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Specialty: Nuclear Medicine
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Total 204 results found since Jan 2013.
Demarcation of Sepsis-Induced Peripheral and Central Acidosis with pH (Low) Insertion Cycle Peptide
Conclusion: Here, we demonstrate that a pH-sensitive PET tracer specifically detects acidosis in regions associated with sepsis-driven proinflammatory responses. This study suggests that [64Cu]Cu-pHLIC is a valuable tool to noninvasively assess acidosis associated with both central and peripheral innate immune activation.
Source: Journal of Nuclear Medicine - August 31, 2020 Category: Nuclear Medicine Authors: Henry, K. E., Chaney, A. M., Nagle, V. L., Cropper, H. C., Mozaffari, S., Slaybaugh, G., Parang, K., Andreev, O. A., Reshetnyak, Y. K., James, M. L., Lewis, J. S. Tags: Basic Source Type: research
Prognostic value of myocardial perfusion imaging with D-SPECT camera in patients with ischemia and no obstructive coronary artery disease (INOCA)
ConclusionsD-SPECT MPI provides excellent prognostic information, with a more severe prognosis in patients with abnormal D-SPECT MPI. INOCA patients with abnormal D-SPECT MPI experience a poor prognosis similar to that of patients with obstructive CAD.
Source: Journal of Nuclear Cardiology - September 29, 2020 Category: Nuclear Medicine Source Type: research
“Skull on Fire”: Monostotic Paget Disease of the Skull Bone
An 81-year-old woman was evaluated for a stroke. CT showed no intracranial abnormalities but diffuse patchy aspect of the neurocranium. An MRI and 18F-NA PET/CT were performed to differentiate between metastases, Paget disease, hyperostosis frontalis interna, and primary malignancy. MRI yielded no additional findings. 18F-NA PET/CT showed diffusely increased uptake in the skull and 4 spots with intense uptake. No other suspicious skeletal foci were seen elsewhere. Low-dose CT showed no sign of malignancy elsewhere. Image findings together with elevated serum alkaline phosphatase levels, slightly increased calcium levels, a...
Source: Clinical Nuclear Medicine - December 9, 2020 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Quantifying microcalcification activity in the thoracic aorta
ConclusionsAMA is a simple, rapid and reproducible method of quantifying global18F-NaF uptake across the ascending aorta and aortic arch that correlates with cardiovascular risk scores.
Source: Journal of Nuclear Cardiology - January 20, 2021 Category: Nuclear Medicine Source Type: research
Acute Brain Stroke Evolution Detected by 18F-FDG PET/CT and MRI Justifies the Discordance of Lesions in a Patient With Lymphoproliferative Syndrome
A 50-year-old man with angioimmunoblastic T-cell lymphoma in complete response to treatment presented new hypermetabolic brain lesions on 18F-FDG PET/CT suggestive of malignancy. These findings were correlated by MRI that showed cortical-subcortical peripheral lesions typical of acute ischemic infarction. A restaging 18F-FDG PET/CT showed that hypermetabolic lesions were replaced by ametabolic areas, supporting chronic infarction. Early ischemia presents transitory FDG increase. Brain lymphomas are highly FDG avid and difficult to differentiate from acute cerebral infarction. In view of the discordance of abnormal areas of...
Source: Clinical Nuclear Medicine - February 11, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Multi-scale optoacoustic molecular imaging of brain diseases
We describe outstanding challenges in optoacoustic imaging methodologies and propose a future outlook.
Source: European Journal of Nuclear Medicine and Molecular Imaging - February 16, 2021 Category: Nuclear Medicine Source Type: research
Imaging of the glioma microenvironment by TSPO PET
AbstractGliomas are highly dynamic and heterogeneous tumours of the central nervous system (CNS). They constitute the most common neoplasm of the CNS and the second most common cause of death from intracranial disease after stroke. The advances in detailing the genetic profile of paediatric and adult gliomas along with the progress in MRI and PET multimodal molecular imaging technologies have greatly improved prognostic stratification of patients with glioma and informed on treatment decisions. Amino acid PET has already gained broad clinical application in the study of gliomas. PET imaging targeting the translocator prote...
Source: European Journal of Nuclear Medicine and Molecular Imaging - March 15, 2021 Category: Nuclear Medicine Source Type: research
Crossed cerebellar diaschisis: risk factors and prognostic value in focal cortical dysplasia by 18 F-FDG PET/CT
ConclusionThe number of lobes involved on PET, structural anomalies on MRI, the |AI| values in the posterior frontal and anterior temporal lobes may be predisposing factors for CCD. CCD occurrence may help predict the prognosis of FCD patients at 12 months postoperatively.
