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Total 204 results found since Jan 2013.

Relative fractional anisotropy value using DTI: Can it help as a prognostic tool in anticipating the recovery of stroke patients?
Conclusion DTI is a prognostic tool in anticipating the recovery of the stroke patients. Moreover, the relative FA score works as more additive value in evaluation of the patient improvement.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - December 10, 2017 Category: Nuclear Medicine Source Type: research

Diffusion tensor magnetic resonance imaging in assessment of prognostic outcome of stroke patients
Conclusion DTI can visualize the changes in the integrity and orientation of the white matter tracts that are affected by cerebrovascular lesions which cannot be detected by conventional MRI. By MR tractography, we can detect the pattern of white matter tract affection that offers a potential tool for correlating the clinical outcome with the imaging findings.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - April 25, 2015 Category: Nuclear Medicine Source Type: research

Reliability of magnetic susceptibility weighted imaging in detection of cerebral microbleeds in stroke patients
Conclusion SWI is an important reliable technique allows accurate detection of CMBs occurring in association with hemorrhage in acute and chronic stroke and should be included in the protocols for assessment of stroke to help in choice of proper treatment and prediction of future attacks.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - March 10, 2017 Category: Nuclear Medicine Source Type: research

Microglial activation in recent ischemic stroke: comparison of two TSPO tracers
Conclusion: The apparent intensity of microglial activation in ischemic stroke is closely comparable between 18F-GE180 and 11C-(R)-PK11195 PET. Research Support: The study is funded by a grant from NIHR and supported by GEHC and INMIND (EC FP7).
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Herholz, K., Hinz, R., Visi, E., Trigg, W., McDonald, K., Punter, M., Majid, A., Gerhard, A. Tags: Neurology Posters Source Type: research

A study of the brain protective effects and mechanism of stroke rats with allopurinol by 18F- FMISO PET imaging
Conclusion (1) 18F-FMISO imaging can accurately show the cerebral ischemia penumbra . (2) Allopurinol can reduce the degree of hypoxia of ischemic brain tissue.(3) Allopurinol affects the 8F-FMISO uptake of brain tissues by the activity of xanthine oxidase.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Li, Y., Li, A. Tags: Basic Science I Source Type: research

11C-DPA-713 Versus 18F-GE-180: A Preclinical Comparison of Translocator Protein 18 kDa PET Tracers to Visualize Acute and Chronic Neuroinflammation in a Mouse Model of Ischemic Stroke
Conclusion: 11C-DPA-713 and 18F-GE-180 PET enable detection of neuroinflammation at acute and chronic time points after cerebral ischemia in mice. 11C-DPA-713 PET reflects the extent of microglial activation in infarcted distal middle cerebral artery occlusion mouse brain tissue more accurately than 18F-GE-180 and appears to be slightly more sensitive. These results highlight the potential of 11C-DPA-713 for tracking microglial activation in vivo after stroke and warrant further investigation in both preclinical and clinical settings.
Source: Journal of Nuclear Medicine - January 2, 2019 Category: Nuclear Medicine Authors: Chaney, A., Cropper, H. C., Johnson, E. M., Lechtenberg, K. J., Peterson, T. C., Stevens, M. Y., Buckwalter, M. S., James, M. L. Tags: Basic Source Type: research

Super-early images of brain perfusion SPECT using 123 I-IMP for the assessment of hyperperfusion in stroke patients
ConclusionsThe addition of super-early imaging to the conventional early imaging aids assessment of postischemic hyperperfusion by123I-IMP brain perfusion SPECT and may contribute to management of stroke patients in the era of reperfusion therapy.
Source: Annals of Nuclear Medicine - September 1, 2018 Category: Nuclear Medicine Source Type: research

Quantitative assessment of tricuspid regurgitation using right and left ventricular stroke volumes obtained from tomographic equilibrium radionuclide ventriculography
ConclusionTR assessment using the t-ERV correlates well with PISA from TTE in patients referred for right ventricular systolic function assessment.
Source: Journal of Nuclear Cardiology - June 13, 2019 Category: Nuclear Medicine Source Type: research

