• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Pretreatment of Mouse Neural Stem Cells with Carbon Monoxide-Releasing Molecule-2 Interferes with NF-κB p65 Signaling and Suppresses Iron Overload-Induced Apoptosis.
Abstract Neural stem cell (NSC) transplantation is a promising approach to repair the damaged brain after hemorrhagic stroke; however, it is largely limited by the poor survival of donor cells. Breakdown products of the hematoma and subsequent iron overload contribute to the impairment of survival of neural cells. There is little information regarding the mechanism involved in the death of grafted cells. Furthermore, therapeutic research targeted to improving the survival of grafted neural stem cells (NSCs) is strikingly lacking. Here, we showed that iron overload induced apoptosis of C17.2 cells, a cell line orig...
Source: Cellular and Molecular Neurobiology - March 10, 2016 Category: Cytology Authors: Xie Z, Han P, Cui Z, Wang B, Zhong Z, Sun Y, Yang G, Sun Q, Bian L Tags: Cell Mol Neurobiol Source Type: research

Induction of neurorestoration from endogenous stem cells.
Abstract Neural stem cells persist in the subventricular zone lining the ventricle of the adult brain. The resident stem/progenitor cells can be stimulated in vivo by neurotrophic factors, hematopoietic growth factors, magnetic stimulation and/or physical exercise. In both animals and humans, the differentiation and survival of neurons arising from the subventricular zone may be also regulated by the trophic factors. The presence of stem/progenitor cells in the adult brain and the fact that the production of new neurons occurs at specific sites suggest a possibility for the treatment of otherwise incurable neurolo...
Source: Cell Transplantation - January 18, 2016 Category: Cytology Authors: Yu JH, Seo JH, Lee JY, Lee MY, Cho SR Tags: Cell Transplant Source Type: research

DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome.
Abstract The integrity of the nuclear lamina has emerged as an important factor in the maintenance of genome stability. In particular, mutations in the LMNA gene, encoding A-type lamins (lamin A/C), alter nuclear morphology and function, and cause genomic instability. LMNA gene mutations are associated with a variety of degenerative diseases and devastating premature aging syndromes such as Hutchinson-Gilford Progeria Syndrome (HGPS) and Restrictive Dermopathy (RD). HGPS is a severe laminopathy, with patients dying in their teens from myocardial infarction or stroke. HGPS patient-derived cells exhibit nuclear shap...
Source: Current Opinion in Cell Biology - June 12, 2015 Category: Cytology Authors: Gonzalo S, Kreienkamp R Tags: Curr Opin Cell Biol Source Type: research

Cord blood for brain injury
Publication date: Available online 19 March 2015 Source:Cytotherapy Author(s): Jessica M. Sun , Joanne Kurtzberg Recovery from neurological injuries is typically incomplete and often results in significant and permanent disabilities. Currently, most available therapies are limited to supportive or palliative measures, aimed at managing the symptoms of the condition. Because restorative therapies targeting the underlying cause of most neurological diseases do not exist, cell therapies targeting anti-inflammatory, neuroprotective and regenerative potential hold great promise. Cord blood (CB) cells can induce repair through...
Source: Cytotherapy - March 19, 2015 Category: Cytology Source Type: research

Paracrine Factors Secreted by MSCs Promote Astrocyte Survival Associated with GFAP Downregulation After Ischemic Stroke Via p38 MAPK and JNK
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - March 6, 2015 Category: Cytology Authors: Weiyi Huang, Bingke Lv, Huijun Zeng, Dandan Shi, Yi Liu, Fanfan Chen, Feng Li, Xinghui Liu, Rong Zhu, Lei Yu, Xiaodan Jiang Tags: Original Research Article Source Type: research

