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Infectious Disease: Parasitic Diseases
Vaccination: Malaria Vaccine
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Total 411 results found since Jan 2013.
Sporozoite immunization: Innovative Translational Science to Support the Fight against malaria
Expert Rev Vaccines. 2023 Aug 11. doi: 10.1080/14760584.2023.2245890. Online ahead of print.ABSTRACTINTRODUCTION: Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly effective vaccine is urgently needed, especially for Plasmodium falciparum (Pf), the deadliest human malaria parasite.AREAS COVERED: Sporozoites (SPZ), the parasite stage transmitted by Anopheles mosquitoes to humans, are the only vaccine immunogen achieving > 90% efficacy against Pf infection. This review describes &g...
Source: Cancer Control - August 12, 2023 Category: Cancer & Oncology Authors: Thomas L Richie L W Preston Church Tooba Murshedkar Peter F Billingsley Eric R James Mei-Chun Chen Yonas Abebe None Natasha Kc Sumana Chakravarty David Dolberg Sara A Healy Halimatou Diawara Mahamadou S Sissoko Issaka Sagara David M Cook Judith E Epstein Source Type: research
Preliminary studies on the immunogenicity of a prime-and-trap malaria vaccine in nonhuman primates
Vaccine. 2023 Aug 8:S0264-410X(23)00913-1. doi: 10.1016/j.vaccine.2023.07.067. Online ahead of print.ABSTRACTDevelopment of next-generation vaccines against Plasmodium falciparum (Pf) is a priority. Many malaria vaccines target the pre-erythrocytic sporozoite (SPZ) and liver stages. These include subunit vaccines based on the Pf circumsporozoite protein (CSP) and attenuated PfSPZ vaccines. However, these strategies require 3-4 doses and have not achieved optimal efficacy against field-transmitted malaria. Prime-and-trap is a recently developed two-step heterologous vaccine strategy that combines priming with DNA encoding C...
Source: Vaccine - August 10, 2023 Category: Allergy & Immunology Authors: Melanie J Shears Felicia N Watson Brad C Stone Irene Cruz Talavera Chaitra Parthiban Jokichi Matsubara Natasha Kc B Kim Lee Sim Stephen L Hoffman Sean C Murphy Source Type: research
Designing an effective malaria vaccine targeting Plasmodium vivax Duffy-binding protein
Trends Parasitol. 2023 Jul 21:S1471-4922(23)00147-2. doi: 10.1016/j.pt.2023.06.011. Online ahead of print.ABSTRACTMalaria caused by the Plasmodium vivax parasite is a major global health burden. Immunity against blood-stage infection reduces parasitemia and disease severity. Duffy-binding protein (DBP) is the primary parasite protein responsible for the invasion of red blood cells and it is a leading subunit vaccine candidate. An effective vaccine, however, is still lacking despite decades of interest in DBP as a vaccine candidate. This review discusses the reasons for targeting DBP, the challenges associated with developi...
Source: Trends in Parasitology - July 22, 2023 Category: Parasitology Authors: Thayne H Dickey Niraj H Tolia Source Type: research
The immunity modulation of transforming growth factor- β in malaria and other pathological process
Int Immunopharmacol. 2023 Jul 17;122:110658. doi: 10.1016/j.intimp.2023.110658. Online ahead of print.ABSTRACTThe main causative agent of malaria in humans is Plasmodium falciparum, which is spread through biting Anopheles mosquitoes. Immunoregulation in the host involving the pleiotropic cytokine transforming growth factor-β (TGF-β) has a vital role in controlling the immune response to P. falciparum infection. Based on a search of the published literature, this study investigated the correlation between malaria and immune cells, specifically the role of TGF-β in the immune response. The studies analyzed showed that, w...
