Filtered By:
Specialty: Biology

This page shows you your search results in order of relevance. This is page number 5.

Order by Relevance | Date

Total 656 results found since Jan 2013.

Monoacylglycerol lipase inhibitor, JZL-184, confers neuroprotection in the mice middle cerebral artery occlusion model of stroke
Discussion Based on the results, it seems that JZL can be considered as a good candidate for inhibition of stroke secondary injury in the case of delayed treatment.
Source: Life Sciences - March 8, 2018 Category: Biology Source Type: research

High intensity exercise preconditioning provides differential protection against brain injury following experimental stroke
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Rasoul Rezaei, Sanaz Nasoohi, Abbas Haghparast, Fariba Khodagholi, Mohammad Reza Bigdeli, Maryam NourshahiAbstractAimsDifferent modes of physical activity provide cerebrovascular protection against thromboembolic events. Based on recent reports high intensity exercise protocols appear to raise cerebral VEGF levels leading to efficient cerebral angiogenesis. The present study aims to address if moderate continuous training (MCT) and high intensity interval training (HIT) differ in preconditioning against ischemic stroke.MethodsWistar rats were subje...
Source: Life Sciences - July 5, 2018 Category: Biology Source Type: research

Trigonelline therapy confers neuroprotection by reduced glutathione mediated myeloperoxidase expression in animal model of ischemic stroke
Publication date: Available online 7 November 2018Source: Life SciencesAuthor(s): Kanta Pravalika, Deepaneeta Sarmah, Harpreet Kaur, Kanchan Vats, Jackson Saraf, Madhuri Wanve, Kiran Kalia, Anupom Borah, Dileep R. Yavagal, Kunjan R. Dave, Pallab BhattacharyaAbstractAimStroke is devastating with a limited choice of intervention. Many pharmacological entities are available but none of them have evolved successfully in counteracting the multifaceted molecular alterations following stroke. Myeloperoxidase (MPO) has been reported to play an important role in neuroinflammation following neurodegenerative diseases. Therefore, usi...
Source: Life Sciences - November 8, 2018 Category: Biology Source Type: research

A brain-stellate ganglion-atrium network regulates atrial fibrillation vulnerability through macrophages in acute stroke
Publication date: Available online 9 October 2019Source: Life SciencesAuthor(s): Youcheng Wang, Xiaoxing Xiong, Baojun Xie, Jia Liu, Mei Yang, Junkui Yin, Liuliu Zi, Xi Wang, Yanhong Tang, Congxin Huang, Haixia Fu, Qingyan ZhaoAbstractAimsNew-onset atrial fibrillation (AF) is frequently observed following acute stroke. The aim of this study was to investigate the effects of the brain-stellate ganglion-atrium network on AF vulnerability in a canine model with acute middle cerebral artery occlusion (MCAO).Materials and methodsTwenty-six dogs were randomly divided into the sham-operated group (n = 6), acute stroke (AS) gr...
Source: Life Sciences - October 10, 2019 Category: Biology Source Type: research

Fuzzy cognitive map based approach for determining the risk of ischemic stroke
In this study, the soft computing method known as fuzzy cognitive mapping was proposed for diagnosis of the risk of ischemic stroke. Non-linear Hebbian learning method was used for fuzzy cognitive maps training. In the proposed method, the risk rate for each person was determined based on the opinions of the neurologists. The accuracy of the proposed model was tested using 10-fold cross-validation, for 110 real cases, and the results were compared with those of support vector machine and K-nearest neighbours. The proposed system showed a superior performance with a total accuracy of (93.6 ± 4.5)%. The da...
Source: IET Systems Biology - November 29, 2019 Category: Biology Source Type: research

The neuroprotective properties of the superoxide dismutase mimetic tempol correlate with its ability to reduce pathological glutamate release in a rodent model of stroke.
Abstract The contribution of oxidative stress to ischemic brain damage is well established. Nevertheless, for unknown reasons, several clinically tested antioxidant therapies failed to show benefits in human stroke. Based on our previous in vitro work, we hypothesized that the neuroprotective potency of antioxidants is related to their ability to limit release of the excitotoxic amino acids, glutamate and aspartate. We explored the effects of two antioxidants, tempol and edaravone, on amino acid release in the brain cortex, in a rat model of transient occlusion of the middle cerebral artery (MCAo). Amino acid leve...
Source: Free Radical Biology and Medicine - September 12, 2014 Category: Biology Authors: Dohare P, Hyzinski-García MC, Vipani A, Bowens NH, Nalwalk JW, Feustel PJ, Keller RW, Jourd'heuil D, Mongin AA Tags: Free Radic Biol Med Source Type: research

