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New concentration-response functions for seven morbidity endpoints associated with short-term PM < sub > 2.5 < /sub > exposure and their implications for health impact assessment
DISCUSSION: The higher estimates produced by the nonlinear CRFs indicates the possibility of a large underestimation in current assessments of the morbidity impacts attributable to air pollution. Further studies should be pursued to better constrain the CRFs studied here, and to better characterize the causal relationship between exposures to PM2.5 and morbidity outcomes.PMID:37659174 | DOI:10.1016/j.envint.2023.108122
Source: Environment International - September 2, 2023 Category: Environmental Health Authors: Muye Ru Drew Shindell Joseph V Spadaro Jean-Fran çois Lamarque Ariyani Challapalli Fabian Wagner Gregor Kiesewetter Source Type: research
Ligand-mediated Targeted Drug Delivery Approaches against Hepatocellular Carcinoma
Curr Cancer Drug Targets. 2023;23(11):879-888. doi: 10.2174/1568009623666230503094346.ABSTRACTOne of the most important health problems in the world today is cancer. The World Health Organization (WHO) reported that it results in 8.9 million deaths annually. Malignant tumours and unregulated cell proliferation are features of malignant neoplasms, which can also invade nearby body regions. Hepatocellular carcinoma is the third most prevalent cause of cancer-related death worldwide and the fifth most common kind of cancer, according to a recent analysis. Patients with liver disease as well as chronic hepatitis B and C are mo...
Source: Current Cancer Drug Targets - September 1, 2023 Category: Cancer & Oncology Authors: Amrita Singh Sudhanshu Mishra Saurabh Sharma Smriti Ojha Sunil Yagnik Sudhi Pandey Source Type: research
The long road to schistosomiasis elimination in Zanzibar: A systematic review covering 100 years of research, interventions and control milestones
Adv Parasitol. 2023;122:71-191. doi: 10.1016/bs.apar.2023.06.001. Epub 2023 Jul 17.ABSTRACTZanzibar is among the few places in sub-Saharan Africa where interruption of Schistosoma transmission seems an achievable goal. Our systematic review identifies and discusses milestones in schistosomiasis research, control and elimination efforts in Zanzibar over the past 100 years. The search in online databases, libraries, and the World Health Organization Archives revealed 153 records published between May 1928 and August 2022. The content of records was summarised to highlight the pivotal work leading towards urogenital schistoso...
Source: Advances in Parasitology - September 1, 2023 Category: Parasitology Authors: Lydia Trippler Stefanie Knopp Sophie Welsche Bonnie L Webster J Russell Stothard Lynsey Blair Fiona Allan Shaali Makame Ame Saleh Juma Fatma Kabole Said Mohammed Ali David Rollinson Tom Pennance Source Type: research
Ligand-mediated Targeted Drug Delivery Approaches against Hepatocellular Carcinoma
Curr Cancer Drug Targets. 2023;23(11):879-888. doi: 10.2174/1568009623666230503094346.ABSTRACTOne of the most important health problems in the world today is cancer. The World Health Organization (WHO) reported that it results in 8.9 million deaths annually. Malignant tumours and unregulated cell proliferation are features of malignant neoplasms, which can also invade nearby body regions. Hepatocellular carcinoma is the third most prevalent cause of cancer-related death worldwide and the fifth most common kind of cancer, according to a recent analysis. Patients with liver disease as well as chronic hepatitis B and C are mo...
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Amrita Singh Sudhanshu Mishra Saurabh Sharma Smriti Ojha Sunil Yagnik Sudhi Pandey Source Type: research
Comparison of home-based palliative care delivered by community health workers versus usual care: research protocol for a pilot randomized controlled trial
DISCUSSION: Pal-Care is a RCT funded by the NCI to explore utilization of CHWs to deliver a home-based palliative care intervention built upon the WHO Palliative Care toolkit (PCT), as compared to a usual care control group. The long-term goal of this research is to develop an effective and sustainable model for delivering home-based palliative care for cancer patients in underserved areas.TRIAL REGISTRATION (TRN): ClinicalTrials.gov ID# NCT04972630.PMID:37658397 | DOI:10.1186/s12904-023-01235-z
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Suparna Qanungo Kathleen B Cartmell Martina Mueller Melissa Butcher Saswati Sarkar Tyler-Gail Carlson Mohan Madisetti Gaurav Kumar Source Type: research
The long road to schistosomiasis elimination in Zanzibar: A systematic review covering 100 years of research, interventions and control milestones
Adv Parasitol. 2023;122:71-191. doi: 10.1016/bs.apar.2023.06.001. Epub 2023 Jul 17.ABSTRACTZanzibar is among the few places in sub-Saharan Africa where interruption of Schistosoma transmission seems an achievable goal. Our systematic review identifies and discusses milestones in schistosomiasis research, control and elimination efforts in Zanzibar over the past 100 years. The search in online databases, libraries, and the World Health Organization Archives revealed 153 records published between May 1928 and August 2022. The content of records was summarised to highlight the pivotal work leading towards urogenital schistoso...
