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Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation
In this study, we investigated factors that influence the effect of intravenous thrombolysis in these patients. Our results showed that thrombolysis was independently associated with a favorable outcome (P < 0.001) and did not influence the mortality of AF-related ischemic stroke, although it increased the risk of hemorrhage within 24 h after treatment. Risk factors for a poor outcome at admission were: heart failure (P = 0.045); high systolic pressure (P = 0.039); high blood glucose (P = 0.030); and a high National Institutes of Health Stroke Scale (NIHSS) score (P < 0.001). Moreover, high systolic pressur...
Source: Neuroscience Bulletin - March 7, 2016 Category: Neuroscience Source Type: research

Worse Neurological State During Acute Ischemic Stroke is Associated with a Decrease in Serum Albumin Levels
This study aimed to determine whether serum albumin levels within the first days after IS correlate with radiological and biochemical markers of brain tissue damage. Fifty-six IS patients were enrolled into the study. Neurological examinations were based on the National Institute of Health Stroke Scale. Serum albumin levels and S100BB were evaluated using commercially available ELISA kits. The albumin decrease index (ADI) was calculated as the difference between serum albumin levels measured on days 1 and 10 of IS. All parameters were estimated on the 1st, 3rd, 5th, and 10th days of IS, and the volume of ischemic focus was...
Source: Journal of Molecular Neuroscience - January 12, 2016 Category: Neuroscience Source Type: research

Direct admission to stroke centers reduces treatment delay and improves clinical outcome after intravenous thrombolysis
Publication date: Available online 9 January 2016 Source:Journal of Clinical Neuroscience Author(s): Dae-Hyun Kim, Hee-Joon Bae, Moon-Ku Han, Beom Joon Kim, Sang-Soon Park, Tai Hwan Park, Kyung Bok Lee, Kyusik Kang, Jong-Moo Park, Youngchai Ko, Soo Joo Lee, Jay Chol Choi, Joon-Tae Kim, Ki-Hyun Cho, Keun-Sik Hong, Yong-Jin Cho, Dong-Eog Kim, Jun Lee, Juneyoung Lee, Mi Sun Oh, Kyung-Ho Yu, Byung-Chul Lee, Hyun-Wook Nah, Jae-Kwan Cha We aimed to examine whether direct access to hospitals offering intravenous thrombolysis is associated with functional outcomes in patients with acute ischemic stroke tr...
Source: Journal of Clinical Neuroscience - January 11, 2016 Category: Neuroscience Source Type: research

Impact of early enteral nutrition on short term prognosis after acute stroke
Publication date: Available online 14 July 2015 Source:Journal of Clinical Neuroscience Author(s): Tianheng Zheng , Xinpu Zhu , Huazheng Liang , Haixia Huang , Jiandao Yang , Shaoshi Wang We hypothesized that early enteral nutritional support would improve the short term prognosis of acute stroke patients with dysphagia, demonstrated by lower malnutrition rates, lower complication rates, and lower National Institutes of Health Stroke Scale (NIHSS) scores at 90days post stroke. Nutrition support is an essential element in the care of stroke patients and many studies have investigated the effect of specific nutritional ele...
Source: Journal of Clinical Neuroscience - July 14, 2015 Category: Neuroscience Source Type: research

Increased High-Sensitivity Troponin-T Levels Are Associated with Mortality After Ischemic Stroke
This study indicates that elevated troponin is an independent marker for severe deficits on presentation and for mortality in stroke patients.
Source: Journal of Molecular Neuroscience - June 11, 2015 Category: Neuroscience Source Type: research

