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Specialty: Neurology
Management: National Institutes of Health (NIH)
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Total 425 results found since Jan 2013.
High Plasma Levels of d -Dimer Are Independently Associated with a Heightened Risk of Deep Vein Thrombosis in Patients with Intracerebral Hemorrhage
AbstractDeep venous thrombosis (DVT) is a complication of stroke. Our aim was to determine whetherd-dimer plasma levels at admission could be a risk factor for DVT in Chinese patients with acute intracerebral hemorrhage (ICH). From December 2012 to November 2014, all patients with first-ever acute ICH were included. At baseline, the demographical and clinical data were taken. These patients were assessed for DVT using color Doppler ultrasonography (CDUS) on 15 days after ICH and whenever clinically requested. Multivariate analyses were performed using logistic regression models. Receiver operating characteristic (ROC) cu...
Source: Molecular Neurobiology - September 6, 2016 Category: Neurology Source Type: research
Visual Determination of Conjugate Eye Deviation on Computed Tomography Scan Predicts Diagnosis of Stroke Code Patients
Head computed tomography (CT) is critical for stroke code evaluations and often happens prior to completion of the neurological exam. Eye deviation on neuroimaging (DeyeCOM sign) has utility for predicting stroke diagnosis and correlates with National Institutes of Health Stroke Scale (NIHSS) gaze score. We further assessed the utility of the DeyeCOM sign, without complex caliper-based eye deviation calculations, but simply with a visual determination method.
Source: Journal of Stroke and Cerebrovascular Diseases - August 26, 2016 Category: Neurology Authors: Ilana Spokoyny, James Y. Chen, Rema Raman, Karin Ernstrom, Kunal Agrawal, Royya F. Modir, Dawn M. Meyer, Brett C. Meyer Source Type: research
Cerebellar Infarction and Factors Associated with Delayed Presentation and Misdiagnosis
Background and Purpose: The diagnosis of cerebellar infarction (CBI) is often challenging due to non-specific or subtle presenting symptoms and signs. We aimed to determine whether a common syndromic cluster of symptoms, signs or vascular risk factors were associated with delayed presentation or misdiagnosis to an Emergency Department (ED). The degree of misdiagnosis between ED and neurology physicians and the influence of delayed presentation or misdiagnosis on outcome were also investigated.Methods: A prospective study of CBI patients at a large tertiary-referral hospital with a comprehensive stroke service. Data are rep...
Source: Cerebrovascular Diseases - August 26, 2016 Category: Neurology Source Type: research
Associations between Thyroid Stimulating Hormone Levels and Both Severity and Early Outcome of Patients with Ischemic Stroke
We aimed to investigate associations between serum thyroid stimulating hormone (TSH) levels and both severity and outcome after ischemic stroke (IS). A total of 731 patients consecutive IS patients were enrolled (mean age 69.4 ± 15.4, 61.6% men), and serum TSH levels were measured at admission and analyzed according to the tertiles of their distribution (1.6 mUI/l). Associations between TSH and both severity at admission (National Institutes of Health Stroke Scale (NIHSS) scores
Source: European Neurology - August 26, 2016 Category: Neurology Source Type: research
Effective ADAPT Thrombectomy in a Patient with Acute Stroke due to Cardiac Papillary Elastofibroma: Histological Thrombus Confirmation
A 75-year-old man with hypertension and atrial fibrillation was admitted to our emergency room with right-sided hemiplegia and complete aphasia (National Institutes of Health Stroke Scale [NIHSS] score = 18). A noncontrast computed tomography scan showed a slight hypodensity in the left insular region and a bright hyperdense sign in the M1 tract of the left middle cerebral artery (MCA). Angio-CT confirmed an occlusion of the M1 tract of the MCA. Magnetic resonance diffusion-weighted imaging/p erfusion-weighted imaging was obtained and revealed a mismatch in the left parietal cortical region.
Source: Journal of Stroke and Cerebrovascular Diseases - August 14, 2016 Category: Neurology Authors: Francesco Biraschi, Francesco Diana, Francesco Alesini, Giulio Guidetti, Simone Peschillo Tags: Case Studies Source Type: research
NIH-funded study supports surgery as treatment for myasthenia gravis
In a global study of myasthenia gravis, an autoimmune disease that causes muscle weakness and fatigue, researchers found that surgical removal of an organ called the thymus reduced patients ’ weakness, and their need for immunosuppressive drugs. The study, published in the New England Journal of Medicine, was partially funded by the National Institutes of Health.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - August 10, 2016 Category: Neurology Source Type: news
Novel genetic mutation may lead to the progressive loss of motor function
Researchers from the National Institutes of Health and their colleagues identified the genetic cause and a possible therapeutic target for a rare form of pediatric progressive neuropathy. Neuropathy, damage or disease affecting the peripheral nervous system, can range from rare conditions linked to a patient ’s exome to more common causes like diabetes and viral infections.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - August 3, 2016 Category: Neurology Source Type: news
Too good to treat? ischemic stroke patients with small computed tomography perfusion lesions may not benefit from thrombolysis
In this study, we tested the hypothesis that a small acute perfusion lesion predicts good clinical outcome regardless of thrombolysis administration.
MethodsWe used a prospectively collected cohort of acute ischemic stroke patients being assessed for treatment with IV‐alteplase, who had CTP before a treatment decision. Volumetric CTP was retrospectively analyded to identify patients with a small perfusion lesion (<15ml in volume). The primary analysis was excellent 3‐month outcome in patients with a small perfusion lesion who were treated with alteplase compared to those who were not treated.
