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Therapy: Cancer Therapy
Nutrition: Iron
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Total 244 results found since Jan 2013.
Functionalized manganese iron oxide nanoparticles: a dual potential magneto-chemotherapeutic cargo in a 3D breast cancer model
Nanoscale. 2023 Sep 19. doi: 10.1039/d3nr02816j. Online ahead of print.ABSTRACTLocalized heat generation from manganese iron oxide nanoparticles (MIONPs) conjugated with chemotherapeutics under the exposure of an alternating magnetic field (magneto-chemotherapy) can revolutionize targeted breast cancer therapy. On the other hand, the lack of precise control of local temperature and adequate MIONP distribution in laboratory settings using the conventional two-dimensional (2D) cellular models has limited its further translation in tumor sites. Our current study explored advanced 3D in vitro tumor models as a promising altern...
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Satish S Phalake Sandeep B Somvanshi Syed A M Tofail Nanasaheb D Thorat Vishwajeet M Khot Source Type: research
Iron oxide nanoparticles induce ferroptosis via the autophagic pathway by synergistic bundling with paclitaxel
Mol Med Rep. 2023 Oct;28(4):198. doi: 10.3892/mmr.2023.13085. Epub 2023 Sep 8.ABSTRACTIn recent years, inhibiting tumor cell activity by triggering cell ferroptosis has become a research hotspot. The development of generic targeted nanotherapeutics might bring new ideas for non‑invasive applications. Currently, the potential mechanism underlying the universal application of paclitaxel (PTX)‑loaded iron oxide nanoparticles (IONP@PTX) to different types of tumors is unclear. The present study aimed to prepare IONP@PTX for targeted cancer therapy and further explore the potential mechanisms underlying the inhibitory effec...
Source: Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Qi Nie Wenqing Chen Tianmei Zhang Shangrong Ye Zhongyu Ren Peng Zhang Jian Wen Source Type: research
NIR-II photoacoustic imaging-guided synergistic cancer therapy with a tumor-targeting copper selenide-iron manganese layered double hydroxide nanocomplex
Chem. Commun., 2023, Advance Article DOI: 10.1039/D3CC03080F, CommunicationYanting Yang, Shulong Wang, Shengqiang Hu, Yanni Luo, Zongyi He, Shulin Zhao A novel biodegradable copper selenide-iron manganese layered double hydroxide nanocomplex was developed. This nanocomplex was used for NIR-II photoacoustic imaging-guided synergistic cancer therapy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - September 4, 2023 Category: Chemistry Authors: Yanting Yang Source Type: research
In situ and dynamic SERS monitoring of glutathione levels during cellular ferroptosis metabolism
Anal Bioanal Chem. 2023 Aug 30. doi: 10.1007/s00216-023-04909-y. Online ahead of print.ABSTRACTFerroptosis is a non-apoptotic cell death regulated by iron-dependent lipid peroxidation. Glutathione (GSH), a key antioxidant against oxidative damage, is involved in one of the most important metabolic pathways of ferroptosis. Herein, an excellent plasmonic nanoprobe was developed for highly sensitive, in situ, dynamic real-time monitoring of intracellular GSH levels during ferroptosis. A nanoprobe was prepared by functionalizing gold nanoparticles (AuNPs) with the probe molecule crystal violet (CV). The fluctuation in the SERS...
Source: Analytical and Bioanalytical Chemistry - August 29, 2023 Category: Chemistry Authors: Lixing Xu Xing Du Tianqing Liu Dan Sun Source Type: research
NIR-II photoacoustic imaging-guided synergistic cancer therapy with tumor-targeting copper selenide-iron manganese layered double hydroxide nanocomplex
Chem. Commun., 2023, Accepted Manuscript DOI: 10.1039/D3CC03080F, CommunicationYanting Yang, Shulong Wang, Shengqiang Hu, Yan-Ni Luo, Zongyi He, Shulin Zhao A novel biodegradable layered double hydroxide-copper selenide nanocomplex was prepared by anchoring copper selenide on the manganese iron layered double hydroxide nanosheets. This nanocomplex can specifically release CuSe, Mn2+ and... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - August 24, 2023 Category: Chemistry Authors: Yanting Yang Source Type: research
Copper-instigated modulatory cell mortality mechanisms and progress in oncological treatment investigations
Front Immunol. 2023 Aug 2;14:1236063. doi: 10.3389/fimmu.2023.1236063. eCollection 2023.ABSTRACTCopper, a transition metal, serves as an essential co-factor in numerous enzymatic active sites and constitutes a vital trace element in the human body, participating in crucial life-sustaining activities such as energy metabolism, antioxidation, coagulation, neurotransmitter synthesis, iron metabolism, and tetramer deposition. Maintaining the equilibrium of copper ions within biological systems is of paramount importance in the prevention of atherosclerosis and associated cardiovascular diseases. Copper induces cellular demise ...
