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Rivaroxaban: an oral factor xa inhibitor.
CONCLUSIONS: Based on the findings of the studies reported in this review, rivaroxaban is an effective option for the prevention of VTE after orthopedic surgery, stroke prevention for nonvalvular AF, and treatment of VTE. At this time, rivaroxaban cannot be recommended for secondary risk reduction after ACS because of the increased bleeding risk. PMID: 23328267 [PubMed - in process]
Source: Clinical Therapeutics - January 1, 2013 Category: Drugs & Pharmacology Authors: Thomas TF, Ganetsky V, Spinler SA Tags: Clin Ther Source Type: research

Safety and Efficacy of Tirofiban Bridging Therapy During a Hybrid Carotid Artery Stenting and Off-Pump Coronary Artery Bypass Grafting Surgery: A Single-Center Study
This study evaluated the safety and efficacy of tirofiban as a bridging therapy after a hybrid CAS + CABG surgery.METHODS: Between June 2018 and February 2022, a total of 45 patients undergoing a hybrid CAS + off-pump CABG surgery were divided into either the control group (standard dual antiplatelet therapy postsurgery, n = 27) or the tirofiban group (tirofiban bridging + dual antiplatelet therapy, n = 18). The 30-day outcome was compared between the 2 groups, and the primary end points included stroke, postoperative myocardial infarction, and death.FINDINGS: Two patients (7.41%) from the control group experienced a strok...
Source: Clinical Therapeutics - February 21, 2023 Category: Drugs & Pharmacology Authors: Changcheng Liu Shipan Wang Yuan Xue Jiantao Wang Haiyang Li Source Type: research

Cost-Effectiveness of 12-Month Treatment With Ticagrelor Compared With Clopidogrel in the Management of Acute Coronary Syndromes.
CONCLUSIONS: When assessed from the perspective of the Australian health care system, ticagrelor is likely to be cost-effective compared with clopidogrel in preventing downstream morbidity and mortality associated with ACS. PMID: 23891361 [PubMed - as supplied by publisher]
Source: Clinical Therapeutics - July 26, 2013 Category: Drugs & Pharmacology Authors: Liew D, De Abreu Lourenço R, Adena M, Chim L, Aylward P Tags: Clin Ther Source Type: research

Clinical and Economic Burden in Patients with Diagnosis of Peripheral Arterial Disease in a Claims Database in Japan.
Abstract PURPOSE: The effect of peripheral arterial disease (PAD) among young and middle-aged adults can be significant, but no previous study has examined the prognosis and the associated health care cost of the disease in this population. We evaluated the clinical and economic burden of PAD in patients from a large claims database to clarify the effect of the disease on a relatively young working Japanese population. METHODS: Patients aged ≥45 and ≤64 years with first PAD diagnosis between 2005 and 2011 comprised the PAD cohort (n = 362); an age- and sex-matched non-PAD comparison cohort (n = 362) was a...
Source: Clinical Therapeutics - July 7, 2014 Category: Drugs & Pharmacology Authors: Hosaka A, Miyata T, Onishi Y, Liao L, Zhang Q Tags: Clin Ther Source Type: research

Could intensive anti-hypertensive therapy produce the "J-curve effect" in patients with coronary artery disease and hypertension after revascularization?
CONCLUSIONS: For the patients who had CAD and hypertension, intensive anti-hypertensive therapy could produce the "J-curve effect" after revascularization with the optimal blood pressure (BP) range being 120-130/75-80 mmHg. PMID: 27097958 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 23, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Evaluation of Prescribing Practices and Outcomes Using Direct-Acting Oral Anticoagulants After Cardiac Surgery
Clin Ther. 2021 May 30:S0149-2918(21)00203-4. doi: 10.1016/j.clinthera.2021.04.009. Online ahead of print.ABSTRACTPURPOSE: Cardiac surgery patients frequently require anticoagulation. Warfarin remains the preferred agent, and a few trials have reported negative outcomes with the use of direct-acting oral anticoagulants (DOACs) in these patients. Therefore, limited literature exists that supports the dosing, safety, and efficacy of DOACs within the cardiac surgery population.METHODS: This single-center, retrospective analysis was conducted at a tertiary academic medical center. All data were extrapolated from electronic med...
Source: Clinical Therapeutics - June 3, 2021 Category: Drugs & Pharmacology Authors: Dareen M Kanaan Bryan M Cook Julie Kelly Rhynn Malloy Source Type: research