Magnetisation transfer parameters and stroke outcome
Publication date: Available online 16 April 2015 Source:Journal of Clinical Neuroscience Author(s): I. Sibon , T. Tourdias , S. Felix , J. Asselineau , L. Bracoud , A. Vivot , F. Rouanet , P. Renou , J.M. Orgogozo , V. Dousset Our aim was to evaluate the association between magnetisation transfer imaging (MTI) parameters measured 30 to 45days after a cerebrovascular insult and post-stroke functional outcome at the same time. MTI offers the opportunity to depict subtle microstructural changes in infarcted areas. The clinical significance of the heterogeneity of brain damage within ischaemic stroke lesions is unknown. We p...
Source: Journal of Clinical Neuroscience - April 28, 2015 Category: Neuroscience Source Type: research

Development of Regional Stroke Programs
Abstract The organization of stroke care has undergone a dramatic evolution in the USA over the last two decades. Beginning with the recommendation for Primary Stroke Centers (PSCs) in 1994, there has been a concerted effort by physicians, the American Heart Association/American Stroke Association (AHA/ASA), National Institutes of Health (NIH), and state legislatures to advance an evidence-based system of care with several tiers of stroke centers. At the apex of this structure are Regional Stroke Centers (RSCs), which do not have official recognition like PSCs and Comprehensive Stroke Centers (CSCs), but their ex...
Source: Current Neurology and Neuroscience Reports - March 13, 2015 Category: Neuroscience Source Type: research

Predictors of malignant brain edema in middle cerebral artery infarction observed on CT angiography
Publication date: March 2015 Source:Journal of Clinical Neuroscience, Volume 22, Issue 3 Author(s): Hoon Kim , Seon Tak Jin , Young Woo Kim , Seong Rim Kim , Ik Seong Park , Kwang Wook Jo Patients with middle cerebral artery (MCA) infarction accompanied by MCA occlusion with or without internal carotid artery (ICA) occlusion have a poor prognosis, as a result of brain cell damage caused by both the infarction and by space-occupying and life-threatening edema formation. Multiple treatments can reduce the likelihood of edema formation, but tend to show limited efficacy. Decompressive hemicraniectomy with duroplasty has bee...
Source: Journal of Clinical Neuroscience - February 16, 2015 Category: Neuroscience Source Type: research

Downregulation of serum brain specific microRNA is associated with inflammation and infarct volume in acute ischemic stroke
Publication date: February 2015 Source:Journal of Clinical Neuroscience, Volume 22, Issue 2 Author(s): Yanping Liu , Junjian Zhang , Rongfei Han , Hanxing Liu , Dong Sun , Xuan Liu Cerebral ischemic injury activates a robust inflammatory response, exacerbating neurological deficit. Several brain specific microRNA (miRNA) molecules have been reported to mediate functioning of the immune system, referred to as NeurimmiR. We aimed to explore possible associations between serum miRNA levels and stroke severity and their involvement in the regulation of inflammatory responses after stroke. Blood samples were obtained from 31 ...
Source: Journal of Clinical Neuroscience - January 14, 2015 Category: Neuroscience Source Type: research

Predictors of Poor Hospital Discharge Outcome in Acute Stroke Due To Atrial Fibrillation
ABSTRACT: Atrial fibrillation (AF) is a frequent cause of acute ischemic stroke that results in severe neurological disability and death despite treatment with intravenous thrombolysis (intravenous recombinant tissue plasminogen activator [rtPA]). We performed a retrospective review of a single-center registry of patients treated with intravenous rtPA for stroke. The purposes of this study were to compare intravenous rtPA treated patients with stroke with and without AF to examine independent predictors of poor hospital discharge outcome (in-hospital death or hospital discharge to a skilled nursing facility, long-term acut...
Source: Journal of Neuroscience Nursing - January 13, 2015 Category: Neuroscience Tags: Article Source Type: research

