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Infectious Disease: Influenza

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Research and Reviews in the Fastlane 153
Welcome to the 153rd edition of Research and Reviews in the Fastlane. R&R in the Fastlane is a free resource that harnesses the power of social media to allow some of the best and brightest emergency medicine and critical care clinicians from all over the world tell us what they think is worth reading from the published literature. This edition contains 5 recommended reads. The R&R Editorial Team includes Jeremy Fried, Nudrat Rashid, Soren Rudolph, Justin Morgenstern and, of course, Chris Nickson. Find more R&R in the Fastlane reviews in the R&R Archive, read more about the R&R project or check o...
Source: Life in the Fast Lane - September 29, 2016 Category: Emergency Medicine Authors: Soren Rudolph Tags: Airway Clinical Research Education Emergency Medicine R&R in the FASTLANE Renal Resuscitation critical care Intensive Care research and reviews Trauma Source Type: blogs

Biomarkers for Acute Respiratory Distress syndrome and prospects for personalised medicine.
Abstract Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute respiratory distress syndrome (ARDS) being the most severe form of ALI and having a mortality rate in the region of 40%. There has been slow but incremental progress in identification of biomarkers that contribute to the pathophysiology of ARDS, have utility in diagnosis and monitoring, and that are potential therapeutic targets (Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA, Thompson T, Ware LB, Matthay MA, Lancet Respir Med 2014, 2:611--620). However, a major issue is that ARDS is such a ...
Source: Respiratory Care - January 26, 2019 Category: Respiratory Medicine Authors: Spadaro S, Park M, Turrini C, Tunstall T, Thwaites R, Mauri T, Ragazzi R, Ruggeri P, Hansel TT, Caramori G, Volta CA Tags: J Inflamm (Lond) Source Type: research

Coinfection With Flu, SARS - CoV - 2 Described in Children
SARS - CoV - 2 coinfection occurred in 6 percent of pediatric influenza - associated hospitalizations
Source: Pulmonary Medicine News - Doctors Lounge - October 12, 2017 Category: Respiratory Medicine Tags: Family Medicine, Internal Medicine, Critical Care, Emergency Medicine, Pediatrics, Pulmonology, Journal, Source Type: news

Influenza in children
Purpose of review: We review the current information and evidence available on the global burden of disease in the pediatric population, clinical presentation and complications, testing, treatment, and immunization. Recent findings: In addition to multiple other risk factors for influenza complications, children with neurologic and neuromuscular disorders are significantly higher risk for serious complications. In practice, there is no lower age limit for children with influenza who can be treated with oseltamivir. The quadrivalent live attenuated influenza vaccine was not recommended for use during the 2016–2017 season...
Source: Current Opinion in Pediatrics - May 11, 2017 Category: Pediatrics Tags: EMERGENCY AND CRITICAL CARE MEDICINE: Edited by Jean Klig and Clifford W. Bogue Source Type: research

Clinical Care for Severe Acute Respiratory Infection Toolkit: COVID-19 Adaptation
Source: World Health Organization (WHO). Published: 4/9/2020. This 196-page toolkit is intended for clinicians working in intensive care units in low- and middle-income countries, managing adult and pediatric patients with severe forms of acute respiratory infection, including severe pneumonia, acute respiratory distress syndrome, sepsis, and septic shock. It is a hands-on practical guide to be used by healthcare professionals involved in critical care management during the COVID-19 pandemic and outbreaks of influenza (seasonal or avian influenza), Middle East respiratory syndrome coronavirus (MERS-CoV), or other emerging...
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - April 9, 2020 Category: International Medicine & Public Health Source Type: news

