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Factors associated with stroke formation in blunt cerebrovascular injury: An EAST multicenter study
BACKGROUND Stroke risk factors after blunt cerebrovascular injury (BCVI) are ill-defined. We hypothesized that factors associated with stroke for BCVI would include medical therapy (i.e., Aspirin), radiographic features, and protocolization of care. METHODS An Eastern Association for the Surgery of Trauma–sponsored, 16-center, prospective, observational trial was undertaken. Stroke risk factors were analyzed individually for vertebral artery (VA) and internal carotid artery (ICA) BCVI. Blunt cerebrovascular injuries were graded on the standard 1 to 5 scale. Data were from the initial hospitalization only. R...
Source: The Journal of Trauma: Injury, Infection, and Critical Care - February 1, 2022 Category: Orthopaedics Tags: 2021 EAST PODIUM PAPERS Source Type: research

Influence of luminal stenosis in aneurysmal and non-aneurysmal blunt cerebrovascular injury
In high grade blunt cerebrovascular injury (BCVI), rates of stroke can be substantial with stroke frequently responsible for patient mortality [1,2]. Pharmacologic therapy with antiplatelet agents or anticoagulation and early BCVI diagnosis decrease stroke rates [3 –5]. Focus is placed on rapid screening and initiation of pharmacologic therapy to prevent strokes. Pharmacologic and endovascular BCVI treatment are chosen based on BCVI grade, which stratifies BCVI from 1-5 based on radiographic characteristics [6].
Source: Injury - November 3, 2018 Category: Orthopaedics Authors: Margaret H. Lauerman, Karen Irizarry, Clint Sliker, Brandon R. Bruns, Ronald Tesoriero, Thomas M. Scalea, Deborah M. Stein Source Type: research

Fixation of acetabular Fractures. a novel method of Pre-Operative Omega Plate contouring.
CONCLUSIONS Pre-operative contouring of an Omega plate based on a post-injury CT scan of the uninjured half of the pelvis is over 80% accurate or almost accurate. The multi-functional 3.5-mm pelvic plate Omega allows us to stabilise complicated fractures of the superior ramus of the pubic bone, anterior acetabular column or quadrilateral plate as well as fractures above the linea arcuata or uncomplicated fractures of the posterior column. The stabilisation of all fragments of the anterior column and quadrilateral plate is very firm and the Omega plate is resistant to fragment redisplacement. Also, it is its advantage that ...
Source: Acta Orthopaedica - June 23, 2014 Category: Orthopaedics Authors: Taller S, Srám J, Lukáš R, Endrych L, Džupa V Tags: Acta Chir Orthop Traumatol Cech Source Type: research

Rheumatoid Arthritis–Induced Lateral Atlantoaxial Subluxation With Multiple Vertebrobasilar Infarctions
Conclusion. In patients with RA, the potential risk of AAS should be recognized. Lateral AAS in particular may induce cerebral ischemia by positional VA occlusion in advanced stages of the disease. Level of Evidence: N/A
Source: Spine - January 31, 2015 Category: Orthopaedics Tags: Case Report Source Type: research

Abdominal aortic calcification: a reappraisal of epidemiological and pathophysiological data
In men and women, there is a significant association between the risk of cardiovascular event (myocardial infarction, stroke) and risk of major fragility fracture (hip, vertebra). Abdominal aortic calcification (AAC) can be assessed using semiquantitative scores on spine radiographs and spine scans obtained by DXA. Severe AAC is associated with higher risk of major cardiovascular event. Not only does severe AAC reflect poor cardiovascular health status, but also directly disturbs blood flow in the vascular system.
Source: Bone - December 10, 2015 Category: Orthopaedics Authors: Pawel Szulc Tags: Review Source Type: research

Duplex Ultrasonography-Detected Positional Vertebral Artery Occlusion in Upper Cervical Rheumatoid Arthritis
Study Design. Prospective imaging study. Objective. To clarify the frequency of positional vertebral artery (VA) occlusion using duplex ultrasonography in patients with rheumatoid arthritis (RA). Summary of Background Data. Some patients with upper cervical RA develop thromboembolic stroke related to positional and transient VA occlusions; however, whether RA patients have positional VA occlusion without neurological symptoms is unclear. Methods. Outpatients with RA were enrolled. Clinical data were collected, and radiograph examinations were performed to measure the anterior atlantodental interval (AADI), the posterior at...
Source: Spine - December 21, 2015 Category: Orthopaedics Tags: Cervical Spine Source Type: research

Serum levels of Dkk-1, sclerostin and VEGF in patients with ankylosing spondylitis and their association with smoking, and clinical, inflammatory and radiographic parameters
Conclusion In AS, serum Dkk-1 concentrations appear to be related not only to syndesmophyte formation but also to systemic inflammation. Furthermore, high VEGF levels may be associated with smoking exposure.
Source: Joint Bone Spine - August 12, 2016 Category: Orthopaedics Source Type: research

Perioperative Neurologic Complications in Adult Spinal Deformity Surgery: Incidence and Risk Factors in 564 Patients
Conclusion. The overall incidence of neurologic complications in ASD surgery was 17.6%. The incidence of surgical neurologic complications was 13.7%. There was a higher risk of neurologic complications in revision cases and in cases in which interbody fusion was required. Level of Evidence: 3
Source: Spine - March 15, 2017 Category: Orthopaedics Tags: Deformity Source Type: research

Neurologic Comorbidities Predict Proximal Junctional Failure in Adult Spinal Deformity
ConclusionsIn this study, risk factors identified for the development of PJF included nonmechanical neurologic comorbidities, emphasizing the need to look beyond radiographic alignment in order to reduce the incidence of PJF.Level of EvidenceLevel 3.
Source: Spine Deformity - August 16, 2018 Category: Orthopaedics Source Type: research

Tibialis posterior transfer for foot drop due to central causes: Long-term hindfoot alignment
DiscussionIn contrast to the working hypothesis, we found no evidence of progression to valgus flatfoot after TPT transfer performed to treat central foot drop.Level of evidenceIV, retrospective study with no control group.
Source: Orthopaedics and Traumatology: Surgery and Research - December 25, 2018 Category: Orthopaedics Source Type: research

Effect of clopidogrel in bone healing-experimental study in rabbits.
CONCLUSION: Our results indicate that maintenance of perioperative clopidogrel treatment does not negatively affect bone healing but rather promotes it. Further research is needed in order to find useful applications of this finding. PMID: 31908992 [PubMed]
Source: World Journal of Orthopaedics - January 9, 2020 Category: Orthopaedics Tags: World J Orthop Source Type: research

Safety of early posterior fusion surgery without endovascular embolization for asymptomatic vertebral artery occlusion associated with cervical spine trauma
ConclusionDespite the lack of a concurrent control group with preoperative antiplatelet therapy or endovascular embolization for VAO, our results showed low symptomatic stroke rate (4.5%), high recanalization rate (40.9%), and low mortality rate (0%). Therefore, we believe that the indication for early stabilization surgery as management strategy of asymptomatic VAO might be one of the safe and effective treatment options for prevention of symptomatic cerebral infarction.
Source: European Spine Journal - July 12, 2022 Category: Orthopaedics Source Type: research

Sickle cell bone disease and response to intravenous bisphosphonates in children
ConclusionChildren with SCD have the potential for extensive and early-onset bone morbidity. In this series, IV bisphosphonates were effective for bone pain analgesia and did not trigger sickle cell complications.
Source: Osteoporosis International - July 29, 2022 Category: Orthopaedics Source Type: research