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Specialty: Gastroenterology

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Total 421 results found since Jan 2013.

Drug-Drug Interactions in Hepatitis Patients: Do these Interactions Matter in Clinical Perspectives?
CONCLUSION: We observed hepatitis patients presented with a considerable number of clinically relevant pDDIs. Attention should be given to widespread major-pDDIs and their potential adverse outcomes. Clinically relevant parameters, such as labs and signs/symptoms should be monitored particularly in high risk patients having polypharmacy, prolong hospitalization, and stroke as comorbidity. PMID: 30600298 [PubMed - in process]
Source: Annals of Hepatology - January 3, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Admission characteristics predictive of in-hospital death from hospital-acquired sepsis: A comparison to community-acquired sepsis
ConclusionsLiver disease and CHF were independent predictors of in-hospital mortality in HA-sepsis. HA-sepsis patients had increased prevalence of previous stroke, myocardial infarction, and liver disease.
Source: Journal of Critical Care - February 20, 2019 Category: Gastroenterology Source Type: research

Drug-Drug Interactions in Hepatitis Patients: Do these Interactions Matter in Clinical Perspectives?
CONCLUSION: We observed hepatitis patients presented with a considerable number of clinically relevant pDDIs. Attention should be given to widespread major-pDDIs and their potential adverse outcomes. Clinically relevant parameters, such as labs and signs/symptoms should be monitored particularly in high risk patients having polypharmacy, prolong hospitalization, and stroke as comorbidity. PMID: 31208626 [PubMed - in process]
Source: Annals of Hepatology - June 20, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Impact of NAFLD on the Incidence of Cardiovascular Diseases in a Primary Care Population in Germany
ConclusionsNAFLD constitutes an independent risk factor for CHD, MI, and AF in primary care in Germany. Identification of patients with NAFLD in primary care will allow specifically managing and modifying underlying risk factors to improve the overall prognosis.
Source: Digestive Diseases and Sciences - December 2, 2019 Category: Gastroenterology Source Type: research

Non-alcoholic fatty liver disease and incident major adverse cardiovascular events: results from a nationwide histology cohort
Conclusion Compared with matched population controls, patients with biopsy-proven NAFLD had significantly higher incidence of MACE, including IHD, stroke, CHF and CV mortality. Excess risk was evident across all stages of NAFLD and increased with worsening disease severity.
Source: Gut - August 11, 2022 Category: Gastroenterology Authors: Simon, T. G., Roelstraete, B., Hagström, H., Sundström, J., Ludvigsson, J. F. Tags: Gut Hepatology Source Type: research

Comparison of bleeding following gastrointestinal endoscopic biopsy in patients treated with and without direct oral anticoagulants
Conclusions The PS analyses showed no significant differences in complications following gastrointestinal endoscopic biopsy between DOAC users and non-users. These results suggest the safety of endoscopic biopsy without DOAC withdrawal although the need for careful hemostasis remains. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: Endoscopy International Open - January 13, 2023 Category: Gastroenterology Authors: Konish, Takaaki Ono, Sachiko Okada, Akira Matsui, Hiroki Tanabe, Masahiko Seto, Yasuyuki Yasunaga, Hideo Tags: Original article Source Type: research

Adverse events requiring hospitalization within 30 days after outpatient screening and nonscreening colonoscopies
Conclusions: This study provides further evidence of the safety of colonoscopy in routine practice with regard to delayed and non-GI AEs. Hospitalizations because of the investigated AEs were uncommon or rare for both screening and nonscreening colonoscopies.
Source: Gastrointestinal Endoscopy - February 15, 2013 Category: Gastroenterology Authors: Christian Stock, Peter Ihle, Andreas Sieg, Ingrid Schubert, Michael Hoffmeister, Hermann Brenner Tags: Clinical Endoscopy Source Type: research

Internal carotid thrombus in patients with inflammatory bowel disease: Two cases.
We report 2 cases of ischemic strokes due to internal carotid thrombus in patients during active phase of IBD. Ulceration of early atherosclerotic plaques activated by a hypercoagulation state may cause a thrombus. A combined therapy with heparin and corticosteroids was used for both our patients. Lysis of the thrombus was obtained after several days without surgical treatment and shown by ultrasonography. These cases highlight an aetiology of stroke in patients with IBD and use of a synergic treatment to respond to hypercoagulability in link with IBD. Benefits and safety of this therapy should be confirmed with clinical s...
Source: World Journal of Gastroenterology : WJG - February 7, 2013 Category: Gastroenterology Authors: Richard S, Mione G, Perrin J, Toussaint-Hacquard M, Lacour JC, Ducrocq X Tags: World J Gastroenterol Source Type: research