Research and Reviews in the Fastlane 120
Welcome to the 120th edition of Research and Reviews in the Fastlane. R&R in the Fastlane is a free resource that harnesses the power of social media to allow some of the best and brightest emergency medicine and critical care clinicians from all over the world tell us what they think is worth reading from the published literature. This edition contains 6 recommended reads. The R&R Editorial Team includes Jeremy Fried, Nudrat Rashid, Soren Rudolph, Anand Swaminathan and, of course, Chris Nickson. Find more R&R in the Fastlane reviews in the R&R Archive, read more about the R&R project or check ou...
Source: Life in the Fast Lane - February 3, 2016 Category: Emergency Medicine Authors: Soren Rudolph Tags: Anaesthetics Clinical Research Education General Surgery Ophthalmology Pediatrics Pharmacology Pre-hospital / Retrieval R&R in the FASTLANE Resuscitation Trauma critical care emergency Emergency Medicine recommendations resea Source Type: blogs

Common Indications for Pediatric Antibiotic Prophylaxis
Antimicrobial prophylaxis prevents infection and/or complications of infection, and is a routine practice for defined procedures in the hospital. Emergency rooms and pediatric acute care facilities do not have automated procedures for antimicrobial prophylaxis in place. The responsibility thus falls on the physician caring for the child to appropriately prescribe antibiotics to prevent infection and complications of infection. Common indications for antimicrobial prophylaxis in the pediatric acute care setting include traumatic wounds, meningococcal exposures, pertussis exposures, and influenza exposures. For each of these...
Source: Emergency Medicine Clinics of North America - July 8, 2013 Category: Emergency Medicine Authors: Matthew B. Laurens Source Type: research

Enterovirus D68 in Critically Ill Children: A Comparison With Pandemic H1N1 Influenza*
Objective: In 2014, the Unites States experienced an outbreak of enterovirus D68 associated with severe respiratory illness. The clinical characteristics associated with severe illness from enterovirus D68 during this outbreak compared with those associated with the 2009 H1N1 influenza virus outbreak are unknown. Design and Setting: In this retrospective cohort study, we characterized the clinical features of children with enterovirus D68 admitted to the PICU between August 1, 2014, and November 1, 2014, and compared them with critically ill children infected with H1N1 influenza during the pandemic admitted between May 1,...
Source: Pediatric Critical Care Medicine - November 1, 2016 Category: Pediatrics Tags: Feature Articles Source Type: research

Mortality and Neurologic Sequelae in Influenza-Associated Encephalopathy: Retrospective Multicenter PICU Cohort in France
CONCLUSIONS: Children requiring PICU admission for influenza-associated encephalopathy/encephalitis have high mortality and morbidity rates. The management remains highly variable due to the lack of guidelines.
Source: Pediatric Critical Care Medicine - November 1, 2021 Category: Pediatrics Tags: Online Brief Reports Source Type: research

Declining influenza vaccination rates in an underserved pediatric primary care center during the COVID-19 pandemic
CONCLUSIONS: Influenza vaccination rates within one pediatric primary care center decreased during the COVID-19 pandemic and have not rebounded, particularly for older children, those identifying as Black, and those without insurance.PMID:36182616 | PMC:PMC9464574 | DOI:10.1016/j.vaccine.2022.09.016
Source: Vaccine - October 1, 2022 Category: Allergy & Immunology Authors: Melissa E Day Melissa Klein Heidi Sucharew Mary Carol Burkhardt Allison Reyner Destiney Giles Andrew F Beck Elizabeth P Schlaudecker Source Type: research

Nucleic Acid-based Testing for Noninfluenza Viral Pathogens in Adults with Suspected Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline
Conclusions: The panel formulated and provided their rationale for recommendations on nucleic acid-based diagnostics for viral pathogens other than influenza for patients with suspected CAP.PMID:33929301 | DOI:10.1164/rccm.202102-0498ST
Source: American Journal of Respiratory and Critical Care Medicine - April 30, 2021 Category: Respiratory Medicine Authors: Scott E Evans Ann L Jennerich Marwan M Azar Bin Cao Kristina Crothers Robert P Dickson Susanne Herold Seema Jain Ann Madhavan Mark L Metersky Laura C Myers Eyal Oren Marcos I Restrepo Makeda Semret Ajay Sheshadri Richard G Wunderink Charles S Dela Cruz Source Type: research