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Analysis of google trends and search results for ophthalmic symptoms of monkeypox
ConclusionSearch interest in monkeypox ophthalmic symptoms corresponds with geographic and temporal trends, i.e., timing and location of the first reported non-endemic cases and WHO announcement. Although ophthalmic symptoms are not as widely searched currently, inclusion in public health messaging is key for diagnosis, appropriate management, and reduction of further transmission.
Source: International Ophthalmology - April 18, 2023 Category: Opthalmology Source Type: research

Reweaving the Tapestry: a Supertree of Birds
Conclusions The supertree is the first published species-level supertree of birds. It is also the first comprehensive phylogeny of birds to include fossils; both recently extinct and Mesozoic taxa, which are of vital importance for analyses requiring an understanding of the deep evolutionary history of birds. It is not intended to be the final word in avian systematics nor is it intended to be used as a basis for re-evaluating avian taxonomy. It does, however, provide a platform upon which further research can be based and will hopefully provide a useful resource for researchers studying avian macroevolution, conservation,...
Source: PLOS Currents Tree of Life - June 9, 2014 Category: Genetics & Stem Cells Authors: katiedavis Source Type: research

Irving Fisher ' s Search for Stable Money: What We Can Learn
ConclusionIn thinking about monetary alternatives, there is no better place to start then a review of Irving Fisher ’s work, especiallyThe Purchasing Power of Money.   His insights can guide all those interested in improving the current government fiat money regime and in avoiding the mistakes of the past.  The Fed, in particular, ought to listen to what Fisher had to say about sound money—that is, money of stable purchasing power.  There is no perfect mone tary system, but one needs to understand what a “good system” would look like in order to move in the right direction.  A deep knowledge of monetary theory,...
Source: Cato-at-liberty - January 17, 2019 Category: American Health Authors: James A. Dorn Source Type: blogs

ConforMIS plunges on lowered outlook, search for new CEO
Shares of ConforMIS (NSDQ:CFMS) closed down nearly -8% yesterday and plunged another -40% in after-hours trading, after the medical device company lowered its outlook for the rest of the year and said it’s looking for a new CEO to replace founder Dr. Phillip Lang. Losses widened 5.4% to -$15.0 million, or -37 per share, on sales of $20.3 million for the 3 months ended March 31 for Bedford, Mass.-based ConforMIS, for top-line growth of 37.8%. Analysts on Wall Street were looking for losses of -36 on sales of $20.2 million. “First quarter of 2016 showed strong revenue growth with product revenue up 36% year-over-yea...
Source: Mass Device - May 13, 2016 Category: Medical Equipment Authors: Brad Perriello Tags: MassDevice Earnings Roundup Orthopedics Wall Street Beat ConforMIS Inc. Personnel Moves Source Type: news

WellCare’s CEO search and other takeaways from its 2Q discussion
The CEO search at WellCare Health Plans Inc. is taking longer than originally expected, but another executive announcement could be coming in a month or two. That’s one of the key take-aways from a conference call between analysts leaders of WellCare (NYSE: WCG), one of the largest public companies in Tampa Bay. The call largely focused on the managed care company’s second quarter 2014 loss and its dramatically reduced earnings guidance for 2014. Here are a few tidbits that stood out: When…
Source: bizjournals.com Health Care:Physician Practices headlines - July 25, 2014 Category: American Health Authors: Margie Manning Source Type: research

Rite Aid Losses Mount As CEO Search Identifies Candidates
Rite Aid losses hit nearly $100 million in the company ’s first quarter as the struggling retailer faces reimbursement pressures amid a search for a new CEO.
Source: Forbes.com Healthcare News - June 26, 2019 Category: Pharmaceuticals Authors: Bruce Japsen, Contributor Source Type: news

Patients with hepatitis C lost to follow-up: ethical-legal aspects and search results.
CONCLUSION: a large number of patients with hepatitis C are lost to follow-up. Searching for and contacting these patients is legally and ethically viable. PMID: 32579001 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - June 25, 2020 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