Targeting formyl peptide receptor 2 reduces leukocyte-endothelial interactions in a murine model of stroke Research Communication
This study investigated the pharmacologic potential of targeting an endogenous anti-inflammatory circuit via formyl peptide receptor (FPR) 2/lipoxin receptor (ALX) (Fpr2/3 in mouse) in global cerebral I/R. Mice (C57BL/6 and Fpr2/3–/–) were subjected to bilateral common carotid artery occlusion, followed by reperfusion and treatment with FPR agonists: AnxA1Ac2–26 [Annexin A1 mimetic peptide (Ac-AMVSEFLKQAWFIENEEQEYVQTVK), 2.5 μg/kg] and 15-epimer-lipoxin A4 (15-epi-LXA4; FPR2/ALX specific, 12.5 and 100 ng/kg). Leukocyte-endothelial (L-E) interactions in the cerebral microvasculature were then quantified...
Source: FASEB Journal - April 30, 2015 Category: Biology Authors: Smith, H. K., Gil, C. D., Oliani, S. M., Gavins, F. N. E. Tags: Research Communication Source Type: research

The thick left ventricular wall of the giraffe heart normalises wall tension, but limits stroke volume and cardiac output RESEARCH ARTICLE
Morten Smerup, Mads Damkjaer, Emil Brondum, Ulrik T. Baandrup, Steen Buus Kristiansen, Hans Nygaard, Christian Aalkjaer, Cathrine Sauer, Rasmus Buchanan, Mads Frost Bertelsen, Kristine Ostergaard, Carsten Grondahl, Geoffrey Candy, J. Michael Hasenkam, Niels H. Secher, Peter Bie, and Tobias WangGiraffes – the tallest extant animals on Earth – are renowned for their high central arterial blood pressure, which is necessary to secure brain perfusion. The pressure which may exceed 300 mmHg has historically been attributed to an exceptionally large heart. Recently, this has been refuted by several studies demonstrati...
Source: Journal of Experimental Biology - December 7, 2015 Category: Biology Authors: Smerup, M., Damkjaer, M., Brondum, E., Baandrup, U. T., Kristiansen, S. B., Nygaard, H., Aalkjaer, C., Sauer, C., Buchanan, R., Bertelsen, M. F., Ostergaard, K., Grondahl, C., Candy, G., Hasenkam, J. M., Secher, N. H., Bie, P., Wang, T. Tags: RESEARCH ARTICLE Source Type: research

Improved cardiac filling facilitates the postprandial elevation of stroke volume in Python regius RESEARCH ARTICLE
Sanne Enok, Gabriella Leite, Cleo Leite, Hans Gesser, Michael S. Hedrick, and Tobias WangTo accommodate the pronounced metabolic response to digestion, pythons increase both heart rate and elevate stroke volume, where the latter has been ascribed to a massive and fast cardiac hypertrophy. However, numerous recent studies show that heart mass rarely increases even upon ingestion of large meals, and we therefore explored the possibility that a rise in mean circulatory filling pressure (MCFP) serves to elevate venous pressure and cardiac filling during digestion. To this end, we measured blood flows and pressures in anaesthet...
Source: Journal of Experimental Biology - July 20, 2016 Category: Biology Authors: Enok, S., Leite, G., Leite, C., Gesser, H., Hedrick, M. S., Wang, T. Tags: RESEARCH ARTICLE Source Type: research

Potential therapeutic and protective effect of curcumin against stroke in the male albino stroke-induced model rats
Publication date: Available online 27 June 2017 Source:Life Sciences Author(s): Yuanyuan Zhang, Yi Yan, Yi Cao, Yongtao Yang, Qing Zhao, Rui Jing, Jiayi Hu, Juan Bao Aims The present study was carried out to understand the therapeutic effect of curcumin (CUR) against stroke in the experimental animal model. The study investigates the healing effect of CUR on mitochondrial dysfunction and inflammation. Materials and methods Male albino, Wistar strain rats were used for the induction of middle cerebral artery occlusion (MCAO), and reperfusion. Enzyme-linked immunosorbent assay (ELISA) was used for the determination of inter...
Source: Life Sciences - June 27, 2017 Category: Biology Source Type: research

A hydrodynamically active flipper-stroke in humpback whales.
Abstract A central paradigm of aquatic locomotion is that cetaceans use fluke strokes to power their swimming while relying on lift and torque generated by the flippers to perform maneuvers such as rolls, pitch changes and turns [1]. Compared to other cetaceans, humpback whales (Megaptera novaeangliae) have disproportionately large flippers with added structural features to aid in hydrodynamic performance [2,3]. Humpbacks use acrobatic lunging maneuvers to attack dense aggregations of krill or small fish, and their large flippers are thought to increase their maneuverability and thus their ability to capture prey....
Source: Current Biology - July 10, 2017 Category: Biology Authors: Segre PS, Seakamela SM, Meÿer MA, Findlay KP, Goldbogen JA Tags: Curr Biol Source Type: research