Saving the ischemic penumbra: Endovascular thrombolysis versus medical treatment
We present the first study to our knowledge comparing the ischemic penumbra saved with endovascular versus medical therapy. A retrospective review of 21 patients undergoing endovascular intervention for stroke from 2010 to 2011 was contrasted with 21 consecutive patients treated with antiplatelet agents alone. Immediate computed tomography perfusion (CTP) scan of the head and neck was obtained in all patients. Patients with lacunar and posterior circulation infarcts, and those who were medically unstable for MRI post-operatively were excluded. CTP and MRI underwent volumetric calculation. CTP penumbra was correlated with d...
Source: Journal of Clinical Neuroscience - November 29, 2014 Category: Neuroscience Source Type: research

Prolyl Carboxypeptidase Activity Decline Correlates with Severity and Short-Term Outcome in Acute Ischemic Stroke.
Abstract Prolyl carboxypeptidase (PRCP) is an enzyme associated with cerebrovascular risk factors such as hypertension, diabetes mellitus, obesity and hyperlipidemia. We aim to evaluate the relation between serum PRCP activity and severity, evolution and outcome of acute ischemic stroke. We used a specific RP-HPLC activity assay to measure PRCP activity in serum of 50 stroke patients at admission, and at 24 h, 72 h and 7 days after stroke onset to assess correlations with stroke severity based on the National Institutes of Health Stroke scale score (NIHSS), infarct volume on brain MRI scan, stroke outcome based...
Source: Neurochemical Research - November 5, 2014 Category: Neuroscience Authors: Kehoe K, Brouns R, Verkerk R, Engelborghs S, De Deyn PP, Hendriks D, De Meester I Tags: Neurochem Res Source Type: research

Neuron Specific Enolase and C-reactive Protein Levels in Stroke and Its Subtypes: Correlation with Degree of Disability.
Abstract Stroke is an emergency which threatens life and third leading cause of death and long term disability in developed countries. The use of biomarkers in diagnosing stroke and assessing prognosis is an emerging and rapidly evolving field. The study aimed to investigate the predictive value of biochemical marker of brain damage neuron-specific enolase (NSE) and systemic inflammatory marker C-reactive protein (CRP) with respect to degree of disability at the time of admission and short term in stroke patients. We investigated 120 patients with cerebrovascular stroke who were admitted within 72 h of onset of s...
Source: Neurochemical Research - May 17, 2014 Category: Neuroscience Authors: Pandey A, Shrivastava AK, Saxena K Tags: Neurochem Res Source Type: research

Prognostic Value of Serum 25-Hydroxyvitamin D in Patients with Stroke.
Abstract We aimed to evaluate the association between 25-hydroxyvitamin D [25(OH) D] levels and both clinical severity at admission and outcome at discharge in patients with acute ischemic stroke (AIS). From June 2012 to October 2013, consecutive first-ever AIS patients admitted to the Department of Emergency of The Fourth Affiliated Hospital of Harbin Medical University, China were identified. Clinical information was collected. Serum 25(OH) D levels were measured at baseline. Stroke severity was assessed at admission using the National Institutes of Health Stroke Scale (NIHSS) score. Functional outcome was evalu...
Source: Neurochemical Research - May 1, 2014 Category: Neuroscience Authors: Wang Y, Ji H, Tong Y, Zhang ZB Tags: Neurochem Res Source Type: research

The Relationship Between Serum Mannose-Binding Lectin Levels and Acute Ischemic Stroke Risk.
Abstract Complement activation and inflammation have been suggested in the pathogenesis of stroke, mannose-binding lectin (MBL) were found to have roles during the process. The aim of this study was to investigate the relationship between acute ischemic stroke (AIS) and serum MBL levels in Chinese population. From January 1 to June 30 2013, all patients with first-ever AIS were recruited to participate in the study. Serum MBL levels and routine test were examined. The National Institutes of Health Stroke Scale (NIHSS) score was assessed on admission blinded to MBL levels. During the inclusion period, 148 patients ...
Source: Neurochemical Research - December 6, 2013 Category: Neuroscience Authors: Wang ZY, Sun ZR, Zhang LM Tags: Neurochem Res Source Type: research

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