Magnetisation transfer parameters and stroke outcome

Publication date: Available online 16 April 2015 Source:Journal of Clinical Neuroscience Author(s): I. Sibon , T. Tourdias , S. Felix , J. Asselineau , L. Bracoud , A. Vivot , F. Rouanet , P. Renou , J.M. Orgogozo , V. Dousset Our aim was to evaluate the association between magnetisation transfer imaging (MTI) parameters measured 30 to 45days after a cerebrovascular insult and post-stroke functional outcome at the same time. MTI offers the opportunity to depict subtle microstructural changes in infarcted areas. The clinical significance of the heterogeneity of brain damage within ischaemic stroke lesions is unknown. We prospectively included 58 patients with acute middle cerebral artery stroke. Diffusion-weighted imaging was performed within 12hours after onset and the final infarct was documented by MRI with fluid-attenuated inversion recovery (FLAIR) and MTI at 30 to 45days follow-up. We evaluated the association between MTI histogram parameters and the clinical outcome assessed by dichotomised (threshold >2) modified rankin scale (mRS) using multivariable logistic regression models adjusted on baseline characteristics. In multivariable analyses, stroke outcome was mostly driven by initial National Institutes of Health Stroke Scale (odds ratio [OR]=1.23; 95% confidence interval [CI]=1.07–1.41; p <0.01) while after adjustment of initial stroke severity magnetisation transfer ratio peak position was the only MRI parameter associated with function...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research