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Nutrition: Calcium

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Total 95 results found since Jan 2013.

Micro RNA 181c-5p: a promising target for post-stroke recovery in socially isolated mice
Publication date: Available online 10 November 2019Source: Neuroscience LettersAuthor(s): Maria Antony, Victoria Scranton, Pranay Srivastava, Rajkumar VermaAbstractDysregulation of microRNAs (miRNAs) has been tied to several neurological disorders, including ischemic stroke. It has also been established that social environments can modulate miRNA profiles. We have previously shown that post-stroke social isolation (SI) is linked to poor stroke outcomes and that miR-181c-5p emerged as one of few lead miRNAs that was downregulated in both stroke and SI. Therefore, in this study we examined the potential role of miR-181c-5p m...
Source: Neuroscience Letters - November 11, 2019 Category: Neuroscience Source Type: research

Epigenetics and stroke: role of DNA methylation and effect of aging on blood –brain barrier recovery
This study aimed to evaluate the epigenetic and transcriptiona l profile of cerebral microvessels after thromboembolic (TE) stroke to define potential causes of limited BBB recovery. RNA-sequencing and reduced representation bisulfite sequencing (RRBS) analyses were performed using microvessels isolated from young (6 months) and old (18 months) mice seven day s poststroke compared to age-matched sham controls. DNA methylation profiling of poststroke brain microvessels revealed 11,287 differentially methylated regions (DMR) in old and 9818 DMR in young mice, corresponding to annotated genes. These DMR were enriched in gen...
Source: Fluids and Barriers of the CNS - February 28, 2023 Category: Neuroscience Source Type: research

Inhibition of Calcium/Calmodulin ‐Dependent Protein Kinase Kinase (CaMKK) Exacerbates Impairment of Endothelial Cell and Blood‐Brain Barrier after Stroke
This article is protected by copyright. All rights reserved.
Source: European Journal of Neuroscience - November 13, 2018 Category: Neuroscience Authors: Ping Sun, Fan Bu, Jia ‐Wei Min, Yashasvee Munshi, Matthew D. Howe, Lin Liu, Edward C.  Koellhoffer, Li Qi, Louise D.  McCullough, Jun Li Tags: Research Report Source Type: research

The Pyk2/MCU Pathway in the Rat Middle Cerebral Artery Occlusion Model of Ischemic Stroke
In this study, we explored the role of the Pyk2/MCU pathway in the ischemic brain following a stroke injury. We found that the Pyk2/MCU pathway is activated in a rat cerebral ischemia model, and is responsible for mitochondrial dysfunction and neuronal apoptosis. Inhibiting the Pyk2/MCU pathway with a Pyk2 inhibitor (PF-431396) prevented mitochondrial Ca2+ overload, mitochondrial injury, proapoptotic protein release, and cell death. Interestingly, human urinary kallidinogenase (HUK) alleviated neuronal ischemic injury by inhibiting the Pyk2/MCU pathway, suggesting that the Pyk2/MCU pathway may be a protective target for is...
Source: Neuroscience Research - September 12, 2017 Category: Neuroscience Source Type: research

The Pyk2/MCU pathway in the rat middle cerebral artery occlusion model of ischemic stroke
In this study, we explored the role of the Pyk2/MCU pathway in the ischemic brain following a stroke injury. We found that the Pyk2/MCU pathway is activated in a rat cerebral ischemia model, and is responsible for mitochondrial dysfunction and neuronal apoptosis. Inhibiting the Pyk2/MCU pathway with a Pyk2 inhibitor (PF-431396) prevented mitochondrial Ca2+ overload, mitochondrial injury, proapoptotic protein release, and cell death. Interestingly, human urinary kallidinogenase (HUK) alleviated neuronal ischemic injury by inhibiting the Pyk2/MCU pathway, suggesting that the Pyk2/MCU pathway may be a protective target for is...
Source: Neuroscience Research - July 5, 2018 Category: Neuroscience Source Type: research

Retinoic Acid Prevents the Neuronal Damage Through the Regulation of Parvalbumin in an Ischemic Stroke Model
In conclusion, retinoic acid contributes to the preservation of neurons from ischemic stroke by controlling parvalbumin expression and apoptosis-related proteins.PMID:36245066 | DOI:10.1007/s11064-022-03769-9
Source: Neurochemical Research - October 16, 2022 Category: Neuroscience Authors: Ju-Bin Kang Dong-Ju Park Phil-Ok Koh Source Type: research

Magnesium as a Neuroprotective Agent: A Review of Its Use in the Fetus, Term Infant with Neonatal Encephalopathy, and the Adult Stroke Patient
This article explores the current status of magnesium being used as an adjunct to hypothermia in term neonatal encephalopathy (NE) against a background of its use in other populations. There is some evidence for magnesium sulfate as a neuroprotective agent, however animal studies of NE at term equivalent age have been confounded by concomitant hypothermia induced by magnesium itself. Nevertheless, the combination of magnesium and cooling has been shown to be more effective than either treatment alone in adult rodents. In the preterm baby, magnesium sulfate given antenatally in threatened preterm labor has demonstrated a si...
Source: Developmental Neuroscience - February 7, 2018 Category: Neuroscience Source Type: research

Roles Played by the Na+/Ca2+ Exchanger and Hypothermia in the Prevention of Ischemia-Induced Carrier-Mediated Efflux of Catecholamines into the Extracellular Space: Implications for Stroke Therapy.
Abstract The release of [3H]dopamine ([3H]DA) and [3H]noradrenaline ([3H]NA) in acutely perfused rat striatal and cortical slice preparations was measured at 37 °C and 17 °C under ischemic conditions. The ischemia was simulated by the removal of oxygen and glucose from the Krebs solution. At 37 °C, resting release rates in response to ischemia were increased; in contrast, at 17 °C, resting release rates were significantly reduced, or resting release was completely prevented. The removal of extracellular Ca2+ further increased the release rates of [3H]DA and [3H]NA induced by ischemic conditions. This findi...
Source: Neurochemical Research - July 24, 2019 Category: Neuroscience Authors: Lakatos M, Baranyi M, Erőss L, Nardai S, Török TL, Sperlágh B, Vizi ES Tags: Neurochem Res Source Type: research