ResultsOf 1526 patients...
Source: Annals of Neurology - July 25, 2016 Category: Neurology Authors: Andrew Bivard, Min Lou, Christopher R. Levi, Venkatesh Krishnamurthy, Xin Cheng, Richard I. Aviv, Patrick McElduff, Longting Lin, Tim Kleinig, Billy O'Brien, Kenneth Butcher, Zhang Jingfen, Jim Jannes, Qiang Dong, Mark W. Parsons Tags: Research Article Source Type: research
Accuracy of National Institutes of Health Stroke Scale Score in Predicting the Site of Arterial Occlusion in Acute Stroke: A Transcranial Doppler Study
In this study we aimed to determine the following: (1) if there is a correlation between the site of occlusion and the NIHSSS at presentation (bNIHSSS); and (2) if there is a bNIHSSS cutoff which can distinguish proximal occlusions (PO) from distal occlusions (DO).
Source: Journal of Stroke and Cerebrovascular Diseases - July 24, 2016 Category: Neurology Authors: Deepak Gupta, Arvind Sharma, Ken Uchino, Andrei V. Alexandrov, Khurshid Khan, Ashfaq Shuaib, Maher Saqqur Source Type: research
Chapter 66 Endovascular treatment of acute ischemic stroke
Publication date: 2016 Source:Handbook of Clinical Neurology, Volume 136 Author(s): Thabele Leslie-Mazwi, James Rabinov, Joshua A. Hirsch Endovascular thrombectomy is an effective treatment for major acute ischemic stroke syndromes caused by major anterior circulation artery occlusions (commonly referred to as large vessel occlusion) and is superior to intravenous thrombolysis and medical management. Treatment should occur as quickly as is reasonably possible. All patients with moderate to severe symptoms (National Institutes of Health stroke scale >8) and a treatable occlusion should be considered. The use of ...
Source: Handbook of Clinical Neurology - July 16, 2016 Category: Neurology Source Type: research
Prospective, open ‐label safety study of intravenous recombinant tissue plasminogen activator in wake‐up stroke
ObjectiveIt is estimated that one of four ischemic strokes are noticed upon awakening and are not candidates for intravenous recombinant tissue plasminogen activator (rtPA) because their symptoms are >3 hours from last seen normal (LSN). We tested the safety of rtPA in a multicenter, single‐arm, prospective, open‐label study (NCT01183533) in patients with wake‐up stroke (WUS).
MethodsWe aimed to enroll 40 WUS patients with disabling deficits. Patients were 18 to 80 years of age, National Institutes of Health Stroke Scale (NIHSS) ≤25, and selected only on the appearance of noncontrast computed tomography (ie, ove...
Source: Annals of Neurology - July 11, 2016 Category: Neurology Authors: Andrew D. Barreto, Christopher V. Fanale, Andrei V. Alexandrov, Kevin C. Gaffney, Farhaan S. Vahidy, Claude B. Nguyen, Amrou Sarraj, Mohammad Rahbar, James C. Grotta, Sean I. Savitz, Tags: Research Article Source Type: research
Prospective, open‐label safety study of intravenous recombinant tissue plasminogen activator in wake‐up stroke
ObjectiveIt is estimated that one of four ischemic strokes are noticed upon awakening and are not candidates for intravenous recombinant tissue plasminogen activator (rtPA) because their symptoms are >3 hours from last seen normal (LSN). We tested the safety of rtPA in a multicenter, single‐arm, prospective, open‐label study (NCT01183533) in patients with wake‐up stroke (WUS).
MethodsWe aimed to enroll 40 WUS patients with disabling deficits. Patients were 18 to 80 years of age, National Institutes of Health Stroke Scale (NIHSS) ≤25, and selected only on the appearance of noncontrast computed tomography (ie, ove...
Source: Annals of Neurology - July 11, 2016 Category: Neurology Authors: Andrew D. Barreto, Christopher V. Fanale, Andrei V. Alexandrov, Kevin C. Gaffney, Farhaan S. Vahidy, Claude B. Nguyen, Amrou Sarraj, Mohammad Rahbar, James C. Grotta, Sean I. Savitz, Tags: Research Article Source Type: research
New imaging method may predict risk of post-treatment brain bleeding after stroke
In a study of stroke patients, investigators confirmed through MRI brain scans that there was an association between the extent of disruption to the brain’s protective blood-brain barrier and the severity of bleeding following invasive stroke therapy. The results of the National Institutes of Health-funded study were published in Neurology.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - June 17, 2016 Category: Neurology Source Type: news
Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis
Publication date: Available online 8 June 2016 Source:The Lancet Neurology Author(s): William N Whiteley, Jonathan Emberson, Kennedy R Lees, Lisa Blackwell, Gregory Albers, Erich Bluhmki, Thomas Brott, Geoff Cohen, Stephen Davis, Geoffrey Donnan, James Grotta, George Howard, Markku Kaste, Masatoshi Koga, Rüdiger von Kummer, Maarten G Lansberg, Richard I Lindley, Patrick Lyden, Jean Marc Olivot, Mark Parsons, Danilo Toni, Kazunori Toyoda, Nils Wahlgren, Joanna Wardlaw, Gregory J del Zoppo, Peter Sandercock, Werner Hacke, Colin Baigent Background Randomised trials have shown that alteplase impr...
Source: The Lancet Neurology - June 8, 2016 Category: Neurology Source Type: research
