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News at a glance: Long Covid defined, x-rayed atoms, and a tally of deep-sea biodiversity
WATER POLICY U.S. wetland protections curtailed In a decision that reduces federal protections for wetlands, the U.S. Supreme Court last week narrowed the definition of marshy areas covered by the Clean Water Act. A five-justice majority led by Justice Samuel Alito ruled the law applies only to wetlands that have a “continuous surface connection” to nearby regulated waters, rejecting an approach currently used by federal agencies that wetlands require only a “significant nexus.” Four justices led by Justice Brett Kavanaugh argued the new standard is too narrow, ignores the law’s intent to protect w...
Source: Science of Aging Knowledge Environment - June 1, 2023 Category: Geriatrics Source Type: research

Understanding the health and wellbeing challenges of the food banking system: A qualitative study of food bank users, providers and referrers in London
Publication date: Available online 16 May 2018 Source:Social Science & Medicine Author(s): C. Thompson, D. Smith, S. Cummins In the UK, food poverty has been associated with conditions such as obesity, malnutrition, hypertension, iron deficiency, and impaired liver function. Food banks, the primary response to food poverty on the ground, typically rely on community referral and distribution systems that involve health and social care professionals and local authority public health teams. The perspectives of these key stakeholders remain underexplored. This paper reports on a qualitative study of the health and wel...
Source: Social Science and Medicine - May 16, 2018 Category: Psychiatry & Psychology Source Type: research

Loss-of-Function in SMAD4 Might Not Be Critical for Human Natural Killer Cell Responsiveness to TGF- β
This study was carried out in accordance with approval of the Melbourne Health and Walter and Eliza Hall Institute of Medical Research's Human Research Ethics Committee (approval number: 2013.081). All subjects gave written informed consent for participation and publication. Results and Discussion TGF-β signaling in NK cells is associated with: phosphorylation in SMAD2 and 3, inhibition of IL-15-induced metabolism/proliferation, simultaneous downregulation of CD44, CD49e, and Eomes, and upregulation of CD16 and CD49a expression (7, 10). SMAD family member 4 (SMAD4) belongs to the SMAD family of transcript...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research

How Much Breast Milk Does a Lactating Woman Make?
Discussion Each person needs to eat the right about of healthy foods to maintain a healthy body. This varies based on gender, age, activity, healthy problems, or health status. Healthy women who are moderately active and not pregnant or lactating need about 1800-2000 calories/day. Pregnant women are advised to keep the calories the same in the first trimester (about 1800 calories/day), increase ~200-300 (about 2200 calories/day)in the second trimester, and then increase ~300-400 in third trimester (about 2400 calories/day). The increase in calories should be met by a normally balanced and varied diet. When pregnant or br...
Source: PediatricEducation.org - May 11, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Second International Guidelines for the Diagnosis and Management of Hereditary Hemorrhagic Telangiectasia.
ksen C, Dupuis-Girod S, Foy P, Geisthoff U, Gossage JR, Hammill A, Heimdal K, Henderson K, Iyer VN, Kjeldsen AD, Komiyama M, Korenblatt K, McDonald J, McMahon J, McWilliams J, Meek ME, Mei-Zahav M, Olitsky S, Palmer S, Pantalone R, Piccirillo JF, Plahn B, Porteous MEM, Post MC, Radovanovic I, Rochon PJ, Rodriguez-Lopez J, Sabba C, Serra M, Shovlin C, Sprecher D, White AJ, Winship I, Zarrabeitia R Abstract DESCRIPTION: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease with an estimated prevalence of 1 in 5000 that is characterized by the presence of vascular malformations (VMs). These res...
Source: Annals of Internal Medicine - September 7, 2020 Category: Internal Medicine Authors: Faughnan ME, Mager JJ, Hetts SW, Palda VA, Lang-Robertson K, Buscarini E, Deslandres E, Kasthuri RS, Lausman A, Poetker D, Ratjen F, Chesnutt MS, Clancy M, Whitehead KJ, Al-Samkari H, Chakinala M, Conrad M, Cortes D, Crocione C, Darling J, de Gussem E, De Tags: Ann Intern Med Source Type: research

Review and update of the importance of micronutrients in pediatric age: a holistic view
Nutr Hosp. 2022 Jul 28. doi: 10.20960/nh.04305. Online ahead of print.ABSTRACTInternational health institutions have implemented protocols and nutritional health policies in the promotion of health and brain development. However, these policies do not usually extend to preschool age, being a stage of important changes and very dynamic development. Therefore the objective of this work is to carry out a review of the information available about nutritional needs throughout the process of human development, emphasizing the main micronutrients, their role in development and what the evidence tells us about the effects of it la...
Source: Nutricion Hospitalaria - August 30, 2022 Category: Nutrition Authors: Inmaculada Ferreres Gim énez Mar ía Gloria Pueyo Alamán M ª Gloria Pueyo Alamán M ª José Alonso Osorio Source Type: research

Red Blood Cell Enzyme Disorders
Mature red blood cells are reliant on the glycolytic pathway for energy production and the hexose monophosphate shunt for cell protection from oxidative insults. The most common red blood cell enzyme disorders are characterized by hemolysis but with wide clinical variability. Glucose-6-phosphate dehydrogenase deficiency is the most common red cell enzyme disorder worldwide. Frequent clinical presentations include neonatal jaundice and episodic hemolysis after exposure to oxidative stress. Symptoms of pyruvate kinase deficiency and other glycolytic enzyme disorders include neonatal jaundice, chronic hemolytic anemia, gallst...
Source: Pediatric Clinics of North America - May 24, 2018 Category: Pediatrics Authors: Rachael F. Grace, Bertil Glader Source Type: research

Trends in Anemia, Iron Therapy and Transfusion in Pediatric Inflammatory Bowel Disease
Discussion:Iron deficiency anemia is highly prevalent among pediatric patients with IBD admitted to U.S. children's hospitals. The upward trend during this 5 year study period may potentially be due to increased recognition of this complication. Regarding management, we identified an increase in the use of IV iron for the treatment of IDA over time, and a decrease in admitted patients receiving transfusions. Further research is needed to further optimize detection of iron deficiency in pediatric IBD patients as well as evaluate the best approach for management of this common complication.DisclosuresNo relevant conflicts of...
Source: Blood - November 21, 2018 Category: Hematology Authors: Jacobson-Kelly, A. E., Stanek, J. R., Powers, J. M., O'Brien, S. H. Tags: 901. Health Services Research-Non-Malignant Conditions: Poster II Source Type: research

Nutritional Status, Nutrient Intake, and Food Diversity Among Children With Sickle Cell Anemia
This study aimed to investigate the association between nutritional status, nutrient intake, and food diversity in children with SCA. A descriptive cross-sectional study was conducted on 74 children with SCA, between 24 and 71 months of age. Anthropometric measurements, food and nutrients consumption were determined. The prevalence of low weight, stunting, and overweight/obesity were 16.2%, 35.1%, and 16.2%, respectively. Mean folic acid intake was low (49.05%±51.22%), whereas the intakes of protein (426.71%±171.93%), retinol (292.97%±403.88%), phosphorus (204.55%±151.35%), magnesium (233.02%±151.14%), iron (250.76%±...
Source: Journal of Pediatric Hematology Oncology - March 22, 2019 Category: Hematology Tags: Online Articles: Original Articles Source Type: research