Filtered By:
Specialty: Radiology
Procedure: SPECT

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 17 results found since Jan 2013.

TSPO imaging in stroke: from animal models to human subjects
Abstract Stroke is a major health problem in developed countries and neuroinflammation has emerged over the last 2 decades as major contributor to the pathophysiological processes of brain damage following stroke. PET imaging of the translocator 18 kDa protein (TSPO) provides a unique non-invasive point of access to neuroinflammatory processes and more specifically microglial and astrocytic reaction after stroke in both animal models and patients. Here, we are reviewing both the experimental and clinical literature about in vivo TSPO PET and SPECT imaging in stroke. The studies in animal models of stroke revi...
Source: Clinical and Translational Imaging - September 30, 2015 Category: Radiology Source Type: research

Presence and extent of coronary calcified plaque evaluated by coronary computed tomographic angiography are independent predictors of ischemic stroke in patients with suspected coronary artery disease
Abstract Although ischemic stroke and coronary artery disease (CAD) share common risk factors and pathophysiology, the risk of stroke in patients with CAD remains unclear. We sought to evaluate the risk of ischemic stroke in patients with suspected CAD according to coronary computed tomographic angiography (CCTA) and single-photon emission computed tomography (SPECT) findings. Presence, severity, and extent of CAD were evaluated in 1137 patients with suspected CAD who underwent CCTA and SPECT. Primary outcome was the occurrence of ischemic stroke. During follow-up (median 26 months), ischemic stroke was obse...
Source: The International Journal of Cardiovascular Imaging - September 17, 2015 Category: Radiology Source Type: research

Radionuclide Imaging in Ischemic Stroke
Ischemic stroke is caused by interruption or significant impairment of blood supply to the brain, which leads to a cascade of metabolic and molecular alterations resulting in functional disturbance and morphologic damage. The changes in regional cerebral blood flow and regional metabolism can be assessed by radionuclide imaging, especially SPECT and PET. SPECT and PET have broadened our understanding of flow and metabolic thresholds critical for maintenance of brain function and morphology: PET was essential in the transfer of the concept of the penumbra to clinical stroke and thereby had a great impact on developing treat...
Source: Journal of Nuclear Medicine - November 3, 2014 Category: Radiology Authors: Heiss, W.-D. Tags: Continuing Education Source Type: research

Brain perfusion and upper limb motor function: A pilot study on the correlation between evolution of asymmetry in cerebral blood flow and improvement in Fugl–Meyer Assessment score after rTMS in chronic post-stroke patients
Conclusion Changes in AI less than zero reflect improved perfusion, suggesting that upper limb motor function improvement in post-stroke patients reflects evolution of brain perfusion in the superior and middle frontal areas.
Source: Journal of Neuroradiology - October 12, 2014 Category: Radiology Source Type: research

Crossed cerebellar diaschisis after stroke identified noninvasively with cerebral blood flow-weighted arterial spin labeling MRI
Conclusions CCD correlated with cerebellar CVR asymmetry and Wallerian degeneration. These findings suggest that noninvasive MRI may be a useful alternative to PET or SPECT to study structural correlates and clinical consequences of CCD following supratentorial stroke.
Source: European Journal of Radiology - November 10, 2015 Category: Radiology Source Type: research

Assessment of cerebral blood perfusion changes after neurorehabilitation therapy in patients with middle cerebral artery infarction: An acetazolamide ‐challenged SPECT study
Abstract Stroke is a leading cause of death and disability worldwide. Although neuroimaging has been used to examine brain changes related to recovery from stroke, cerebral perfusion changes after rehabilitation have yet to be elucidated. The aim of this study was to evaluate the regional cerebral blood flow (rCBF) changes and their associations with gross motor functions after neurorehabilitation therapy in stroke patients. A total of 7 patients with middle cerebral artery (MCA) infarction received conventional neurorehabilitation therapy twice per day for 4‐6 weeks on admission. Brain perfusion images were acquired bef...
Source: International Journal of Imaging Systems and Technology - November 11, 2017 Category: Radiology Authors: Kyung ‐Sool Jang, Jooyeon J. Im, Yong‐An Chung, Sung‐Woo Chung, Hyeonseok S. Jeong, Min‐Wook Kim Tags: RESEARCH ARTICLE Source Type: research