Risk stratification for large artery or chronic coronary artery disease-related ischemic stroke in octogenarians undergoing exercise stress myocardial perfusion imaging: A cohort study
Conclusion Exercise-MPI in octogenarians can provide risk stratification markers for LACCIS.
Source: Journal of Nuclear Cardiology - December 16, 2015 Category: Nuclear Medicine Source Type: research

18F-Choline Uptake in Acute Ischemic Stroke
Abstract: A 75-year-old man with a history of prostate cancer was referred to our department to perform 18F-choline (FCH) PET/CT. FCH PET/CT showed a markedly increased uptake in the right temporoparietal junction brain. Three weeks earlier, acute ischemic stroke was diagnosed in the right temporoparietal junction brain on diffusion-weighted sequence and thrombosis in a distal branch of the right middle cerebral artery on MR angiography. Choline precursors promote repair and growth of cell membranes in neurologic diseases, so FCH PET/CT uptake could be explained by repair processes during early outcome of acute ischemic stroke.
Source: Clinical Nuclear Medicine - January 10, 2017 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Validation of MRI Determination of the Penumbra by PET Measurements in Ischemic Stroke
The concept of the ischemic penumbra was formulated on the basis of animal experiments showing functional impairment and electrophysiologic disturbances with decreasing flow to the brain below defined values (the threshold for function) and irreversible tissue damage with blood supply further decreased (the threshold for infarction). The perfusion range between these thresholds was termed the "penumbra," and restitution of flow above the functional threshold was able to reverse the deficits without permanent damage. In further experiments, the dependency of the development of irreversible lesions on the interaction of the ...
Source: Journal of Nuclear Medicine - January 31, 2017 Category: Nuclear Medicine Authors: Heiss, W.-D., Zaro Weber, O. Tags: The State of the Art Source Type: research

68Ga-DOTATATE Uptake in Ischemic Stroke
Abstract A 76-year-old man known to have a pancreatic neuroendocrine tumor with hepatic and lymph nodes metastasis had a follow-up 68Ga-DOTATATE PET/CT before 177Lu-DOTATATE therapy. A new cerebral lesion expressing somatostatin receptors was discovered in the right temporal lobe, suggestive of an ischemic stroke territory. This was later confirmed from the hospital chart where an ischemic stroke was described a month ago.
Source: Clinical Nuclear Medicine - December 8, 2017 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Polyoxometalate nanoclusters act as broad-spectrum antioxidants to alleviate ischemic stroke by intrathecal injection
Conclusion: Intrathecal injection significantly improved the delivery and efficacy of POM nanoclusters to the brain, resulting in the rapid accumulation of POM nanoclusters in the ischemic penumbra. Due to this, we confirmed that the POM nanoclusters could be used as nano-antioxidants to inhibit oxidative stress as well as inflammatory damage effectively.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Rosenkrans, Z., Li, S., Jiang, D., NI, D., Engle, J., Cai, W. Tags: Center for Molecular Imaging Innovation & amp; Translation (CMIIT) YIA Symposium Source Type: research

Incidental 68Ga-DOTATOC PET/CT Uptake in Hemorrhagic Transformation of Stroke in a Patient With Cervical Paraganglioma
We present a case of a 75-year-old woman with clinical suspicion of stroke whose cranial CT showed ischemic changes in right precentral region, without visible vascular occlusion, and a right vagal lesion suggestive of paraganglioma. Two weeks later, 68Ga-DOTATOC PET/CT with IV iodine-based contrast administration (Biograph 6 True Point equipment; Siemens) was performed for characterization of this lesion and staging. Intraparenchymal 68Ga-DOTATOC uptake was visualized in right frontal lobe suggestive of hemorrhagic transformation of the previous stroke.
Source: Clinical Nuclear Medicine - November 10, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

18 F-GE-180: a novel TSPO radiotracer compared to 11 C-R-PK11195 in a preclinical model of stroke
Conclusion The in vivo binding characteristics of 18F-GE-180 demonstrate a better signal to noise ratio than 11C-R-PK11195 due to both a better signal in the lesion and lower nonspecific binding in healthy tissue. These results provide evidence that 18F-GE-180 is a strong candidate to replace 11C-R-PK11195.
Source: European Journal of Nuclear Medicine and Molecular Imaging - February 13, 2015 Category: Nuclear Medicine Source Type: research