Intranasal Delivery of Bone Marrow Mesenchymal Stem Cells Improved Neurovascular Regeneration and Rescued Neuropsychiatric Deficits after Neonatal Stroke in Rats.
Abstract Neonatal stroke is a major cause of mortality and long-term morbidity in infants and children. Currently very limited therapeutic strategies are available to protect the developing brain against ischemic damage and promote brain repairs for pediatric patients. Moreover, children who experienced neonatal stroke often have developmental social behavior problems. Cellular therapy using bone marrow mesenchymal stem cells (BMSCs) has emerged as a regenerative therapy after stroke. In the present investigation, neonatal stroke of postnatal day 7 (P7) rat pups was treated with non-invasive and brain specific int...
Source: Cell Transplantation - February 2, 2015 Category: Cytology Authors: Wei ZZ, Gu X, Ferdinand A, Lee JH, Ji X, Ji XM, Yu SP, Wei L Tags: Cell Transplant Source Type: research

The potential therapeutic applications of olfactory ensheathing cells in regenerative medicine.
Abstract Olfactory ensheathing cells (OECs) are unique glia cells restricted to the primary olfactory system including the olfactory mucosa, olfactory nerve, and the outer nerve layer of the olfactory bulb. OECs guide growing olfactory axons from the neurons of the nasal cavity olfactory mucosa to the olfactory bulb to connect both the peripheral nervous system (PNS) and central nervous system (CNS). Based on these specialized abilities of OECs, transplantation of OECs to injury sites has been widely investigated for their potential therapeutic applications in neural repair in different injuries. In this article, ...
Source: Cell Transplantation - May 17, 2014 Category: Cytology Authors: Chou RH, Lu CY, Wei-Lee, Fan JR, Yu YL, Shyu WC Tags: Cell Transplant Source Type: research

Crosstalk between cerebral endothelium and oligodendrocyte.
Abstract It is now relatively well accepted that the cerebrovascular system does not merely provide inert pipes for blood delivery to the brain. Cerebral endothelial cells may compose an embedded bunker of trophic factors that contribute to brain homeostasis and function. Recent findings suggest that soluble factors from cerebral endothelial cells nourish neighboring cells, such as neurons and astrocytes. Although data are strongest in supporting mechanisms of endothelial-neuron and/or endothelial-astrocyte trophic coupling, it is likely that similar interactions also exist between cerebral endothelial cells and o...
Source: Cellular and Molecular Life Sciences : CMLS - October 17, 2013 Category: Cytology Authors: Miyamoto N, Pham LD, Seo JH, Kim KW, Lo EH, Arai K Tags: Cell Mol Life Sci Source Type: research

FoxJ1-expressing cells contribute to neurogenesis in forebrain of adult rats: Evidence from in vivo electroporation combined with piggyBac transposon.
Abstract Ependymal cells in the lateral ventricular wall are considered to be post-mitotic but can give rise to neuroblasts and astrocytes after stroke in adult mice due to insult-induced suppression of Notch signaling. The transcription factor FoxJ1, which has been used to characterize mouse ependymal cells, is also expressed by a subset of astrocytes. Cells expressing FoxJ1, which drives the expression of motile cilia, contribute to early postnatal neurogenesis in mouse olfactory bulb. The distribution and progeny of FoxJ1-expressing cells in rat forebrain are unknown. Here we show using immunohistochemistry tha...
Source: Experimental Cell Research - September 25, 2013 Category: Cytology Authors: Devaraju K, Barnabe-Heider F, Kokaia Z, Lindvall O Tags: Exp Cell Res Source Type: research

Vascular endothelial growth factors (VEGFs) and stroke.
Abstract Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair, and the effects of transplanted stem cells in experimental stroke. Most of these actions involve VEGF-A and the VEGFR-2 receptor, but VEGF-B, placental growth factor, and VEGFR-1 have been implicated in some cases as well. VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke. PMID: 23475070 [PubMed - in process]
Source: Cellular and Molecular Life Sciences : CMLS - May 1, 2013 Category: Cytology Authors: Greenberg DA, Jin K Tags: Cell Mol Life Sci Source Type: research

Pages: 1  2  3  4  5  6