In Vivo Quantification of Cerebral Translocator Protein Binding in Humans Using 6-Chloro-2-(4'-123I-Iodophenyl)-3-(N,N-Diethyl)-Imidazo1,2-aPyridine-3-Acetamide SPECT
Conclusion: As demonstrated within a group of stroke and GBM patients, 123I-CLINDE SPECT can be used for quantitative assessment of TSPO expression in vivo. Because of the absence of a region devoid of TSPO, reference tissue models should be used with caution. The 2-tissue-compartment kinetic analysis of a 90-min dynamic scan with arterial blood sampling is recommended for the quantification of 123I-CLINDE binding with SPECT.
Source: Journal of Nuclear Medicine - December 1, 2014 Category: Radiology Authors: Feng, L., Svarer, C., Thomsen, G., de Nijs, R., Larsen, V. A., Jensen, P., Adamsen, D., Dyssegaard, A., Fischer, W., Meden, P., Krieger, D., Moller, K., Knudsen, G. M., Pinborg, L. H. Tags: Clinical Investigations Source Type: research

In Vivo Molecular Imaging of Thrombosis and Thrombolysis Using a Fibrin-Binding Positron Emission Tomographic Probe Molecular Imaging
Conclusions— We demonstrated that FBP7 is suitable for molecular imaging of thrombosis and thrombolysis in vivo and represents a promising candidate for bench-to-bedside translation.
Source: Circulation: Cardiovascular Imaging - July 15, 2014 Category: Radiology Authors: Ay, I., Blasi, F., Rietz, T. A., Rotile, N. J., Kura, S., Brownell, A. L., Day, H., Oliveira, B. L., Looby, R. J., Caravan, P. Tags: PET and SPECT Molecular Imaging Source Type: research

Feasibility of biventricular volume and function assessment using first-pass gated 15 O-water PET
ConclusionsBiventricular volume and function assessment are achievable using the first-pass PET, and LV parameters correlate well with those derived from gated myocardial SPECT.
Source: EJNMMI Research - September 17, 2018 Category: Radiology Source Type: research

Translocator protein and new targets for neuroinflammation
Abstract The mitochondrial translocator protein (18 kDa; TSPO) is involved in a wide array of physiological processes importantly including cholesterol transport, steroidogenesis and immunomodulation. In the central nervous system (CNS), TSPO expression regionally increases in glial cells upon brain insult with a differential pattern suggestive of cell-specific functions in inflammation and repair. These properties have made TSPO a valuable marker to assess the state, and progression of diverse neurological and psychiatric conditions, including traumatic brain injury, stroke, neurodegenerative diseases, anxiety, ...
Source: Clinical and Translational Imaging - November 16, 2015 Category: Radiology Source Type: research

Effect of local mild hypothermia on regional cerebral blood flow in patients with acute intracerebral hemorrhage assessed by 99mTc-ECD SPECT imaging.
CONCLUSION: Local mild hypothermia could significantly increase rCBF and improve clinical outcome in ICH patients as evaluated by <formula>^{99m}</formula>Tc-ECD SPECT study. PMID: 25567410 [PubMed - indexed for MEDLINE]
Source: Journal of X-Ray Science and Technology - January 25, 2016 Category: Radiology Tags: J Xray Sci Technol Source Type: research

3D-printed kidney helps optimize SPECT/CT quantification
Low-cost, 3D-printed kidney phantoms provide shape-specific details that improve...Read more on AuntMinnie.comRelated Reading: 3D-printed model helps prepare for stroke clot removal 3D printing shortens hip surgery times, lowers costs 3D printing helps evaluate leaks after TAVR procedures New therapeutic agent could treat prostate cancer 3D-printed kidney phantom advances SPECT/CT calibration
Source: AuntMinnie.com Headlines - December 5, 2017 Category: Radiology Source Type: news

3D-printed model reproduces real prostate properties
Researchers from Minnesota have used a 3D printer to generate patient-specific...Read more on AuntMinnie.comRelated Reading: 3D-printed kidney helps optimize SPECT/CT quantification 3D-printed prosthetics improve surgery for hearing loss 3D printing lowers risk and cost of testing FFR-CT How radiologists can optimize their role in 3D printing 3D-printed model helps prepare for stroke clot removal
Source: AuntMinnie.com Headlines - December 28, 2017 Category: Radiology Source Type: news

3D-printed breast biopsy device boosts accuracy
Researchers from the Netherlands have developed a 3D-printed robot-guided device...Read more on AuntMinnie.comRelated Reading: 3D-printed model reproduces real prostate properties 3D printing aids simulation of CT- and MR-guided ablation How to create low-cost, multicolor 3D-printed models 3D-printed kidney helps optimize SPECT/CT quantification 3D-printed model helps prepare for stroke clot removal
Source: AuntMinnie.com Headlines - January 10, 2018 Category: Radiology Source Type: news