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Total 340 results found since Jan 2013.

Vitamin A biomarkers were associated with AGP and CRP over the course of a human norovirus challenge infection
Br J Nutr. 2023 Sep 11:1-19. doi: 10.1017/S0007114523002076. Online ahead of print.ABSTRACTRetinol binding protein (RBP) is used as a proxy for retinol in population-based assessments of vitamin A deficiency (VAD) for cost-effectiveness and feasibility. When the cutoff of <0.7 mol/L for retinol is applied to RBP to define VAD, an equivalence of the two biomarkers is assumed. Evidence suggests that the relationship between retinol and RBP is not 1:1, particularly in populations with a high burden of infection or inflammation. The goal of this analysis was to longitudinally evaluate the retinol:RBP ratio over one month of...
Source: The British Journal of Nutrition - September 11, 2023 Category: Nutrition Authors: Courtney P Victor Juan S Leon Anne M Williams Source Type: research

Associations between protein to non-protein ratio and intakes of other dietary components in a cohort aged 65-75 years: the Nutrition for Healthy Living Study
CONCLUSIONS: Higher P:NP was associated with lower intakes of energy, saturated fat, free sugar and discretionary. Our study revealed substantial nutritional inadequacy in this group of higher socioeconomic individuals aged 65-75 years.PMID:37565467 | DOI:10.1017/S1368980023001726
Source: Public Health Nutrition - August 11, 2023 Category: International Medicine & Public Health Authors: Rebecca Luong Rosilene V Ribeiro Vasant Hirani Stephen J Simpson David G Le Couteur David Raubenheimer Alison K Gosby Source Type: research

Fight Aging! Newsletter, June 12th 2023
In this study, we investigated the effect of NXP032 on neurovascular stabilization through the changes of PECAM-1, PDGFR-β, ZO-1, laminin, and glial cells involved in maintaining the integrity of the blood-brain barrier (BBB) in aged mice. NXP032 was orally administered daily for 8 weeks. Compared to young mice and NXP032-treated mice, 20-month-old mice displayed cognitive impairments in Y-maze and passive avoidance tests. NXP032 treatment contributed to reducing the BBB damage by attenuating the fragmentation of microvessels and reducing PDGFR-β, ZO-1, and laminin expression, thereby mitigating astrocytes and microglia ...
Source: Fight Aging! - June 11, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Utilization of Marine Seaweeds as a Promising Defense Against COVID-19: a Mini-review
Mar Biotechnol (NY). 2023 May 27. doi: 10.1007/s10126-023-10214-7. Online ahead of print.ABSTRACTCOVID-19 is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which mainly affects the respiratory system. It has been declared as a "pandemic" in March 2020 by the World Health Organization due to the high spreading rate. SARS-CoV-2 binds with the angiotensin-converting enzyme 2 (ACE2) receptors on the cell surface which leads to the downregulation of ACE2 and upregulation of angiotensin-converting enzyme (ACE) receptors. The elevated level of cytokines and ACE receptors leads to the ...
Source: Marine Biotechnology - May 27, 2023 Category: Biotechnology Authors: M D T L Gunathilaka Source Type: research

Exploring the internal exposome of seminal plasma with semen quality and live birth: A Pilot Study
The objective of this pilot study is to test whether untargeted metabolomics is capable of discriminating reproductive outcomes and understand associations between the internal exposome of seminal plasma and the reproductive outcomes of semen quality and live birth among ten participants undergoing assisted reproductive technology (ART) in Springfield, MA. We hypothesize that seminal plasma offers a novel biological matrix by which untargeted metabolomics is able to discern male reproductive status and predict reproductive success. The internal exposome data was acquired using UHPLC-HR-MS on randomized seminal plasma sampl...
Source: Reproductive Biology - April 25, 2023 Category: Reproduction Medicine Authors: Emily Houle YuanYuan Li Madison Schroder Susan L McRitchie Tayyab Rahil Cynthia K Sites Susan Jenkins Sumner J Richard Pilsner Source Type: research

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of deep vein thrombosis
CONCLUSIONS: The current review suggests that DOACs may be superior to conventional therapy in terms of safety (major bleeding), and are probably equivalent in terms of efficacy. There is probably little or no difference between DOACs and conventional anticoagulation in the prevention of recurrent VTE, recurrent DVT, pulmonary embolism and all-cause mortality. DOACs reduced the rate of major bleeding compared to conventional anticoagulation. The certainty of evidence was moderate or high.PMID:37058421 | DOI:10.1002/14651858.CD010956.pub3
Source: Cochrane Database of Systematic Reviews - April 14, 2023 Category: General Medicine Authors: Xiaoqin Wang Yanfang Ma Xu Hui Meixuan Li Jing Li Jinhui Tian Qi Wang Peijing Yan Jianfeng Li Ping Xie Kehu Yang Liang Yao Source Type: research

Oral direct thrombin inhibitors or oral factor Xa inhibitors  versus conventional anticoagulants for the treatment of pulmonary embolism
CONCLUSIONS: Available evidence shows there is probably little or no difference between DOACs and conventional anticoagulation in the prevention of recurrent PE, recurrent VTE, DVT, all-cause mortality, and major bleeding. The certainty of evidence was moderate or low. Future large clinical trials are required to identify if individual drugs differ in effectiveness and bleeding risk, and to explore effect differences in subgroups, including people with cancer and obesity.PMID:37057837 | DOI:10.1002/14651858.CD010957.pub3
Source: Cochrane Database of Systematic Reviews - April 14, 2023 Category: General Medicine Authors: Meixuan Li Jing Li Xiaoqin Wang Xu Hui Qi Wang Shitong Xie Peijing Yan Jinhui Tian Jianfeng Li Ping Xie Kehu Yang Liang Yao Source Type: research

Association between hemoglobin and elevation among school-aged children: a verification of proposed adjustments
CONCLUSION: Results confirm that current recommended Hb adjustments for elevation may need updating, and anemia prevalence in SAC may be higher than currently estimated. Findings will inform the WHO reexamination of global guidelines on the use of Hb adjustments for anemia assessment and may result in improved identification and treatment of anemia.PMID:37059418 | DOI:10.1016/j.ajcnut.2023.04.014
Source: Am J Clin Nutr - April 14, 2023 Category: Nutrition Authors: Florence A Kanu Maria Elena D Jefferds Anne M Williams O Yaw Addo Parminder S Suchdev Andrea J Sharma Source Type: research