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Total 7133 results found since Jan 2013.
Psychopharmacotherapy during pregnancy and breastfeeding-Part I: focus on pregnancy : Support options by using therapeutic drug monitoring
Nervenarzt. 2023 Jul 17. doi: 10.1007/s00115-023-01528-x. Online ahead of print.ABSTRACTThe medicinal treatment of mental disorders during pregnancy and lactation requires special knowledge about possible effects of the psychopharmacotherapy on the intrauterine exposure of the embryo/fetus. Therefore, the first part of this 2‑part article focuses on the use of psychotropic drugs during pregnancy. In the second part, the use of psychotropic drugs during breastfeeding is addressed. Possible substance-specific risks as a consequence of the administration have to be assessed compared to the natural risk of pregnancy complica...
Source: Der Nervenarzt - July 17, 2023 Category: Neurology Authors: Michael Paulzen Georgios Schoretsanitis Source Type: research
Galactagogues and Lactation: Considerations for Counseling Breastfeeding Mothers
Development of a milk supply is a complex process that is not always understood by women who are breastfeeding. Galactagogues are substances commonly used by breastfeeding women who perceive that they have an insufficient milk supply. They can be herbal substances or pharmaceuticals. Herbal galactagogues are advertised and sold to women as capsules, cookies, milk shakes, and teas, as well as other forms of herbal supplements. Herbal galactagogues are classified as dietary supplements and not reviewed or regulated by the U.S. Food and Drug Administration. There are limited data on their safety and efficacy. Women experienci...
Source: MCN: The American Journal of Maternal Child Nursing - April 30, 2022 Category: Nursing Tags: Feature: NCPD Connection Source Type: research
Use of internet search logs to evaluate potential drug adverse events.
Abstract
Internet search logs provide an abundant source of data that can be explored for purposes such as identifying drug exposure-adverse event relationships. The methodology to rigorously conduct such evaluations is not well characterized, and the utility of such analyses is not well defined. In this issue, White and colleagues propose an approach using Internet search logs for this purpose and compare it to parallel analyses conducted using the US Food and Drug Administration's spontaneous reporting database.
PMID: 25056395 [PubMed - in process]
Source: Clinical Pharmacology and Therapeutics - July 28, 2014 Category: Drugs & Pharmacology Authors: Sarntivijai S, Abernethy DR Tags: Clin Pharmacol Ther Source Type: research
Search for Inhibitors of the Ubiquitin-Proteasome System from Natural Sources for Cancer Therapy.
Abstract
Since the approval of the proteasome inhibitor, Velcade(®), by the Food and Drug Administration (FDA) for the treatment of relapsed multiple myeloma, inhibitors of the ubiquitin-proteasome system have been attracting increasing attention as promising drug leads for cancer therapy. While the development of drugs for diseases related to this proteolytic system has mainly been achieved by searching libraries of synthetic small molecules or chemical modifications to drug leads, limited searches have been conducted on natural sources. We have been searching natural sources for inhibitors that target this prot...
Source: Chemical and Pharmaceutical Bulletin - February 3, 2016 Category: Drugs & Pharmacology Authors: Tsukamoto S Tags: Chem Pharm Bull (Tokyo) Source Type: research
FDA Was Right To Block 23andMe
A few techno-libertarians are up in arms over the FDA’s letter warning the genetics company 23andMe to stop selling its personalized genome services kit. But a quick search of the Food and Drug Administration’s admittedly user-unfriendly website shows federal regulators have been targeting various low-cost genetic testing ventures to provide the necessary analysis that goes along with a proper genetic screening for at least the past three years.At present, getting raw data about your personal genome is worse than useless, as Nancy Shute pointed out in a Scientific American article that I edited back in 2012. &#...
Source: Scientific American - Official RSS Feed - November 25, 2013 Category: Science Tags: Health Source Type: research
Clarification of P-glycoprotein inhibition-related drug-drug interaction risks based on a literature search of the clinical information.
Abstract
Abstract 1. Recently, the Food and Drug Administration (FDA) and European Medicines Agency have shown decision trees to determine whether a drug candidate is an inhibitor of P-glycoprotein (P-gp). However, there has been no clear information on whether P-gp inhibition can be significant in clinical drug-drug interactions (DDIs). The purpose of this study was to confirm the effect of P-gp inhibition through comprehensive analysis of the clinical DDI studies. 2. Clinical information on P-gp inhibition was collected using the University of Washington Metabolism and Transport Drug Interaction Database...
Source: Xenobiotica - June 17, 2014 Category: Research Authors: Umeyama Y, Fujioka Y, Okuda T Tags: Xenobiotica Source Type: research
Title: In Search of “Just Right”: The Challenge of Regulating Arsenic in Rice
Charles W. Schmidt, MS, an award-winning science writer from Portland, ME, has written for Discover Magazine, Science, and Nature Medicine.
Background image: © Koji Kitagawa/amanaimages/Corbis
About This Article open
Citation: Schmidt CW. 2015. In search of “just right”: the challenge of regulating arsenic in rice. Environ Health Perspect 123:A16–A19; http://dx.doi.org/10.1289/ehp.123-A16
News Topics: Agriculture and Farming, Arsenic, Diet and Nutrition, Drinking Water Quality, Food Safety and Regulation, Laws, Regulations, and Policy, Risk Assessment, Soil Pollution, Standards
Published: 1 January 2015
PDF Ver...