Source: Advances in Parasitology - September 1, 2023 Category: Parasitology Authors: Lydia Trippler Stefanie Knopp Sophie Welsche Bonnie L Webster J Russell Stothard Lynsey Blair Fiona Allan Shaali Makame Ame Saleh Juma Fatma Kabole Said Mohammed Ali David Rollinson Tom Pennance Source Type: research
Determinants of Cervical Cancer Screening Among Women Aged 30-49 Years Old in Four African Countries: A Cross-Sectional Secondary Data Analysis
CONCLUSION: The prevalence of cervical cancer screening in Kenya, Cameroon, Nambia, and Zimbabwe was low as compared to World Health Organization (WHO) recommendations. Age, residence, work status, smoking status, women's age at first birth, condom use, husbands having work, wealth status, and health insurance were the identified determinants of cervical cancer screening. Programme and policy interventions could address younger, rural residence women, poor wealth status women, women without work, and those who never use health insurance for the uptake of cervical cancer screening.PMID:37656980 | DOI:10.1177/10732748231195681
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Melsew Setegn Alie Yilkal Negesse Mengistu Ayenew Source Type: research
Factors that impact on recruitment to vaccine trials in the context of a pandemic or epidemic: a qualitative evidence synthesis
CONCLUSIONS: This review identifies many of the factors that influence a person's decision to take part in a vaccine trial, and these reflect findings from reviews that examine trials more broadly. However, we also recognise some factors that become more important in connection with a vaccine trial in the context of a pandemic or epidemic. These factors include the potential stigma of taking part, the possible adverse effects of a vaccine, the added motivation for helping society, the role of community leaders in trial dissemination, and the level of trust placed in governments and companies developing vaccines. These spec...
Source: Cochrane Database of Systematic Reviews - September 1, 2023 Category: General Medicine Authors: Pauline Meskell Linda M Biesty Maura Dowling Kevin Roche Elaine Meehan Claire Glenton Declan Devane Sasha Shepperd Andrew Booth Rebecca Cox Xin Hui S Chan Catherine Houghton Source Type: research
Relationship Between Gastrointestinal Symptoms in Autism Spectrum Disorder and Parent Stress, Anxiety, Depression, Quality of Life and Social Support
J Autism Dev Disord. 2023 Sep 1. doi: 10.1007/s10803-023-06110-7. Online ahead of print.ABSTRACTGastrointestinal (GI) symptoms are a common comorbidity in children and adolescents with autism spectrum disorder (ASD). Little is known about the impact that GI symptoms have on parental well-being. Parents of 409 children and adolescents with ASD completed the GI Symptoms Inventory, Parenting Stress Index-Short Form, World Health Organization Quality of Life Abbreviated Version, Hospital Anxiety and Depression Scale, and the Multidimensional Scale of Perceived Social Support. High levels of stress were demonstrated by parents ...
Source: Journal of Autism and Developmental Disorders - September 1, 2023 Category: Psychiatry Authors: Arlene Mannion Geraldine Leader Source Type: research
Ligand-mediated Targeted Drug Delivery Approaches against Hepatocellular Carcinoma
Curr Cancer Drug Targets. 2023;23(11):879-888. doi: 10.2174/1568009623666230503094346.ABSTRACTOne of the most important health problems in the world today is cancer. The World Health Organization (WHO) reported that it results in 8.9 million deaths annually. Malignant tumours and unregulated cell proliferation are features of malignant neoplasms, which can also invade nearby body regions. Hepatocellular carcinoma is the third most prevalent cause of cancer-related death worldwide and the fifth most common kind of cancer, according to a recent analysis. Patients with liver disease as well as chronic hepatitis B and C are mo...
Source: Current Cancer Drug Targets - September 1, 2023 Category: Cancer & Oncology Authors: Amrita Singh Sudhanshu Mishra Saurabh Sharma Smriti Ojha Sunil Yagnik Sudhi Pandey Source Type: research
Factors that impact on recruitment to vaccine trials in the context of a pandemic or epidemic: a qualitative evidence synthesis
CONCLUSIONS: This review identifies many of the factors that influence a person's decision to take part in a vaccine trial, and these reflect findings from reviews that examine trials more broadly. However, we also recognise some factors that become more important in connection with a vaccine trial in the context of a pandemic or epidemic. These factors include the potential stigma of taking part, the possible adverse effects of a vaccine, the added motivation for helping society, the role of community leaders in trial dissemination, and the level of trust placed in governments and companies developing vaccines. These spec...
Source: Cochrane Database of Systematic Reviews - September 1, 2023 Category: General Medicine Authors: Pauline Meskell Linda M Biesty Maura Dowling Kevin Roche Elaine Meehan Claire Glenton Declan Devane Sasha Shepperd Andrew Booth Rebecca Cox Xin Hui S Chan Catherine Houghton Source Type: research
The long road to schistosomiasis elimination in Zanzibar: A systematic review covering 100 years of research, interventions and control milestones
Adv Parasitol. 2023;122:71-191. doi: 10.1016/bs.apar.2023.06.001. Epub 2023 Jul 17.ABSTRACTZanzibar is among the few places in sub-Saharan Africa where interruption of Schistosoma transmission seems an achievable goal. Our systematic review identifies and discusses milestones in schistosomiasis research, control and elimination efforts in Zanzibar over the past 100 years. The search in online databases, libraries, and the World Health Organization Archives revealed 153 records published between May 1928 and August 2022. The content of records was summarised to highlight the pivotal work leading towards urogenital schistoso...
Source: Advances in Parasitology - September 1, 2023 Category: Parasitology Authors: Lydia Trippler Stefanie Knopp Sophie Welsche Bonnie L Webster J Russell Stothard Lynsey Blair Fiona Allan Shaali Makame Ame Saleh Juma Fatma Kabole Said Mohammed Ali David Rollinson Tom Pennance Source Type: research