Fight Aging! Newsletter, January 21st 2019
In this study, scientists screened cells from old animals to identify any RBPs that change upon aging. The screening showed that one particular protein, Pumilio2 (PUM2), was highly induced in old animals. PUM2 binds mRNA molecules containing specific recognition sites. Upon its binding, PUM2 represses the translation of the target mRNAs into proteins. Using a systems genetics approach, the researchers then identified a new mRNA target that PUM2 binds. The mRNA encodes for a protein called Mitochondrial Fission Factor (MFF), and is a pivotal regulator of mitochondrial fission - a process by which mitochondria break u...
Source: Fight Aging! - January 20, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, June 19th 2017
This study is the first to show that downregulation of PAPP-A expression in adult mice can significantly extend life span. Importantly, this beneficial longevity phenotype is distinct from the dwarfism of long-lived PAPP-A KO, Ames dwarf, Snell dwarf and growth hormone receptor (GHR) KO mice with germ-line mutations. Thus, downregulation of PAPP-A expression joins other treatment regimens, such as resveratrol, rapamycin and dietary restriction, which can extend life span when started in mice as adults. In a recent study, inducible knockdown of the GHR in young adult female mice increased maximal, but not median, lif...
Source: Fight Aging! - June 18, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, January 29th 2018
In conclusion, the present study demonstrated that TIGIT is a prominent negative immune regulator involved in immunosenescence. This novel finding is highly significant, as targeting TIGIT might be an effective strategy to improve the immune response and decrease age-related comorbidities. Delivery of Extracellular Vesicles as a Potential Basis for Therapies https://www.fightaging.org/archives/2018/01/delivery-of-extracellular-vesicles-as-a-potential-basis-for-therapies/ Here I'll point out a readable open access review paper on the potential use of extracellular vesicles as a basis for therapy: harveste...
Source: Fight Aging! - January 28, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, November 8th 2021
In conclusion, in less common and visible cardiovascular diseases, it is crucial to recognize substantial progress and achievement, given that penetration of such information into clinical practice and the patient community can be inconsistent. Diseases such as hypertrophic cardiomyopathy, pulmonary arterial hypertension, and ATTR cardiac amyloidosis, once linked to a uniformly adverse prognosis, are now associated with the opportunity for patients to experience satisfactory quality of life and extended longevity. VitaDAO, a Novel Approach to Crowdfunding Life Science Research https://www.fightaging.org/archive...
Source: Fight Aging! - November 7, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Identifying and Describing the Impact of Cyclone, Storm and Flood Related Disasters on Treatment Management, Care and Exacerbations of Non-communicable Diseases and the Implications for Public Health
Conclusion Cyclone, flood and storm related disasters impact on treatment management and overall care for people with NCDs. This results in an increased risk of exacerbation of illness or even death. The interruption may be caused by a range of factors, such as damaged transport routes, reduced health services, loss of power and evacuations. The health impact varies according to the NCD. For people with chronic respiratory diseases, a disaster increases the risk of acute exacerbation. Meanwhile, for people with cancer, cardiovascular diseases and diabetes there is an increased risk of their illness exacerbating, which can ...
Source: PLOS Currents Disasters - September 28, 2015 Category: Global & Universal Authors: jc164421 Source Type: research

Turning PBM " Arbitrage " On Its Head: Bypassing Insurance to Save
The word of the day is " arbitrage " . Officially, Merriam-Webster defines the English language word " arbitrage " this way: " The nearly simultaneous purchase and sale of securities or foreign exchange in different markets in order to profit from price discrepancies " . However, arbitrage does not exclusively apply to securities sold on Wall Street. The term has also been adopted by the Pharmacy Benefit Manager ( " PBM " ) industry. But PBM ' s are not Wall Street investment banks. And that ' s something we all need to realize.The PBM Accountability Project 2021 report " Understanding the Evolving Business Model...
Source: Scott's Web Log - July 25, 2022 Category: Endocrinology Tags: 2022 arbitrage coupon-generating websites apps coupons Medicare PBM Source Type: blogs

Fight Aging! Newsletter, August 8th 2016
In conclusion, spermidine inhibits lipid accumulation and necrotic core formation through stimulation of cholesterol efflux, albeit without changing plaque size or cellular composition. These effects, which are driven by autophagy in VSMCs, support the general idea that autophagy induction is potentially useful to prevent vascular disease. Intestinal Autophagy Important in Calorie Restriction and Longevity in Nematodes https://www.fightaging.org/archives/2016/08/intestinal-autophagy-important-in-calorie-restriction-and-longevity-in-nematodes/ Based on the evidence accumulated from many years of studies of ...
Source: Fight Aging! - August 7, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Diagnosis, Phenotype, and Molecular Genetics of Congenital Analbuminemia
Conclusion Figure 4 shows that the 27 different molecular defects within the ALB so far reported to cause CAA are located in ten different exons (1, 3, 4, 5, 7, 8, 9, 10, 11, and 12) and in seven different introns (1, 2, 3, 6, 10, 11, and 12) (The Albumin Website, 2018; Caridi et al., 2019). Variations in the last two coding exons (13 and 14) would probably cause the presence of a circulating C-terminal variant of the protein and not CAA. The first twelve exons of ALB, with the exception of the two shortest, exons 2 and 6, were reported to contain at least one molecular defect resulting in CAA (The Albumin Website, 2018; ...
Source: Frontiers in Genetics - April 16, 2019 Category: Genetics & Stem Cells Source Type: research