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Vaccination: Vaccines

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Total 28 results found since Jan 2013.

Thrombocytopenia with acute ischemic stroke and bleeding in a patient newly vaccinated with an adenoviral vector-based COVID-19 vaccine
We describe the first Danish case of presumed inflammatory and thrombotic response to vaccination with an adenoviral (ChAdOx1) vector based COVID-19 vaccine (AZD1222). The case describes a 60-year old woman, who was admitted with intractable abdominal pain seven days after receiving the vaccine. Computer Tomography (CT) of the abdomen revealed bilateral adrenal hemorrhages. On the following day she developed a massive right sided ischemic stroke and Magnetic Resonance Imaging (MRI) angiography showed occlusion of the right internal carotid artery. The ischemic area was deemed too large to offer reperfusion therapy. During ...
Source: Thrombosis and Haemostasis - April 20, 2021 Category: Hematology Authors: Rolf Ankerlund Blauenfeldt S øren Risom Kristensen Siw Leiknes Ernstsen Claudia Christina Hilt Kristensen Claus Ziegler Simonsen Anne-Mette Hvas Source Type: research

Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis.
This study investigated whether anti-GluN1-mediated neuroprotection involves inhibition of platelet function. Four commercial anti-GluN1 antibodies were screened for their abilities to inhibit human platelet aggregation. Haematological parameters were examined in rats vaccinated with GluN1. Platelet effects of a mouse monoclonal antibody targeting the glycine-binding region of GluN1 (GluN1-S2) were tested in assays of platelet activation, aggregation and thrombus formation. The epitope of anti-GluN1-S2 was mapped and the mechanism of antibody action modelled using crystal structures of GluN1. Our work found that rats vacci...
Source: Platelets - March 11, 2017 Category: Hematology Tags: Platelets Source Type: research

New Paradigms in Sepsis: From Prevention to Protection of Failing Microcirculation
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - July 1, 2015 Category: Hematology Authors: J. Hawiger, R. A Veach, J. Zienkiewicz Tags: Review Article Source Type: research

New Paradigms in Sepsis: From Prevention to Protection of Failing Microcirculation.
This article is protected by copyright. All rights reserved. PMID: 26190521 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - July 18, 2015 Category: Hematology Authors: Hawiger J, Veach RA, Zienkiewicz J Tags: J Thromb Haemost Source Type: research

Complications of sickle cell anaemia in children in Northwestern Tanzania.
Conclusion Children with SCA receiving care in Tanzania are diagnosed late, hospitalized frequently, and have severe complications. Opportunities exist to improve care through wider access to screening and diagnosis as well as better coordination of comprehensive care. PMID: 26868490 [PubMed - as supplied by publisher]
Source: Hematology - February 14, 2016 Category: Hematology Tags: Hematology Source Type: research

Developing new pharmacotherapeutic approaches to treating sickle ‐cell disease
Survival for patients with SCD has been prolonged by improvements in supportive care, including vaccinations, antibiotic prophylaxis and overall medical management, including transfusion. However, there remains only one approved, partially effective drug for sickle‐cell disease—hydroxyurea (hydroxycarbamide). The world desperately needs better ways of both treating and preventing the recurrent painful vaso‐occlusive episodes pathognomonic of sickle‐cell disease as well as the end‐organ damage that still leads inexorably to severely shortened life expectancies throughout the world. Based on accumulating knowledge ...
Source: ISBT Science Series - July 31, 2016 Category: Hematology Authors: M. J. Telen Tags: Congress Review Source Type: research

Sickle cell disease: Transslating clinical care to low-resource countries through international research collaborations
The vast majority of the world ′s population of children and adults with sickle cell disease (SCD) are born in low-resource settings, particularly in sub-Saharan Africa, the Caribbean, the Middle East, and India. As a result numerous well-established, cost-effective, and evidence-based strategies for managing SCD such as newbor n screening, early education, vaccinations, screening for stroke prevention, and treatments with safe transfusions and hydroxyurea are often unavailable, leading to substantial morbidity and increased mortality.
Source: Seminars in Hematology - April 25, 2018 Category: Hematology Authors: Luke R. Smart, Arielle G. Hernandez, Russell E. Ware Source Type: research

Sickle cell disease: Translating clinical care to low-resource countries through international research collaborations
The vast majority of the world ’s population of children and adults with sickle cell disease (SCD) are born in low-resource settings, particularly in sub-Saharan Africa, the Caribbean, the Middle East, and India. As a result numerous well-established, cost-effective, and evidence-based strategies for managing SCD such as newbor n screening, early education, vaccinations, screening for stroke prevention, and treatments with safe transfusions and hydroxyurea are often unavailable, leading to substantial morbidity and increased mortality.
Source: Seminars in Hematology - April 25, 2018 Category: Hematology Authors: Luke R. Smart, Arielle G. Hernandez, Russell E. Ware Tags: Review article Source Type: research

