in intestinal tissues and cells in mice can be induced by ionizing radiation. VDR agonists are able to prolong the average survival time of mice after radiation and reduce the radiation-induced intestinal injury. For lack of vitamin D, the radiosensitivity of intestinal epithelial cells in mice increased, which can be reduced by VDR activatio...
Source: Molecular Medicine - December 29, 2022 Category: Molecular Biology Authors: Yuhan Lin Penglin Xia Fangyu Cao Cheng Zhang Yajie Yang Haitao Jiang Haishan Lin Hu Liu Ruling Liu Xiaodong Liu Jianming Cai Source Type: research
One step synthesis of < sup > 10 < /sup > B-enriched < sup > 10 < /sup > BPO < sub > 4 < /sub > nanoparticles for effective boron neutron capture therapeutic treatment of recurrent head-and-neck tumor
In this study, 10B-riched (98.5% 10B) boron phosphate nanoparticles (10BPO4 NPs) of ∼100 nm in size were prepared in a single step using a unique microwave arcing method. The 10B-enriched 10BPO4 NPs were surface-modified with anti-EGFR antibody to endow the targeting ability toward H&N cancer cells. In in-vivo xenograft mice model, a large amount (∼63 μg 10B/g cancer cells) of 10B atoms could be effectively accumulated at the H&N tumor sites using 10BPO4 NPs as BNCT reagents. In in-vitro neutron irradiation experiments, 72% cell deaths were observed from anti-EGFR-10BPO4 NPs-treated H&N cancer cells, which...
Source: Biomaterials - October 27, 2022 Category: Materials Science Authors: Naresh Kuthala Munusamy Shanmugam Chao-Ling Yao Chi-Shiun Chiang Kuo Chu Hwang Source Type: research
Actual practice of Kochi oxydol radiation therapy for unresectable carcinomas by intra-tumoral administration of hydrogen peroxide as a radiosensitizer
Mol Clin Oncol. 2022 Mar;16(3):68. doi: 10.3892/mco.2022.2501. Epub 2022 Jan 21.ABSTRACTKochi oxydol radiation therapy for unresectable carcinomas (KORTUC) is a novel cancer treatment method developed in Japan. KORTUC targets resistance factors in cancer therapy, such as low-oxygen environments and excessive antioxidant enzymes. This may enhance the effects of conventional treatments. The present study reports the experience of the Nagasaki Prefecture Shimabara Hospital in using KORTUC treatment for a series of 210 patients between January 2010 and June 2019. When this radiosensitizer, a mixture of a dilute hydrogen peroxi...
Source: Clinical Genitourinary Cancer - February 14, 2022 Category: Cancer & Oncology Authors: Shiro Obata Yutaka Ishimaru Shigenori Miyagi Mika Nakatake Akira Kuroiwa Yoshiaki Ohta Tsunehiko Kan Shinya Kanegae Yohta Inoue Rhoichi Nishizato Kohki Miyazaki Source Type: research
Evaluation of the efficacy of the anti-ulcer oral mucosal protective agent RADoralex ® in the prevention and treatment of radiation-induced oral mucosal reactions induced during treatment of nasopharyngeal carcinoma
Cancer Biol Ther. 2022 Jan 6:1-7. doi: 10.1080/15384047.2021.2013704. Online ahead of print.ABSTRACTThe aim of this study was to evaluate the efficacy and safety of antiulcer oral mucosal protectant-RADoralex® in the prevention and treatment of radiation-induced oral mucosal reactions elicited during intensity-modulated radiation therapy (IMRT). for locally advanced nasopharyngeal carcinoma (NPC). A total of 90 patients with locally advanced NPC who developed post-treatment grade 1 oral mucositis were selected for this study. They were randomly assigned to the experimental group (n = 44) treated by mouth rinsing with the ...
Source: Cancer Biology and Therapy - January 6, 2022 Category: Cancer & Oncology Authors: Jun Yin Jirui Xie Jiawei Lin Chengyin Weng Shun Lu Peng Xu Shuo Zhang Cheng Luo Yecai Huang Lu Li Jinyi Lang Mei Feng Source Type: research
The Preventive Effects of Boron-Based Gel on Radiation Dermatitis in Patients Being Treated for Breast Cancer: A Phase III Randomized, Double-Blind, Placebo-Controlled Clinical Trial
CONCLUSION: The boron-based gel has a significant preventive effect on several categories of RD which might be used by clinicians in breast cancer.PMID:34979503 | DOI:10.1159/000520363
Source: Cancer Control - January 3, 2022 Category: Cancer & Oncology Authors: Fikrettin Sahin Mohammad Bagher Pirouzpanah Hossein Bijanpour Mohammad Mohammadzadeh Reza Eghdam Zamiri Amir Ghasemi Jangjoo Behnam Nasiri Hojjatollah Saboori Ay şegül Doğan Selami Demirci Erhan Ay şan Ahmet Çağrı Büke Ali Reza Naseri Seyed Kazem Source Type: research
New enzyme-targeting radiosensitizer (KORTUC II) treatment for locally advanced or recurrent breast cancer
Mol Clin Oncol. 2021 Nov;15(5):241. doi: 10.3892/mco.2021.2388. Epub 2021 Sep 24.ABSTRACTKochi oxydol radiation therapy for unresectable carcinomas II (KORTUC II) is currently the most widely used radiosensitizer in Japan. This sensitizer is a solution consisting of 0.83% sodium hyaluronate and 0.5% hydrogen peroxide. The mixture is injected intratumorally just before radiation therapy (RT) several times. KORTUC II has the effect of neutralizing antioxidant enzymes, while increasing the oxygen tension into the tumor tissue, and achieves marked local effects without notable adverse events. The present report describes cases...
Source: Clinical Breast Cancer - October 15, 2021 Category: Cancer & Oncology Authors: Taiju Shimbo Mio Nakata Hiroto Yoshioka Chikara Sato Akihiro Hori Kosei Kimura Mitsuhiko Iwamoto Ken Yoshida Yasuo Uesugi Hironori Akiyama Keiji Nihei Source Type: research