Intra-aortic balloon counterpulsation - Basic principles and clinical evidence.
Abstract Intra-aortic balloon pump (IABP) counterpulsation has been the most widely used left ventricular assist device for nearly five decades. Due to diastolic inflation and systolic deflation, coronary blood flow is increased and afterload decreased translating into augmentation of oxygen supply and lowering of oxygen demand. However, IABP may be associated with serious complications, including major bleeding, stroke, local and systemic infections and vascular complications. These might counterbalance the potential beneficial hemodynamic effects. In clinical routine, IABP is mainly used in high-risk patients wi...
Source: Vascular Pharmacology - December 28, 2013 Category: Drugs & Pharmacology Authors: de Waha S, Desch S, Eitel I, Fuernau G, Lurz P, Sandri M, Schuler G, Thiele H Tags: Vascul Pharmacol Source Type: research

Reprint of "Intra-aortic balloon counterpulsation - Basic principles and clinical evidence"
Abstract Intra-aortic balloon pump (IABP) counterpulsation has been the most widely used left ventricular assist device for nearly five decades. Due to diastolic inflation and systolic deflation, coronary blood flow is increased and afterload decreased translating into augmentation of oxygen supply and lowering of oxygen demand. However, IABP may be associated with serious complications, including major bleeding, stroke, local and systemic infections and vascular complications. These might counterbalance the potential beneficial hemodynamic effects. In clinical routine, IABP is mainly used in high-risk patients wi...
Source: Vascular Pharmacology - March 18, 2014 Category: Drugs & Pharmacology Authors: de Waha S, Desch S, Eitel I, Fuernau G, Lurz P, Sandri M, Schuler G, Thiele H Tags: Vascul Pharmacol Source Type: research

Perioperative Landiolol Administration reduces Atrial Fibrillation after Cardiac Surgery: A Meta-analysis of Randomized Controlled Trials.
CONCLUSION: Landiolol administration reduces the incidence of POAF after cardiac surgery and is well tolerated. PMID: 24756366 [PubMed - as supplied by publisher]
Source: Advances in Therapy - April 23, 2014 Category: Drugs & Pharmacology Authors: Sakamoto A, Hamasaki T, Kitakaze M Tags: Adv Ther Source Type: research

Clevidipine: A Review of Its Use for Managing Blood Pressure in Perioperative and Intensive Care Settings
In conclusion, intravenous clevidipine is a valuable agent for the management of BP in perioperative and intensive care settings.
Source: Drugs - October 14, 2014 Category: Drugs & Pharmacology Source Type: research

Coronary Revascularization in Chronic and End-Stage Renal Disease: A Systematic Review and Meta-analysis
Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) on dialysis have an increased risk for cardiovascular mortality and morbidity secondary to occlusive coronary artery disease. Optimal revascularization strategy is unclear in this high-risk population. We have performed a meta-analysis to compare coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI) in patients with ESRD and CKD. We searched PubMed, Ovid, MEDLINE, CINAHL, and EMBASE (1980–2013) and found 17 trials (N = 33,584) in the ESRD arm and 6 studies (n = 15,493) in the CKD arm. Two investigators independe...
Source: American Journal of Therapeutics - January 1, 2016 Category: Drugs & Pharmacology Tags: Original Articles Source Type: research

Purine metabolite-based machine learning models for risk prediction, prognosis, and diagnosis of coronary artery disease
Biomed Pharmacother. 2021 Jul;139:111621. doi: 10.1016/j.biopha.2021.111621. Epub 2021 May 10.ABSTRACTAlterations in xanthine oxidase activity are known to be pathologically influential on coronary artery disease (CAD), but the association between purine-related blood metabolites and CAD has only been partially elucidated. We performed global metabolomics profiling and network analysis on blood samples from the Wonju and Pyeongchang (WP) cohort study (n = 2055) to elucidate the importance of purine related metabolites associated with potential CAD risk. Then, 5 selected serum metabolites were quantified from the WP cohort,...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: Sunhee Jung Eunyong Ahn Sang Baek Koh Sang-Hak Lee Geum-Sook Hwang Source Type: research

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