Filtered By:
Specialty: Neurology
Nutrition: Iron
This page shows you your search results in order of relevance.
Order by Relevance | Date
Total 75 results found since Jan 2013.
Deferoxamine Treatment Prevents Post-Stroke Vasoregression and Neurovascular Unit Remodeling Leading to Improved Functional Outcomes in Type 2 Male Diabetic Rats: Role of Endothelial Ferroptosis
This study aimed to determine the impact of iron chelation with deferoxamine (DFX) on (1) cerebral vascularization patterns and (2) functional outcomes after stroke in control and diabetic rats. After 8 weeks of type 2 diabetes induced by a combination of high-fat diet and low-dose streptozotocin, male control and diabetic animals were subjected to thromboembolic middle cerebral artery occlusion (MCAO) and randomized to vehicle, DFX, or tPA/DFX and followed for 14 days with behavioral tests. Vas cular indices (vascular volume and surface area), neurovascular remodeling (AQP4 polarity), and microglia activation were meas...
Source: Translational Stroke Research - August 31, 2020 Category: Neurology Source Type: research
Certain types of iron oxide nanoparticles are not suited to passively target inflammatory cells that infiltrate the brain in response to stroke
as Endres, Ulrich Dirnagl
& Tracy D Farr
Source: Journal of Cerebral Blood Flow - February 27, 2013 Category: Neurology Authors: Christoph HarmsAnna Lena DatwylerFrank WiekhorstLutz TrahmsRandall LindquistEyk SchellenbergerSusanne MuellerGunnar SchützFarnoosh RoohiAndreas IdeMartina FüchtemeierKaren GertzGolo KronenbergUlrike HarmsMatthias EndresUlrich DirnaglTracy D Farr Tags: inflammation iron oxide nanoparticles magnetic resonance imaging stroke Source Type: research
Association of Ferroptosis with Severity and Outcomes in Acute Ischemic Stroke Patients Undergoing Endovascular Thrombectomy: A Case-control Study
AbstractFerroptosis, an iron-dependent form of cell death, is characterized by intracellular accumulation of iron and reactive oxygen species-induced lipid peroxidation. Animal experiments have shown the important roles of ferroptosis in ischemic stroke, but the evidence in human stroke is insufficient. This prospective study evaluated the associations between plasma ferroptosis biomarkers at hyperacute stage and long-term outcomes in patients with acute ischemic stroke undergoing endovascular thrombectomy (EVT). The plasma samples were collected immediately before and after EVT (T1 and T2) and at 24 h (T3) for the 126 s...
Source: Molecular Neurobiology - September 1, 2023 Category: Neurology Source Type: research
Role of lipocalin 2 in stroke
Neurobiol Dis. 2023 Feb 16:106044. doi: 10.1016/j.nbd.2023.106044. Online ahead of print.ABSTRACTStroke is the second leading cause of death worldwide; however, the treatment choices available to neurologists are limited in clinical practice. Lipocalin 2 (LCN2) is a secreted protein, belonging to the lipocalin superfamily, with multiple biological functions in mediating innate immune response, inflammatory response, iron-homeostasis, cell migration and differentiation, energy metabolism, and other processes in the body. LCN2 is expressed at low levels in the brain under normal physiological conditions, but its expression i...
Source: Neurobiology of Disease - February 22, 2023 Category: Neurology Authors: Ruo-Yu Zhao Peng-Ju Wei Xin Sun Dian-Hui Zhang Qian-Yan He Jie Liu Jun-Lei Chang Yi Yang Zhen-Ni Guo Source Type: research
Inhibition of Toll-Like Receptor-4 (TLR-4) Improves Neurobehavioral Outcomes After Acute Ischemic Stroke in Diabetic Rats: Possible Role of Vascular Endothelial TLR-4
In conclusion, TLR-4 is highly upregulated in the microvasculature and that beneficial effects of TLR-4 inhibition are more profound in diabetes. This suggests that inhibition of vascular TLR-4 may provide therapeutic benefits for stroke recovery in diabetes.
Source: Molecular Neurobiology - February 27, 2019 Category: Neurology Source Type: research
Iron Measured in Nasal Exudate Samples as a New and Useful Biomarker in the Differential Diagnosis of Patients with Acute Stroke
Conclusions: Our findings suggest that iron levels in nasal exudate may be useful in the acute stage for the differential diagnosis between ischemic and hemorrhagic damage in acute stroke patients. They also open a potential field to study other biomarkers in nasal exudate in several neurological disorders. Clinical studies must be performed to confirm our results.Cerebrovasc Dis
Source: Cerebrovascular Diseases - November 20, 2020 Category: Neurology Source Type: research
Ferroptosis —A Novel Mechanism With Multifaceted Actions on Stroke
As a neurological disease with high morbidity, disability, and mortality, the pathological mechanism underlying stroke involves complex processes such as neuroinflammation, oxidative stress, apoptosis, autophagy, and excitotoxicity; but the related research on these molecular mechanisms has not been effectively applied in clinical practice. As a form of iron-dependent regulated cell death, ferroptosis was first discovered in the pathological process of cancer, but recent studies have shown that ferroptosis is closely related to the onset and development of stroke. Therefore, a deeper understanding of the relationship betwe...