Novel oral anticoagulants in gastroenterology practice
Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is associated with a 5-fold increase in the risk of ischemic stroke, and AF-related strokes have worse outcomes than those not associated with AF. Warfarin reduces the risk of stroke in patients with AF by approximately two-thirds and is more effective than aspirin or dual antiplatelet therapy with aspirin and clopidogrel. Although effective, warfarin has limitations that complicate its use. These include unpredictable pharmacokinetics and pharmacodynamics related to genetic polymorphisms and to variations in dietary vitamin K intake and numerous ...
Source: Gastrointestinal Endoscopy - May 31, 2013 Category: Gastroenterology Authors: Jay Desai, Christopher B. Granger, Jeffrey I. Weitz, James Aisenberg Tags: Review Articles Source Type: research

Regional susceptibility to stress-induced intestinal injury in the mouse.
Abstract Injury to the intestinal mucosa is a life-threatening problem in a variety of clinical disorders, including hemorrhagic shock, trauma, burn, pancreatitis and heat stroke. However, the susceptibility to injury of different regions of intestine in these disorders is not well understood. We compared histological injury across the small intestine in two in vivo mouse models of injury, hemorrhagic shock (30% loss of blood volume) and heat stroke (peak core temperature,42.4°C). In both, areas near the duodenum showed significantly greater mucosal injury and reductions in villi height. To determine if these eff...
Source: Am J Physiol Gastroi... - July 18, 2013 Category: Gastroenterology Authors: Novosad VL, Richards JL, Phillips NA, King MA, Clanton TL Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Reduced thoracic fluid content in early-stage primary biliary cirrhosis that associates with impaired cardiac inotropy
This study has confirmed that TFC is reduced in those with PBC, that this is specific to PBC, and that it associates independently with markers of cardiac inotropy.
Source: AJP: Gastrointestinal and Liver Physiology - September 15, 2013 Category: Gastroenterology Authors: Zalewski, P., Jones, D., Lewis, I., Frith, J., Newton, J. L. Tags: CALL FOR PAPERS Source Type: research

Regional susceptibility to stress-induced intestinal injury in the mouse
Injury to the intestinal mucosa is a life-threatening problem in a variety of clinical disorders, including hemorrhagic shock, trauma, burn, pancreatitis, and heat stroke. The susceptibility to injury of different regions of intestine in these disorders is not well understood. We compared histological injury across the small intestine in two in vivo mouse models of injury, hemorrhagic shock (30% loss of blood volume) and heat stroke (peak core temperature 42.4°C). In both injury models, areas near the duodenum showed significantly greater mucosal injury and reductions in villus height. To determine if these effects wer...
Source: AJP: Gastrointestinal and Liver Physiology - September 15, 2013 Category: Gastroenterology Authors: Novosad, V. L., Richards, J. L., Phillips, N. A., King, M. A., Clanton, T. L. Tags: MUCOSAL BIOLOGY Source Type: research

Health systems organization for emergency care
Abstract: The increasing number of acute and severe digestive diseases presenting to hospital emergency departments, mainly related with an ageing population, demands an appropriate answer from health systems organization, taking into account the escalating pressure on cost reduction. However, patients expect and deserve a response that is appropriate, effective, efficient and safe. The huge variety of variables which can influence the evolution of such cases warranting intensive monitoring, and the coordination and optimization of a range of human and technical resources involved in the care of these high-risk patients, r...
Source: Best Practice and Research. Clinical Gastroenterology - October 1, 2013 Category: Gastroenterology Authors: Isabel Pedroto, Pedro Amaro, José Manuel Romãozinho Tags: Chapters Source Type: research

Chronic hepatitis C virus infection and atherosclerosis: Clinical impact and mechanisms.
Abstract Hepatitis C virus (HCV) infection represents a major health issue worldwide due to its burden of chronic liver disease and extrahepatic manifestations including cardiovascular diseases, which are associated with excess mortality. Analysis of published studies supports the view that HCV infection should be considered a risk factor for the development of carotid atherosclerosis, heart failure and stroke. In contrast, findings from studies addressing coronary artery disease and HCV have yielded conflicting results. Therefore, meta-analytic reviews and prospective studies are warranted. The pathogenic mechani...
Source: World Journal of Gastroenterology : WJG - April 7, 2014 Category: Gastroenterology Authors: Adinolfi LE, Zampino R, Restivo L, Lonardo A, Guerrera B, Marrone A, Nascimbeni F, Florio A, Loria P Tags: World J Gastroenterol Source Type: research

When is feeding via a percutaneous endoscopic gastrostomy indicated?
Purpose of review: This review addresses current controversies regarding appropriate indications for percutaneous endoscopic gastrostomy (PEG) insertion. We address specific indications, namely, dementia, stroke, aspiration, motor neurone disease/amyotrophic lateral sclerosis, and head and neck cancer. We recommend practical strategies for improving patient selection. Recent findings: There is now a general consensus in the United States that PEG feeding does not benefit patients with advanced dementia. ‘Early’ PEG insertion following stroke is similarly of no benefit. It is currently unclear whether patients with amyo...
Source: Current Opinion in Gastroenterology - February 6, 2015 Category: Gastroenterology Tags: NUTRITION: Edited by Eamonn M.M. Quigley Source Type: research