Source: EHP Research - December 31, 2014 Category: Environmental Health Authors: Web Admin Tags: Featured News Spheres of Influence Agriculture and Farming Arsenic Diet and Nutrition Drinking Water Quality Food Safety and Regulation Risk Assessment Soil Pollution Standards Source Type: research
The Search for an Alternative to 68GaGa-DOTA-TATE in Neuroendocrine Tumor Theranostics: Current State of 18F-labeled Somatostatin Analog Development
The trend to inform personalized molecular radiotherapy with molecular imaging diagnostics, a concept referred to as theranostics, has transformed the field of nuclear medicine in recent years. The development of theranostic pairs comprising somatostatin receptor (SSTR)-targeting nuclear imaging probes and therapeutic agents for the treatment of patients with neuroendocrine tumors (NETs) has been a driving force behind this development. With the Neuroendocrine Tumor Therapy (NETTER-1) phase 3 trial reporting encouraging results in the treatment of well-differentiated, metastatic midgut NETs, peptide radioligand therapy (RL...
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Christopher M. Waldmann, Andreea D. Stuparu, R. Michael van Dam, Roger Slavik Tags: Review Source Type: research
Web search popularity, publicity, and utilization of direct oral anticoagulants in the United States, 2008–2018: A STROBE-compliant study
We aimed to study the changing popularity of oral anticoagulants and the potential association between media coverage and real-world utilization practice, using time series analysis.
In this STROBE-compliant study, we used Google Trends data to study public interest for direct oral anticoagulants (DOACs) (dabigatran, rivaroxaban, apixaban, and edoxaban) and warfarin in the United States (10-year coverage, beginning July 1st, 2008 ending June 30th, 2018). We validated our findings on a sample of 50 consecutive datasets (accumulated between July 6th, 2018 and October 19th, 2018), using the same search criteria. We used the ...
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Plague vaccines: new developments in an ongoing search
Appl Microbiol Biotechnol. 2021 Jun 18. doi: 10.1007/s00253-021-11389-6. Online ahead of print.ABSTRACTAs the reality of pandemic threats challenges humanity, exemplified during the ongoing SARS-CoV-2 infections, the development of vaccines targeting these etiological agents of disease has become increasingly critical. Of paramount concern are novel and reemerging pathogens that could trigger such events, including the plague bacterium Yersinia pestis. Y. pestis is responsible for more human deaths than any other known pathogen and exists globally in endemic regions of the world, including the four corners region and North...
Source: Applied Microbiology and Biotechnology - June 18, 2021 Category: Microbiology Authors: Jason A Rosenzweig Emily K Hendrix Ashok K Chopra Source Type: research
Scientists use AI to identify likely drug targets in search for Alzheimer ' s cure
Scientists use AI to identify likely drug targets in search for Alzheimer's cure
A team led by a University of Arizona College of Medicine – Tucson scientist harnesses artificial intelligence to trace the path from a healthy brain cell to one afflicted by Alzheimer ' s disease.
Anna C. Christensen
Today
College of Medicine – TucsonRui-Chang_khp-web.jpg
Rui Chang, an associate professor of neurology, is leading a team at the College of Medicine – Tucson that uses artificial intelligence to trace the molecular path of the development of Alzheimer's disease.HealthCollege of Medicine - TucsonDeterminationE...
Source: The University of Arizona: Health - May 15, 2023 Category: Universities & Medical Training Authors: mittank Source Type: research
Summary of the joint National Institutes of Health and the Food and Drug Administration workshop titled “exploring the science surrounding the safe use of bioactive ingredients in infant formula: Considerations for an assessment framework”
The US government and many professional societies recommend that human milk be the sole source of nutrition for infants up to 6 months-of-age.1,2 However, only about 25% of infants in the US meet this goal signaling an urgent need for improved multi-level support for breastfeeding among societies, communities, and families.2 In addition, when breastfeeding is not possible, access to a safe and effective source of nutrition —provided by infant formula (IF) is critical. The search for bioactive ingredients found in human milk (HM) that could be added to formula has been intense among academic institutions, governmental res...
Source: The Journal of Pediatrics - December 1, 2022 Category: Pediatrics Authors: Sharon M. Donovan, Steven A. Abrams, Meghan B. Azad, Mandy B. Belfort, Lars Bode, Susan E. Carlson, David C. Dallas, Kasper Hettinga, Kirsi J ärvinen, Jae H. Kim, Carlito B. Lebrilla, Michelle K. McGuire, David A. Sela, Josef Neu Tags: Workshop/Symposium Summary Source Type: research
Safety of dermatologic medications in pregnancy and lactation: Part I. Pregnancy
Dermatologists are frequently faced with questions about the safety of commonly prescribed topical and systemic medications during pregnancy and lactation from women of childbearing age who are pregnant, considering pregnancy, or breastfeeding. Safety data, particularly regarding medications that are unique to dermatology, can be difficult to locate and are not consolidated in a single reference guide for clinicians. Parts I and II of this continuing medical education article provide a capsule summary of key points for the most commonly prescribed dermatologic medications to facilitate patient medication risk counseling in...
Source: Journal of the American Academy of Dermatology - February 19, 2014 Category: Dermatology Authors: Jenny E. Murase, Misha M. Heller, Daniel C. Butler Tags: Continuing Medical Education Source Type: research
