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Platelet bio-nanobubbles as microvascular recanalization nanoformulation for acute ischemic stroke lesion theranostics
Conclusions: In summary, platelet membrane-based nanobubbles for targeting acute ischemic lesions were developed as microvascular recanalization nanoformulation for acute ischemic stroke lesion theranostics. This biomimetic PNBs theranostic strategy will be valuable for ischemic stroke patients in the future.
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Mingxi Li, Yang Liu, Jinpeng Chen, Taotao Liu, Zhuxiao Gu, Jianqiong Zhang, Xiaochun Gu, Gaojun Teng, Fang Yang, Ning Gu Tags: Research Paper Source Type: research

Early Ultrafast Ultrasound Imaging of Cerebral Perfusion correlates with Ischemic Stroke outcomes and responses to treatment in Mice
Conclusion: We thus provide the proof of concept that in a mouse model of thromboembolic stroke with an intact skull, early ultrafast ultrasound can be indicative of responses to treatment and cerebral tissue fates following stroke. It brings new tools to study ischemic stroke in preclinical models and is the first step prior translation to the clinical settings.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Vincent Hingot, Camille Brodin, Florent Lebrun, Baptiste Heiles, Audrey Chagnot, Merv é Yetim, Maxime Gauberti, Cyrille Orset, Mickael Tanter, Olivier Couture, Thomas Deffieux, Denis Vivien Tags: Research Paper Source Type: research

PET Detection of Cerebral Necrosis Using an Infarct-Avid Agent 2-Deoxy-2- 18 FFluoro- d -Glucaric Acid (FGA) in a Mouse Model of the Brain Stroke
ConclusionsAccumulation of FGA correlated well with the perfusion defect and inflammatory injury. As a PET agent, FGA has potential to image infarcted core in the brain stroke injury with high sensitivity, resolution, and specificity.
Source: Molecular Imaging and Biology - June 15, 2020 Category: Molecular Biology Source Type: research

Impact of hydroxytyrosol on stroke: tracking therapy response on neuroinflammation and cerebrovascular parameters using PET-MR imaging and on functional outcomes
Conclusion: An HT-enriched diet significantly increased the number of Iba-1+ microglia/macrophages in the post-ischemic area, inducing higher expression of anti-inflammatory markers while no clear-cut effect was observed. Also, HT did not affect recovery of the cerebrovascular parameters, including ADC and CBF.Altogether, our data indicated that a prolonged dietary intervention with HT, as a single component of the Mediterranean diet, induces molecular changes that may improve stroke outcomes. Therefore, we support the use of the Mediterranean diet as a multicomponent therapy approach after stroke.
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Cristina Barca, Maximilian Wiesmann, Jes ú s Calahorra, Lydia Wachsmuth, Christian D ö ring, Claudia Foray, Ali Heiradi, Sven Hermann, Maria Á ngeles Peinado, Eva Siles, Cornelius Faber, Michael Sch ä fers, Amanda J Kiliaan, Andreas H. Jacobs, Bastian Tags: Research Paper Source Type: research

Genetic variation in retinal vascular patterning predicts variation in pial collateral extent and stroke severity
Abstract The presence of a native collateral circulation in tissues lessens injury in occlusive vascular diseases. However, differences in genetic background cause wide variation in collateral number and diameter in mice, resulting in large variation in protection. Indirect estimates of collateral perfusion suggest that wide variation also exists in humans. Unfortunately, methods used to obtain these estimates are invasive and not widely available. We sought to determine whether differences in genetic background in mice result in variation in branch patterning of the retinal arterial circulation, and whether these...
Source: Angiogenesis - November 5, 2014 Category: Molecular Biology Source Type: research

Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke
Conclusion: Direct inhibition of smooth muscle myosin by AmBleb in pre-capillary SMCs significantly contribute to the improvement of cerebral blood reperfusion and brain functions suggesting that smooth muscle myosin inhibition may have promising potential in stroke therapies as a follow-up treatment of physical or chemical removal of the occluding thrombus.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: M á t é P é nzes, Demeter T ú r ó s, Domokos M á th é , Kriszti á n Szigeti, Nikolett Heged ű s, Anna Á gnes Rauscher, P é ter T ó th, Ivan Ivic, Parasuraman Padmanabhan, Gabriella P á l, Á rp á d Dobolyi, M á t é Gyimesi, Andr á s M � Tags: Research Paper Source Type: research

The potential therapeutic effect of phosphodiesterase 5 inhibitors in the acute ischemic stroke (AIS)
In conclusion, PDE5 inhibitors may have potential roles in the management of AIS through modulation of CBF, cAMP/cGMP/NO pathway, neuroinflammation, and inflammatory signaling pathways. Preclinical and clinical studies are recommended in this regard.PMID:37395897 | DOI:10.1007/s11010-023-04793-1
Source: Molecular Medicine - July 3, 2023 Category: Molecular Biology Authors: Raed AlRuwaili Hayder M Al-Kuraishy Mubarak Alruwaili Amira Karam Khalifa Athanasios Alexiou Marios Papadakis Hebatallah M Saad Gaber El-Saber Batiha Source Type: research

CPCGI confers neuroprotection by enhancing blood circulation and neurological function in cerebral ischemia/reperfusion rats.
Authors: Miao Y, Wang R, Wu H, Yang S, Qiu Y Abstract The current study used a rat middle cerebral artery occlusion (MCAO) model with the aim to explore the effects of compound porcine cerebroside and ganglioside injection (CPCGI) on brain ischemia/reperfusion injury in rats. Improvement in the infarct‑side microcirculation and the overall recovery of neurological function were detected by triphenyltetrazolium chloride staining, laser speckle blood flow monitoring, latex perfusion, immunofluorescence and immunoblotting. The results revealed that administration of CPCGI for 7 consecutive days following ischemic ...
Source: Molecular Medicine Reports - July 21, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Arrhythmia susceptibility in a rat model of acute atrial dilation
In conclusion, CV decrease is not sufficient to promote arrhythmias; enlargement of atrial surface is essential to create a substrate for acute reentry-based arrhythmias.
Source: Progress in Biophysics and Molecular Biology - February 14, 2020 Category: Molecular Biology Source Type: research

Role of sex hormones in modulating myocardial perfusion and coronary flow reserve
CONCLUSION: Our experimental data in mice indicate that sex differences in myocardial perfusion are primarily driven by testosterone. Given the diagnostic importance of PET-MPI in clinical routine, further studies are warranted to determine whether testosterone levels affect the interpretation of myocardial perfusion findings in patients.PMID:35024889 | DOI:10.1007/s00259-022-05675-2
Source: Molecular Medicine - January 13, 2022 Category: Molecular Biology Authors: Ahmed Haider Susan Bengs Angela Portmann Alexia Rossi Hazem Ahmed Dominik Etter Geoffrey I Warnock Nidaa Mikail Muriel Gr ämer Alexander Meisel Livio Gisler Caitlin Jie Claudia Keller Sebastian Kozerke Bruno Weber Roger Schibli Linjing Mu Philipp A Kaufm Source Type: research

60 Years of Achievements by KSNM in Neuroimaging Research
Nucl Med Mol Imaging. 2022 Feb;56(1):3-16. doi: 10.1007/s13139-021-00727-1. Epub 2022 Jan 15.ABSTRACTNuclear medicine neuroimaging is able to show functional and molecular biologic abnormalities in various neuropsychiatric diseases. Therefore, it has played important roles in the clinical diagnosis and in research on the normal and pathological states of the brain. More than 400 outstanding studies have been conducted by Korean researchers over the past 60 years. In the 1990s, when multiheaded single-photon emission computed tomography (SPECT) scanners were first introduced in South Korea, stroke research using brain perfu...
Source: Molecular Medicine - February 21, 2022 Category: Molecular Biology Authors: Jae Seung Kim Hye Joo Son Minyoung Oh Dong Yun Lee Hae Won Kim Jungsu Oh Source Type: research