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Total 512 results found since Jan 2013.
Intratumoral Bacteria as Mediators of Cancer Immunotherapy Response
Cancer Res. 2023 Sep 15;83(18):2985-2986. doi: 10.1158/0008-5472.CAN-23-1857.ABSTRACTMultiple lines of evidence spanning from animal models to human clinical trials indicate that the microbiome influences cancer immunotherapy response. Whereas initial studies focused exclusively on the gastrointestinal (gut) microbiota-tumor axis, more recent studies have examined the possibility that bacteria located within tumor cells or within the tumor microenvironment mediate cancer treatment response. Strikingly, this phenomenon has been demonstrated in cancers that arise in anatomic locations that are traditionally thought to be dev...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Karen S Sfanos Source Type: research
Postbiotic as Novel Alternative Agent or Adjuvant for the Common Antibiotic Utilized in the Food Industry
CONCLUSION: Postbiotic constituents may be a new approach for utilization in the pharmaceutical and food sectors for developing therapeutic treatments. Further metabolomics investigations are required to describe novel postbiotics and clinical trials are also required to define the sufficient dose and optimum administration frequency of postbiotics.PMID:37702234 | DOI:10.2174/1389201025666230912123849
Source: Current Pharmaceutical Biotechnology - September 13, 2023 Category: Biotechnology Authors: Sama Sepordeh Amir Mohammad Jafari Sara Bazzaz Amin Abbasi Ramin Aslani Sousan Houshmandi Aziz Homayouni Rad Source Type: research
Ootheca mantidis mitigates renal fibrosis in mice by the suppression of apoptosis via increasing the gut microbe Akkermansia muciniphila and modulating glutamine metabolism
In this study, we demonstrated the dose-dependent attenuation of RIF by Ootheca mantidis (SPX), a commonly prescribed TCM for CKD, in a mouse model of unilateral ureteral obstruction (UUO). RNA-sequencing analysis suggested that SPX treatment prominently downregulated apoptosis and inflammation-associated pathways, thereby inhibiting the fibrogenic signaling in the kidney. We further found that transplantation of fecal microbiota from SPX-treated mice conferred protection against renal injury and fibrosis through suppressing apoptosis in UUO mice, indicating that SPX ameliorated RIF via remodeling the gut microbiota and re...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 7, 2023 Category: Drugs & Pharmacology Authors: Jue Wang Xiaozhen Guo Ziyuan Zou Minjun Yu Xueling Li Hualing Xu Yiping Chen Tingying Jiao Kanglong Wang Yuandi Ma Jie Jiang Xinyu Liang Jiawen Wang Cen Xie Yifei Zhong Source Type: research
Transformation of colitis and colorectal cancer: a tale of gut microbiota
Crit Rev Microbiol. 2023 Sep 6:1-10. doi: 10.1080/1040841X.2023.2254388. Online ahead of print.ABSTRACTIntestinal inflammation modifies host physiology to promote the occurrence of colorectal cancer (CRC), as seen in colitis-associated CRC. Gut microbiota is crucial in cancer progression, primarily by inducing intestinal chronic inflammatory microenvironment, leading to DNA damage, chromosomal mutation, and alterations in specific metabolite production. Therefore, there is an increasing interest in microbiota-based prevention and treatment strategies, such as probiotics, prebiotics, microbiota-derived metabolites, and feca...
Source: Critical Reviews in Microbiology - September 6, 2023 Category: Microbiology Authors: Kai Xia Renyuan Gao Lin Li Xiaocai Wu Tianqi Wu Yu Ruan Lu Yin Chunqiu Chen Source Type: research
Age-dependent modulation of gut microbiome in response to tumor immunomodulation
In this study, we sequentially treated young mice (~8 weeks) and old mice (>18 months) with bilateral melanoma using FUS and calreticulin nanoparticles (CRT-NP) to enhance immunogenic cell death. The combination of CRT-NP and FUS (CFUS) demonstrated greater efficacy in inducing regression of treated and untreated tumors in young mice compared to old mice. The diminished effectiveness in older mice was associated with significant differences in gut microbiome composition, characterized by alterations in bacterial species and splenic immune cells. Specifically, young mice exposed to CFUS exhibited higher abundance of Bact...
Source: Experimental Gerontology - August 12, 2023 Category: Geriatrics Authors: Akansha Singh Harshini Ashar Ashish Ranjan Source Type: research
Unraveling mechanistic insights into the role of microbiome in neurogenic hypertension: A comprehensive review
Pathol Res Pract. 2023 Aug 6;249:154740. doi: 10.1016/j.prp.2023.154740. Online ahead of print.ABSTRACTNeurogenic hypertension, a complex and multifactorial cardiovascular disorder, is known to be influenced by various genetic, environmental, and lifestyle factors. In recent years, there has been growing interest in the role of the gut microbiome in hypertension pathogenesis. The bidirectional communication between the gut microbiota and the central nervous system, known as the microbiota-gut-brain axis, has emerged as a crucial mechanism through which the gut microbiota exerts its influence on neuroinflammation, immune re...
Source: Pathology, Research and Practice - August 11, 2023 Category: Pathology Authors: Yusang Dai Zheng Shen Lusine G Khachatryan Diana E Vadiyan Sajad Karampoor Rasoul Mirzaei Source Type: research