Source: Atherosclerosis - August 21, 2023 Category: Cardiology Authors: Lei Gao Anqi Zhang Source Type: research
Polyporus umbellatus polysaccharide iron-based nanocomposite for synergistic M1 polarization of TAMs and combinational anti-breast cancer therapy
Int J Biol Macromol. 2023 Aug 14:126323. doi: 10.1016/j.ijbiomac.2023.126323. Online ahead of print.ABSTRACTM1 polarization of tumor-associated macrophages (TAMs) is a promising approach to breaking through therapeutic barriers imposed by the immunosuppressive tumor microenvironment (TME). As a clinically-used immunopotentiator for cancer patients after chemotherapies; however, the immunomodulatory mechanism and potential of polyporus polysaccharide (PPS) remains unclear. Here, we present mannose-decorated PPS-loaded superparamagnetic iron-based nanocomposites (Man/PPS-SPIONs) for synergistic M1 polarization of TAMs and co...
Source: International Journal of Biological Macromolecules - August 16, 2023 Category: Biochemistry Authors: Tingting Liu Tao Han Congyan Liu Chang Ge Xi Jiang Yuping Liu Fei Kong Xiangyu Su Jiachen Shi Wenting Su Xiaoqi Li Yan Chen Huangqin Zhang Qiuling Ma Ding Qu Source Type: research
Heterogeneous-Driven Glutathione Oxidation: Defining the Catalytic Role of Chalcopyrite Nanoparticles
J Phys Chem C Nanomater Interfaces. 2023 Jul 12;127(29):14146-14154. doi: 10.1021/acs.jpcc.3c00987. eCollection 2023 Jul 27.ABSTRACTTransition-metal nanocatalysis represents a novel alternative currently experiencing flourishing progress to tackle the tumor microenvironment (TME) in cancer therapy. These nanomaterials aim at attacking tumor cells using the intrinsic selectivity of inorganic catalysts. In addition, special attention to tune and control the release of these transition metals is also required. Understanding the chemical reactions behind the catalytic action of the transition-metal nanocatalysts and preventing...
Source: Cancer Control - August 2, 2023 Category: Cancer & Oncology Authors: Leticia Sanchez-Uriel Javier Bonet-Aleta Alfonso Ibarra Jose L Hueso Source Type: research
Dissecting the Role of SMYD2 and Its Inhibitor (LLY-507) in the Treatment of Chemically Induced Non-Small Cell Lung Cancer (NSCLC) by Using Fe < sub > 3 < /sub > O < sub > 4 < /sub > Nanoparticles Drug Delivery System
In this study, we loaded LLY-507, a potent inhibitor of SMYD2, a methyltransferase enzyme, on iron oxide nanoparticles (IONPs). The prepared nanoparticles were characterized by microscopic analysis, loading efficiency, and drug release studies. Microscopic examination revealed an average grain size of 44 nm. The in vitro effect of LLY-507-IONPs, LLY-507, and IONPs was determined by MTT analysis (A549 cells) and hemolysis studies. IONPs have almost negative hemolytic activity in blood. The cell viability assay revealed IC50 values of both LLY-507 alone and LLY-507-loaded IONPs against A549; the lower value of the drug loade...
Source: Cancer Control - July 29, 2023 Category: Cancer & Oncology Authors: Aasma Munawwar Amna Sajjad Azhar Rasul Mehran Sattar Farhat Jabeen Source Type: research
Recent advancements in the targeted delivery of etoposide nanomedicine for cancer therapy: A comprehensive review
This article summarizes substantial progress made in the development of ETO nanomedicine for the treatment of cancer. It discusses various organic and inorganic nanostructures used to load or affix ETOs, such as lipids, liposomes, polymeric nanoparticles (NPs), dendrimers, micelles, gold NPs, iron oxide NPs, and silica NPs. In addition, it evaluates the structural properties of these nanostructures, such as their size, zeta potential, encapsulation efficiency, and drug release mechanism, as well as their in vitro or in vivo performance. The article also emphasizes the co-delivery of ETO with other medications or agents to ...
Source: European Journal of Medicinal Chemistry - July 27, 2023 Category: Chemistry Authors: Sonia Fathi-Karkan Rabia Arshad Abbas Rahdar Aghdas Ramezani Razieh Behzadmehr Suresh Ghotekar Sadanand Pandey Source Type: research