Source: Annals of Nuclear Medicine - April 11, 2021 Category: Nuclear Medicine Source Type: research
Automated radiosynthesis and in vivo PET evaluation of VEGFR2 ligand 11CBTFP
Conclusions: [11C]BTFP, a high affinity and selective VEGFR2 ligand amenable for radiolabeling with [11C]isotope, is synthesized and radiolabeled. microPET imaging studies exhibit BBB penetration and retention of [11C]BTFP in mice brain. The details of radiosynthesis and imaging experiments will be presented. References: (1) Shim, J.W.; Madsen, J.R. VEGF Signaling in Neurological Disorders. Int. J. Mol. Sci. 2018, 19(1): 275. (2) Apte RS, Chen DS, Ferrara N. VEGF in Signaling and Disease: Beyond Discovery and Development. Cell. 2019, 176(6):1248.
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Neelamegam, R., Kumar, D. Tags: Automation & amp; Technology Development Source Type: research
Two-year change in 18F-sodium fluoride uptake in the carotid arteries of healthy subjects and angina pectoris patients
Conclusions: Slightly higher NaF uptake in the angina group indicated more ongoing carotid microcalcification at both time points in patients than in healthy subjects. The 2-year changes were very small in both groups, albeit with a tendency of slight decreases among healthy controls, suggesting a more dynamic, waxing and waning, process in these compared to a slow, but more consistent, progression in angina patients despite statin therapy in half of these.
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Piri, R., Lici, G., Riyahimanesh, P., Gerke, O., Alavi, A., Flemming Hoilund-Carlsen, P. Tags: Clinical Science Source Type: research
Brain-related complications of COVID-19 and the role of FDG-PET in detecting vascular and non-vascular defects throughout the body
Conclusions FDG-PET can characterize the extent of systemic disease in COVID-19 patients and provide value in the early identification of complications that may make patients more susceptible to the harmful respiratory and systemic side effects of COVID-19. Severe neurological ramifications of COVID-19 have been noted such as the increased prevalence of acute cerebrovascular incidents. In these contexts, emerging literature has proven that the use of FDG-PET can be useful in monitoring the neurological manifestations the COVID-19 virus.
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Rigney, G., Ayubcha, C., Werner, T., Revheim, M.-E., Alavi, A. Tags: Neurosciences Source Type: research
Hemiplegic migraine episode triggered by regadenoson
AbstractSPECT and PET myocardial perfusion imaging (MPI) are widely used to evaluate patients for coronary artery disease. Regadenoson (a selective A2A adenosine receptor agonist) is a commonly used vasodilator agent for stress MPI because of its safety profile and ease of use. Common adverse reactions such as headache, shortness of breath, flushing, and chest and abdominal discomfort are typically mild and can be effectively reversed using methylxanthines such as aminophylline and caffeine. Neurological adverse reactions such as seizure and stroke have rarely been reported with the use of regadenoson. The hemodynamic chan...
Source: Journal of Nuclear Cardiology - July 25, 2021 Category: Nuclear Medicine Source Type: research
SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture
ConclusionCalcification imaging alone can only accurately identify highly calcified, stable, fibrocalcific plaques. To identify high-risk plaques, with little or no calcification, hybrid imaging of calcification and inflammation could provide diagnostic benefit.
Source: Journal of Nuclear Cardiology - July 27, 2021 Category: Nuclear Medicine Source Type: research
Role of sex hormones in modulating myocardial perfusion and coronary flow reserve
ConclusionOur experimental data in mice indicate that sex differences in myocardial perfusion are primarily driven by testosterone. Given the diagnostic importance of PET-MPI in clinical routine, further studies are warranted to determine whether testosterone levels affect the interpretation of myocardial perfusion findings in patients.
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 13, 2022 Category: Nuclear Medicine Source Type: research
60 Years of Achievements by KSNM in Neuroimaging Research
AbstractNuclear medicine neuroimaging is able to show functional and molecular biologic abnormalities in various neuropsychiatric diseases. Therefore, it has played important roles in the clinical diagnosis and in research on the normal and pathological states of the brain. More than 400 outstanding studies have been conducted by Korean researchers over the past 60 years. In the 1990s, when multiheaded single-photon emission computed tomography (SPECT) scanners were first introduced in South Korea, stroke research using brain perfusion SPECT was conducted. With the spread of positron emission tomography (PET) scanners in...
Source: Nuclear Medicine and Molecular Imaging - January 15, 2022 Category: Nuclear Medicine Source Type: research