Source: International Immunopharmacology - July 19, 2023 Category: Allergy & Immunology Authors: Shuang Wu Qing Nie Shuang Tan Guoyan Liao Yinyi Lv Caohua Lv Guang Chen Shuangchun Liu Source Type: research
Genetic diversity and molecular evolution of Plasmodium vivax Duffy Binding Protein and merozoite surface protein-1 in northwestern Thailand
This study aimed to use amplicon sequencing to investigate the genotypic patterns and population structure of P. vivax isolates from a highly endemic province of Thailand in recent years. Amplicon deep sequencing was performed on 70 samples for the 42-kDa region of pvmsp1 and domain II of pvdbp. Unique haplotypes were identified and a network constructed to illustrate genetic relatedness in northwestern Thailand. Based on this dataset of 70 samples collected between 2015 and 2021, 16 and 40 unique haplotypes were identified in pvdbpII and pvmsp142kDa, respectively. Nucleotide diversity was higher in pvmsp142kDa than in pvd...
Source: Infection, Genetics and Evolution - June 17, 2023 Category: Genetics & Stem Cells Authors: Parsakorn Tapaopong Gustavo da Silva Sittinont Chainarin Chayanut Suansomjit Khajohnpong Manopwisedjaroen Liwang Cui Cristian Koepfli Jetsumon Sattabongkot Wang Nguitragool Source Type: research
Development of diphenylmethylpiperazine hybrids of chloroquinoline and triazolopyrimidine using Petasis reaction as new cysteine proteases inhibitors for malaria therapeutics
Eur J Med Chem. 2023 Jun 12;258:115564. doi: 10.1016/j.ejmech.2023.115564. Online ahead of print.ABSTRACTMalaria is a widespread infectious disease, causing nearly 247 million cases in 2021. The absence of a broadly effective vaccine and rapidly decreasing effectiveness of most of the currently used antimalarials are the major challenges to malaria eradication efforts. To design and develop novel antimalarials, we synthesized a series of 4,7-dichloroquinoline and methyltriazolopyrimidine analogues using a multi-component Petasis reaction. The synthesized molecules (11-31) were screened for in-vitro antimalarial activity ag...
Source: European Journal of Medicinal Chemistry - June 15, 2023 Category: Chemistry Authors: Hari Madhav Tarosh S Patel Zeba Rizvi G Srinivas Reddy Abdur Rahman Md Ataur Rahman Saiema Ahmedi Sadaf Fatima Kanika Saxena Nikhat Manzoor Souvik Bhattacharjee Bharat C Dixit Puran Singh Sijwali Nasimul Hoda Source Type: research
The most prominent modulated annexins during parasitic infections
Acta Trop. 2023 May 10:106942. doi: 10.1016/j.actatropica.2023.106942. Online ahead of print.ABSTRACTAnnexins (ANXs) exert different functions in cell biological and pathological processes and are thus known as double or multi-faceted proteins. These sophisticated proteins might express on both parasite structure and secretion and in parasite-infected host cells. In addition to the characterization of these pivotal proteins, describing their mechanism of action can be also fruitful in recognizing their roles in the pathogenesis of parasitic infections. Accordingly, this study presents the most prominent ANXs thus far ident...
Source: Acta Tropica - May 12, 2023 Category: Infectious Diseases Authors: Sajad Rashidi Reza Mansouri Mohammad Ali-Hassanzadeh Antonio Muro Paul Nguewa Ra úl Manzano-Román Source Type: research
Extending the range of Plasmodium falciparum transmission blocking antibodies
Vaccine. 2023 Apr 24:S0264-410X(23)00453-X. doi: 10.1016/j.vaccine.2023.04.042. Online ahead of print.ABSTRACTRecent work demonstrating that asymptomatic carriers of P. falciparum parasites make up a large part of the infectious reservoir highlights the need for an effective malaria vaccine. Given the historical challenges of vaccine development, multiple parasite stages have been targeted, including the sexual stages required for transmission. Using flow cytometry to efficiently screen for P. falciparum gamete/zygote surface reactivity, we identified 82 antibodies that bound live P. falciparum gametes/zygotes. Ten antibod...
Source: Vaccine - April 26, 2023 Category: Allergy & Immunology Authors: Lacy M Simons Patricia Ferrer Nita Gombakomba Knashka Underwood Raul Herrera David L Narum Gaspar Canepa Festus Acquah Linda Amoah Patrick E Duffy Carolina Barillas-Mury Carole Long Shwu-Maan Lee Emily Locke Kazutoyo Miura Kim C Williamson Source Type: research