Source: Frontiers in Neurology - April 11, 2022 Category: Neurology Source Type: research
Cottonseed oil alleviates ischemic stroke injury by inhibiting ferroptosis
ConclusionCSO treatment can alleviate ischemic stroke injury via ferroptosis inhibition, which provides a new potential therapeutic mechanism for CSO neuroprotection against ischemic stroke.
Source: Brain and Behavior - July 22, 2023 Category: Neurology Authors: Miao Sun,
Min Liu,
Qingxiao Li,
Xiaoying Zhang,
Siyuan Liu,
Huikai Yang,
Le Yang,
Jiahe Tian,
Weidong Mi,
Yulong Ma Tags: ORIGINAL ARTICLE Source Type: research
Susceptibility-weighted imaging predicts infarct size and early-stage clinical prognosis in acute ischemic stroke
AbstractSusceptibility-weighted imaging (SWI) is a non-invasive technique that can reveal venous structures and iron in the brain. This retrospective study evaluated SWI, relative to other imaging techniques, for determining cerebral infarct size and early-stage clinical prognosis in patients with acute ischemic stroke. Within 3 days after onset, 22 patients with acute ischemic stroke underwent SWI, diffusion-weighted imaging (DWI), perfusion-weighted imaging (PWI), fluid-attenuated inversion recovery (FLAIR), and magnetic resonance angiography (MRA). At least 7 days after onset, the patients also underwent cranial FLAI...
Source: Neurological Sciences - March 20, 2018 Category: Neurology Source Type: research
Infantile Basal Ganglia Stroke after Mild Head Trauma Associated with Mineralizing Angiopathy of Lenticulostriate Arteries: An Under Recognized Entity
We describe five young (7–13 months old on presentation) male children who suffered from hemiparesis due to ischemic stroke of the basal ganglia, four of them after minor head trauma. All of them had calcification in the basal ganglia visible on computed tomography or cranial ultrasound but not on magnetic resonance imaging. Follow-up care was remarkable for recurrent infarction in three patients. One patient had a second symptomatic stroke on the contralateral side, and two patients showed new asymptomatic infarctions in the contralateral basal ganglia on imaging. In view of the scant literature, this clinic-radiologic ...
Source: Neuropediatrics - May 23, 2018 Category: Neurology Authors: Toelle, Sandra P. Avetisyan, Tamara Kuyumjyan, Nune Sukhudyan, Biayna Boltshauser, Eugen Hackenberg, Annette Tags: Original Article Source Type: research
SATB1/SLC7A11/HO-1 Axis Ameliorates Ferroptosis in Neuron Cells After Ischemic Stroke by Danhong Injection
AbstractNeuronal damage after ischemic stroke (IS) is frequently due to ferroptosis, contributing significantly to ischemic injury. However, the mechanism against ferroptosis in IS remained unclear. The aim of this study was to investigate the potential mechanism of Danhong injection (DHI) and the critical transcription factor SATB1 in preventing neuronal ferroptosis after ischemic stroke in vivo and in vitro. The results showed that DHI treatment significantly reduced the infarct area and associated damage in the brains of the pMCAO mice, and enhanced the viability of OGD-injured neurons. And several characteristic indica...
Source: Molecular Neurobiology - December 17, 2022 Category: Neurology Source Type: research
Extended Ischemic Recovery After Implantation of Human Mesenchymal Stem Cell Aggregates Indicated by Sodium MRI at 21.1 T
AbstractExtended therapeutic application remains a significant issue in the use of stem cell therapies to treat ischemic stroke. Along these lines, neurological recovery in a rodent model of ischemic stroke was evaluated following implantation of human mesenchymal stem cell aggregates (hMSC-agg), labeled with micron-sized particles of iron oxide, directly into the lateral ventricle contralateral to the ischemic lesion hemisphere. Longitudinally, disease progression and response to hMSC-agg therapy were assessed by1H and23Na magnetic resonance imaging (MRI) at 21.1 T to investigate cellular localization, migration, and re...
Source: Translational Stroke Research - February 7, 2022 Category: Neurology Source Type: research
Translational Molecular Imaging Tool of Vulnerable Carotid Plaque: Evaluate Effects of Statin Therapy on Plaque Inflammation and American Heart Association –Defined Risk Levels in Cuff-Implanted Apolipoprotein E–Deficient Mice
AbstractIdentification of high-risk carotid plaques in asymptomatic patients remains a challenging but crucial step in stroke prevention. The challenge is to accurately monitor the development of high-risk carotid plaques and promptly identify patients, who are unresponsive to best medical therapy, and hence targeted for carotid surgical interventions to prevent stroke. Inflammation is a key operator in destabilisation of plaques prior to clinical sequelae. Currently, there is a lack of imaging tool in routine clinical practice, which allows assessment of inflammatory activity within the atherosclerotic plaque. Herein, we ...
Source: Translational Stroke Research - December 9, 2022 Category: Neurology Source Type: research
