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Specialty: Cardiology
Nutrition: Iron

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Total 27 results found since Jan 2013.

Rationale and Current Evidence for Testing Iron Chelators for Treating Stroke
AbstractPurpose of ReviewTo discuss the mechanisms of iron regulation in the brain and the pathophysiological role of deregulation of iron homeostasis following a stroke, and to review existing evidence supporting the potential role of iron chelators in the treatment of ischemic and hemorrhagic stroke.Recent FindingsIn recent years, accumulating evidence has highlighted the role of neuroinflammation in neurological injury after ischemic and hemorrhagic stroke, and that free iron is central to this process. Via the Fenton reaction, free iron catalyzes the conversion of superoxide ion and hydrogen peroxide into hydroxyl radi...
Source: Current Cardiology Reports - March 3, 2019 Category: Cardiology Source Type: research

Iron-Deficiency and Estrogen Are Associated with Ischemic Stroke by Up-Regulating Transferrin to Induce Hypercoagulability.
Conclusions: Our findings revealed that certain factors (i.e., ID and CC) up-regulating transferrin are risk factors of thromboembolic diseases decipher a previously unrecognized mechanistic association among ID, CC and IS and provide a novel strategy for the development of anti-IS medicine by interfering with transferrin-thrombin/FXIIa interactions. PMID: 32450779 [PubMed - as supplied by publisher]
Source: Circulation Research - May 25, 2020 Category: Cardiology Authors: Tang X, Fang M, Cheng R, Zhang Z, Wang Y, Shen C, Han Y, Lu Q, Du Y, Liu Y, Sun Z, Zhu L, Mwangi J, Xue M, Long C, Lai R Tags: Circ Res Source Type: research

B-po03-151 left atrial appendage occlusion as alternative approach for stroke prevention in hereditary hemorrhagic telangiectasia patients with atrial fibrillation
In this study, we evaluate the safety and efficacy of left atrial appendage occlusion (LAAO) for stroke prevention in HHT.
Source: Heart Rhythm - July 28, 2021 Category: Cardiology Authors: Mohammed Alghammass, Jad Aldanaf, Elizabeth Dranow, Kevin Whitehead Source Type: research

Laboratory Grown Biofilms of Bacteria Associated with Human Atherosclerotic Carotid Arteries Release Collagenases and Gelatinases during Iron-Induced Dispersion
This study shows that plaque-associated bacteria, when cultured as mixed-species biofilms in the laboratory, can release degradative enzymes into their environment as the result of a dispersion response triggered by iron. These degradative enzymes can digest proteins and lipids which are associated with the tissues that separate the plaque lesion from the arterial lumen. Thus, this study demonstrates that if mixed species biofilms are induced to undergo dispersion in an infected atherosclerotic lesion when exposed to an elevated concentration of free iron, they have the potential to contribute to the weakening of arterial ...
Source: Atherosclerosis - May 11, 2022 Category: Cardiology Authors: Amanda M Zdimal David G Davies Source Type: research

Glutamine synthetase in human carotid plaque macrophages associates with features of plaque vulnerability: An immunohistological study
CONCLUSIONS: Our results link connect macrophage GLUL expression with carotid plaque features characterizing plaque vulnerability.PMID:35667160 | DOI:10.1016/j.atherosclerosis.2022.05.008
Source: Atherosclerosis - June 6, 2022 Category: Cardiology Authors: Pia Sorto Mikko I M äyränpää Jani Saksi Krista Nuotio Petra Ij äs Jarno Tuimala Pirkka Vikatmaa Lauri Soinne Petri T Kovanen Perttu J Lindsberg Source Type: research

Development of Molecular Magnetic Resonance Imaging Tools for Longitudinal Tracking of Carotid Atherosclerotic Disease Using Fast Imaging with Steady-State Precession
Transl Stroke Res. 2022 Jul 18. doi: 10.1007/s12975-022-01067-8. Online ahead of print.ABSTRACTIdentification of patients with high-risk asymptomatic carotid plaques remains a challenging but essential step in stroke prevention. Current selection criteria for intervention in carotid disease are still determined by symptomatology and degree of luminal stenosis. This strategy has been less effective in identifying the high-risk asymptomatic individual patients. Inflammation is the key factor that drives plaque instability causing clinical sequelae. Currently, there is no imaging tool in routine clinical practice to assess th...
Source: Atherosclerosis - July 20, 2022 Category: Cardiology Authors: Sung-Jin Park Wan Ying Chan Michael Ng Yiu Cho Chung Tze Tec Chong Kishore Bhakoo Joyce M S Chan Source Type: research

Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment
The objective of this study is to explore the current literature supporting the use oral multivitamins and multi/minerals (OMVMs) for cardiovascular diseases (CVD) treatment and prevention.Recent FindingsData on multivitamins, vitamin C and D, coenzyme Q, calcium, and selenium, has showed no consistent benefit for the prevention of CVD, myocardial infarction, or stroke, nor was there a benefit for all-cause mortality to support their routine supplementation. Folic acid alone and B vitamins with folic acid, B6 and B12, reduce stroke, whereas niacin and antioxidants are associated with an increased risk of all-cause mortalit...
Source: Current Cardiology Reports - February 13, 2020 Category: Cardiology Source Type: research

Safety and efficacy of iron supplementation after myocardial infarction in mice with moderate blood loss anaemia
ConclusionsIron supplementation 24  h after reperfusion of AMI is safe and reversed enlargement of end-systolic volume after AMI resulting in increased stroke volume and cardiac output. This highlights its potential as adjunctive treatment in anaemia with ID after reperfused AMI. Time point of iron application after reperfusion appe ars critical.
Source: ESC Heart Failure - October 12, 2021 Category: Cardiology Authors: Patricia Wischmann, Ramesh Chennupati, Isabella Solga, Felix Funk, Stefanie Becher, Norbert Gerdes, Stefan Anker, Malte Kelm, Christian Jung Tags: Original Research Article Source Type: research

Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions
Circ Res. 2022 Apr 15;130(8):1204-1229. doi: 10.1161/CIRCRESAHA.121.319949. Epub 2022 Apr 14.ABSTRACTIntracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity and mortality. This review article focuses on the epidemiology, cause, mechanisms of injury, current treatment strategies, and future research directions of ICH. Incidence of hemorrhagic stroke has increased worldwide over the past 40 years, with shifts in the cause over time as hypertension management has improved and anticoagulant use has increased. Preclinical and clinical trials have elucidated the underlying ICH cause and mechanisms of i...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Jessica Magid-Bernstein Romuald Girard Sean Polster Abhinav Srinath Sharbel Romanos Issam A Awad Lauren H Sansing Source Type: research

Heme iron intake and acute myocardial infarction: A prospective study of men
Conclusions: Findings from this prospective study indicate that a high heme iron intake, particularly with simultaneous low intake of minerals that can decrease iron absorption, may increase the risk of fatal AMI.
Source: International Journal of Cardiology - January 22, 2014 Category: Cardiology Authors: Joanna Kaluza, Susanna C. Larsson, Niclas Håkansson, Alicja Wolk Tags: Original Articles Source Type: research

Anemia in Heart Failure
Publication date: Available online 8 November 2017 Source:JACC: Heart Failure Author(s): Niels Grote Beverborg, Dirk J. van Veldhuisen, Peter van der Meer One-third of all patients with heart failure have anemia, and its presence is associated with more symptoms, increased rates of hospitalization, and mortality. The etiology of anemia is multifactorial, complex, and varies between patients. The most important factors leading to anemia in heart failure are inadequate erythropoietin production resulting from renal failure, intrinsic bone marrow defects, medication use, and nutritional deficiencies such as iron deficiency. ...
Source: JACC: Heart Failure - November 19, 2017 Category: Cardiology Source Type: research

Influence of dietary iron intake restriction on the development of hypertension in weanling prehypertensive rats
AbstractHypertension is a major public health problem leading to death. To reduce the morbidity and mortality in patients with hypertension, it is crucial to develop a novel strategy for prevention of hypertension. We have currently reported an attempt at dietary iron intake restriction as non-pharmacological treatment of hypertension in patients with hypertension. However, it remains fully unknown whether dietary iron restriction prevents the development of hypertension. We investigated the influence of dietary iron restriction on the development of hypertension in weanling pre-hypertensive model rats. 3-week-old male str...
Source: Heart and Vessels - February 7, 2018 Category: Cardiology Source Type: research