Quality of Care Indicators in Patients with Sickle Cell Disease (SCD): Influenza Vaccination and Routine Eye Examination Are Associated with Outpatient Utilization but Not Acute Hospital Care, Whereas Comorbidity Indexes Are Strongly Associated with Both
In conclusion, outpatient-based candidate quality indicators of care examined (influenza vaccination and eye examination), were associated with increased outpatient utilization, but not acute visits or hospitalizations. Co-morbidity indexes have significant confounding effects on outpatient and hospital utilization. Administrative data based quality indicators of care such as influenza vaccination, as well as SCD specific comorbidity indexes warrant further studies as these may help better understand optimal allocation of health care resources for patients with SCD.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Adamkiewicz, T., Baltrus, P., Li, C., Carter-Wicker, K., Gaglioti, A. Tags: 903. Outcomes Research-Non-Malignant Hematology: Poster II Source Type: research

Home Based Primary Care for Patients with Sickle Cell Disease
Conclusion: Overall, home based primary care seems to be a promising alternative for pts with SCD. It had a significant impact on patient quality of care and may improve prescription adherence, but more data are needed to determine if it has an effect on healthcare utilization for pts with SCD.DisclosuresMoore: Ohio State University College of Medicine: Research Funding. Desai: FDA: Research Funding; Pfizer: Research Funding; University of Pittsburgh: Research Funding; Selexy/Novartis: Research Funding; NIH: Research Funding; Ironwood: Other: Adjudication Committee.
Source: Blood - November 21, 2018 Category: Hematology Authors: Moore, M. D., Schamess, A., Williams, N., Huang, Y., Menka, G., Desai, P. C. Tags: 901. Health Services Research-Non-Malignant Conditions: Poster III Source Type: research

Systematic review/meta-analysis on efficacy of allogeneic HCT in sickle cell disease: an international effort on behalf of the Pediatric Diseases Working Party of EBMT and the Sickle Cell Transplantation International Consortium
Sickle cell disease (SCD) is the most common inherited hemoglobinopathy affecting nearly 100,000 individuals in the United States and approximately 300,000 worldwide, with low-income countries bearing the highest burden.1, 2 It is associated with several complications including debilitating morbidity, organ injury, and shortened life expectancy. Progress have been made in recent years to the overall management of SCD, namely improved health maintenance surveillance programs, penicillin prophylaxis, chronic blood transfusions, vaccines, primary and secondary stroke prophylaxis, use of hydroxyurea and approval of novel agent...
Source: Biology of Blood and Marrow Transplantation - December 10, 2020 Category: Hematology Authors: Madiha Iqbal, Tea Reljic, Selim Corbacioglu, Josu de la Fuente, Eliane Gluckman, Ambuj Kumar, Farah Yassine, Ernesto Ayala, Areej El-Jawahri, Hemant Murthy, Fahad Almohareb, Shahrukh K. Hashmi, Barbara Cappelli, Ali Alahmari, Graziana Maria Scigliuolo, Ad Source Type: research

Systematic Review/Meta-Analysis on Efficacy of Allogeneic Hematopoietic Cell Transplantation in Sickle Cell Disease: An International Effort on Behalf of the Pediatric Diseases Working Party of European Society for Blood and Marrow Transplantation and the Sickle Cell Transplantation International Consortium
Sickle cell disease (SCD) is the most common inherited hemoglobinopathy, affecting nearly 100,000 individuals in the United States and approximately 300,000 worldwide, with low-income countries bearing the highest burden [1,2]. It is associated with several complications, including debilitating morbidity, organ injury, and shortened life expectancy. Progress in the overall management of SCD has been made in recent years, namely improved health maintenance surveillance programs, penicillin prophylaxis, chronic blood transfusions, vaccines, primary and secondary stroke prophylaxis, use of hydroxyurea, and approval of novel a...
Source: Biology of Blood and Marrow Transplantation - December 10, 2020 Category: Hematology Authors: Madiha Iqbal, Tea Reljic, Selim Corbacioglu, Josu de la Fuente, Eliane Gluckman, Ambuj Kumar, Farah Yassine, Ernesto Ayala, Areej El-Jawahri, Hemant Murthy, Fahad Almohareb, Shahrukh K. Hashmi, Barbara Cappelli, Ali Alahmari, Graziana Maria Scigliuolo, Ad Source Type: research

Suggested treatment of serious complications to Covid-19 vaccination with IdeS, a bacterial antibody-cleaving enzyme
J Thromb Haemost. 2021 Jun 24. doi: 10.1111/jth.15433. Online ahead of print.ABSTRACTSeveral recent reports have independently described a rare thrombosis with thrombocytopenia syndrome (TTS) post vaccination with ChAdOx1 nCoV-19. In J. Thromb. Haemost., Ankerlund Blauenfeldt et al. [1] described the clinical presentation of a case of fatal acute ischemic stroke associated with profound thrombocytopenia. The pathogenesis behind this case may involve mechanisms similarly to autoimmune heparin-induced thrombocytopenia (HIT) since anti-platelet factor 4(PF-4) antibodies were detected in the patient plasma.PMID:34165239 | DOI:10.1111/jth.15433
Source: Thrombosis and Haemostasis - June 24, 2021 Category: Hematology Authors: Fredrik Kahn Oonagh Shannon Lars Bj örck Source Type: research