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Total 126 results found since Jan 2013.

Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy-Induced Necrosis
Cancer Res. 2023 Jul 31:OF1-OF16. doi: 10.1158/0008-5472.CAN-23-0157. Online ahead of print.ABSTRACTSeveral emerging therapies kill cancer cells primarily by inducing necrosis. As necrosis activates immune cells, potentially, uncovering the molecular drivers of anticancer therapy-induced necrosis could reveal approaches for enhancing immunotherapy efficacy. To identify necrosis-associated genes, we performed a genome-wide CRISPR-Cas9 screen with negative selection against necrosis-inducing preclinical agents BHPI and conducted follow-on experiments with ErSO. The screen identified transient receptor potential melastatin me...
Source: Cell Research - July 31, 2023 Category: Cytology Authors: Santanu Ghosh Rachel Yang Darjan Duraki Junyao Zhu Ji Eun Kim Musarrat Jabeen Chengjian Mao Xinyi Dai Mara R Livezey Matthew W Boudreau Ben H Park Erik R Nelson Paul J Hergenrother David J Shapiro Source Type: research

Non-interfacial self-assembly of synthetic protocells
CONCLUSION: This synthetic protocell fabricated by the NISA method simulates the occurrence and development process of primitive life, which has great potential application value in mRNA vaccine, cancer immunotherapy, and drug delivery.PMID:37400932 | DOI:10.1186/s40824-023-00402-w
Source: Cell Research - July 3, 2023 Category: Cytology Authors: Xiaolin Xu Wencai Guan Xiaolei Yu Guoxiong Xu Chenglong Wang Source Type: research

Traditional Treatment Approaches and Role of Immunotherapy in Lung Malignancy and Mesothelioma
Cancer Treat Res. 2023;185:79-89. doi: 10.1007/978-3-031-27156-4_5.ABSTRACTThere is no denying that many revolutions took place in the fight against cancer during the last decades. However, cancers have always managed to find new ways to challenge humankinds. Variable genomic epidemiology, socio-economic differences and limitations of widespread screening are the major concerns in cancer diagnosis and early treatment. A multidisciplinary approach is essentially to manage a cancer patient efficiently. Thoracic malignancies including lung cancers and pleural mesothelioma are accountable for little more than 11.6% of the glob...
Source: Cell Research - June 12, 2023 Category: Cytology Authors: Mirza Tasnia Tamanna Christopher Egbune Source Type: research

A Novel Glycolysis-Related Long Noncoding RNA Signature for Predicting Overall Survival in Gastric Cancer
Conclusion: Our study shows that the signature can predict the prognosis of GC and may provide new insights into immunotherapeutic strategies.PMID:36419649 | PMC:PMC9676246 | DOI:10.3389/pore.2022.1610643
Source: Pathology Oncology Research - November 24, 2022 Category: Pathology Authors: Jianmin Zeng Man Li Kefan Dai Bingyu Zuo Jianhui Guo Lu Zang Source Type: research

Disulfiram loaded calcium phosphate nanoparticles for enhanced cancer immunotherapy
Biomaterials. 2022 Oct 27;291:121880. doi: 10.1016/j.biomaterials.2022.121880. Online ahead of print.ABSTRACTConsidering the huge cost and long test periods required for new drug development, repurposing drugs that have already been applied in the clinic as new cancer treatment candidates represents an attractive alternative. Disulfiram (DSF) was originally used to treat alcoholism and has proven to have anticancer effects with the coadministration of copper ions (Cu2+). However, the limited water-solubility of DSF and systemic toxicity induced by exogenous Cu2+ hinder its practical application. Herein, we constructed pH-r...
Source: Biomaterials - November 5, 2022 Category: Materials Science Authors: Qiaofeng Li Yu Chao Bo Liu Zhisheng Xiao Zhijuan Yang Yuzhe Wu Zhuang Liu Source Type: research

Cancers, Vol. 14, Pages 5363: Electroporation in Head-and-Neck Cancer: An Innovative Approach with Immunotherapy and Nanotechnology Combination
i Marco Benazzo Squamous cell carcinoma is the most common malignancy that arises in the head-and-neck district. Traditional treatment could be insufficient in case of recurrent and/or metastatic cancers; for this reason, more selective and enhanced treatments are in evaluation in preclinical and clinical trials to increase in situ concentration of chemotherapy drugs promoting a selectively antineoplastic activity. Among all cancer treatment types (i.e., surgery, chemotherapy, radiotherapy), electroporation (EP) has emerged as a safe, less invasive, and effective approach for cancer treatment. Reversible EP, using an...
Source: Cancers - October 31, 2022 Category: Cancer & Oncology Authors: Silvia Pisani Giulia Bertino Adriele Prina-Mello Laura Deborah Locati Simone Mauramati Ida Genta Rossella Dorati Bice Conti Marco Benazzo Tags: Review Source Type: research

Fight Aging! Newsletter, September 26th 2022
This study examined the dose-response association between daily step count and intensity and incidence of all-cause dementia among adults in the UK. This was a UK Biobank prospective population-based cohort study (February 2013 to December 2015) with 6.9 years of follow-up (data analysis conducted May 2022). A total of 78,430 of 103,684 eligible adults aged 40 to 79 years with valid wrist accelerometer data were included. Registry-based dementia was ascertained through October 2021. We found no minimal threshold for the beneficial association of step counts with incident dementia. Our findings suggest that approxima...
Source: Fight Aging! - September 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Neuronally expressed PDL1, not PD1, suppresses acute nociception
Brain Behav Immun. 2022 Sep 8:S0889-1591(22)00376-2. doi: 10.1016/j.bbi.2022.09.001. Online ahead of print.ABSTRACTPDL1 is a protein that induces immunosuppression by binding to PD1 expressed on immune cells. In line with historical studies, we found that membrane-bound PD1 expression was largely restricted to immune cells; PD1 was not detectable at either the mRNA or protein level in peripheral neurons using single neuron qPCR, immunolabeling and flow cytometry. However, we observed widespread expression of PDL1 in both sensory and sympathetic neurons that could have important implications for patients receiving immunothe...
Source: Brain, Behavior, and Immunity - September 11, 2022 Category: Neurology Authors: Kimberly A Meerschaert Brian S Edwards Ariel Y Epouhe Bahiyyah Jefferson Robert Friedman Olivia L Babyok Jamie K Moy Faith Kehinde Chang Liu Creg J Workman Dario A A Vignali Kathryn M Albers H Richard Koerber Michael S Gold Brian M Davis Nicole N Scheff J Source Type: research