A brain-stellate ganglion-atrium network regulates atrial fibrillation vulnerability through macrophages in acute stroke

Publication date: Available online 9 October 2019Source: Life SciencesAuthor(s): Youcheng Wang, Xiaoxing Xiong, Baojun Xie, Jia Liu, Mei Yang, Junkui Yin, Liuliu Zi, Xi Wang, Yanhong Tang, Congxin Huang, Haixia Fu, Qingyan ZhaoAbstractAimsNew-onset atrial fibrillation (AF) is frequently observed following acute stroke. The aim of this study was to investigate the effects of the brain-stellate ganglion-atrium network on AF vulnerability in a canine model with acute middle cerebral artery occlusion (MCAO).Materials and methodsTwenty-six dogs were randomly divided into the sham-operated group (n = 6), acute stroke (AS) group (n = 7), stellate ganglion ablation (SGA) group (n = 6) and clodronate liposome (CL) group (n = 7). In the sham-operated group, dogs received craniotomy without MCAO. Cerebral ischemic model was established in AS dogs by right MCAO. Right MCAO along with SGA and CL injection into the atrium was performed in SGA and CL dogs, respectively. After 3 days, atrial electrophysiology, neural activity, and the phenotype and function of macrophages in the atrium were studied in all the dogs.Key findingsHigher AF inducibility (24.4 ± 4.4% versus 4.4 ± 2.2%, P 
Source: Life Sciences - Category: Biology Source Type: research

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Source: Journal of Biomedical Nanotechnology - Category: Nanotechnology Authors: Tags: Articles Source Type: research
Conclusion: The preliminary results showed that the system can be used in a clinical environment with positive effects on arm functional recovery. However, only the final results of the currently ongoing clinical trial will unveil the system's full potential. Significance: The presented hybrid robotic system is highly customizable, allows to monitor the daily performance, requires low supervision of the therapist, and might have the potential to enhance arm recovery after stroke.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
CONCLUSIONS: Valsalva thrombus was detected in 8.9% of patients following balloon-expandable THV implantation and was common in the LCC, but it did not increase the risk of adverse events after TAVI. PMID: 31746754 [PubMed - in process]
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
A subgroup analysis was conducted of patients with carotid atherosclerosis in the NAVIGATE (New Approach Rivaroxaban Inhibition of Factor Xa in a Global Trial Versus ASA to Prevent Embolism)-ESUS (Embolic Stroke of Undetermined Source) trial, which was an international, double-blinded, randomized phase 2 trial between December 2014 and September 2017.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Anticoagulation is not better than aspirin to prevent stroke in patients with carotid atherosclerosis Source Type: research
A randomized, prospective study from the United Kingdom and Australia was conducted between February 24, 2006 and June 17, 2013.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: There is no difference in treatment of carotid or vertebral artery dissection with antiplatelet vs anticoagulant therapy Source Type: research
Telomeres are repetitive nucleotides sequences localized to the ends of each individual chromosome. They are replicated during each cellular division, but with each cell cycle they become progressively shorter. The problem is short telomeres are associated with dysregulation of cellular events such as senescence or cell death. The shortening process is accelerated by exposure to stress, smoking, obesity, lack of exercise, and poor diet. Many refer to this process as one of our “biological clocks.” In long-term studies, shortened telomeres are associated with adverse health outcomes including atherosclerosis, st...
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research
AbstractPurposeCirculating caspase-3 levels at 24  h of ischemic stroke were found to be associated with poorer functional neurological outcome in a previous study. The aim of this study was to determine whether there is an association between serum caspase-3 levels and early mortality in patients with malignant middle cerebral artery infarction ( MMCAI).MethodsWe included patients with MMCAI defined as computer tomography showing ischemic changes in more than 50% of the middle cerebral artery territory and Glasgow Coma Scale  ≤ 8. Serum caspase-3 levels at days 1, 4, and 8 of MMCAI were determined.Re...
Source: Neurocritical Care - Category: Neurology Source Type: research
Publication date: Available online 20 November 2019Source: IJC Heart &VasculatureAuthor(s): Dominik Linz, Enrico Ammirati, Gheorghe-Andrei Dan, Jordi Heijman, Dobromir Dobrev
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
Publication date: Available online 21 November 2019Source: Canadian Journal of CardiologyAuthor(s): Gabriele Crimi, Claudio Montalto, Luca Angelo Ferri, Luigi Piatti, Irene Bossi, Nuccia Morici, Alessandro Mandurino-Mirizzi, Daniele Grosseto, Giovanni Tortorella, Stefano Savonitto, Stefano De Servi, Elderly-ACS 2 InvestigatorsABSTRACTBackgroundElderlies are underrepresented in clinical trials and registries and a gap of evidence exists for clinical decision making in the setting of acute coronary syndromes (ACS). We aimed to assess the prevalence and independent prognostic impact of valvular heart disease (VHD) diagnosed d...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
You get tired of playing the game - or banging your head against stone walls.  For weeks, I have been resolved to appear at tonight'sPublic Hearing at the old Asheboro Courthouse - in which Randolph County Commissioners will take up the matter of going into massive debt (by applying for a loan from the state) to keep Randolph Health from closing its doors in late January or February.But I cannot . . . and will not even try to . . . cram 22 years into 3 minutes.  I can actually make the statement in 8 or 9 minutes, but not 3.  The hospital has pontificated from its various soapboxes and manipulated the m...
Source: Dr.J's HouseCalls - Category: American Health Source Type: blogs
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